Search Results - "Fierz, Beat"

Applying Peptide and Protein Synthesis to Study Post-translational Modifications in Epigenetics and Beyond by Fierz, Beat

“…Epigenetics research focuses on the study of heritable gene regulatory mechanisms that do not involve changes of the DNA sequence. Such mechanisms include…”
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Biophysics of Chromatin Dynamics by Fierz, Beat, Poirier, Michael G

“…Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate DNA processes, including transcription, replication, and repair…”
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Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells by Cuvier, Olivier, Fierz, Beat

“…Key Points Chromatin is a highly dynamic complex, and chromatin dynamics operate over several orders of magnitude of space and time. Local chromatin dynamics…”
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The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity? by Nagpal, Harsh, Fierz, Beat

“…[Display omitted] •CENP-A and CCAN proteins produce a unique chromatin environment at the centromere.•Flexibility of CENP-A nucleosomes results in more…”
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BAF restricts cGAS on nuclear DNA to prevent innate immune activation by Guey, Baptiste, Wischnewski, Marilena, Decout, Alexiane, Makasheva, Kristina, Kaynak, Murat, Sakar, Mahmut S, Fierz, Beat, Ablasser, Andrea

“…The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate-adenosine…”
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Structural mechanism of cGAS inhibition by the nucleosome by Pathare, Ganesh R., Decout, Alexiane, Glück, Selene, Cavadini, Simone, Makasheva, Kristina, Hovius, Ruud, Kempf, Georg, Weiss, Joscha, Kozicka, Zuzanna, Guey, Baptiste, Melenec, Pauline, Fierz, Beat, Thomä, Nicolas H., Ablasser, Andrea

“…The DNA sensor cyclic GMP–AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer 1 . Upon activation…”
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Chromatin as an expansive canvas for chemical biology by Fierz, Beat, Muir, Tom W

“…Chromatin structure and its modulation by epigenetic mechanisms represent a complex system that regulates gene expression in cells. Chemical biology…”
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Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction by Muir, Tom W, Fierz, Beat, Chatterjee, Champak, McGinty, Robert K, Bar-Dagan, Maya, Raleigh, Daniel P

“…Ubiquitylated histone H2B (uH2B) is a known chromatin modification involved in transcription. Analysis of nucleosome arrays containing chemically synthesized…”
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Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α by Kilic, Sinan, Felekyan, Suren, Doroshenko, Olga, Boichenko, Iuliia, Dimura, Mykola, Vardanyan, Hayk, Bryan, Louise C., Arya, Gaurav, Seidel, Claus A. M., Fierz, Beat

“…The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is poorly understood. Here, we employ multimodal single-molecule Förster…”
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Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor by Mivelaz, Maxime, Cao, Anne-Marinette, Kubik, Slawomir, Zencir, Sevil, Hovius, Ruud, Boichenko, Iuliia, Stachowicz, Anna Maria, Kurat, Christoph F., Shore, David, Fierz, Beat

“…Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating chromatin remodeling and controlling the recruitment of…”
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Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein by Heidarsson, Pétur O., Mercadante, Davide, Sottini, Andrea, Nettels, Daniel, Borgia, Madeleine B., Borgia, Alessandro, Kilic, Sinan, Fierz, Beat, Best, Robert B., Schuler, Benjamin

“…Highly charged intrinsically disordered proteins are essential regulators of chromatin structure and transcriptional activity. Here we identify a surprising…”
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A two-state activation mechanism controls the histone methyltransferase Suv39h1 by Müller, Manuel M, Fierz, Beat, Bittova, Lenka, Liszczak, Glen, Muir, Tom W

“…Suv39h1 is a histone methyltransferase that methylates H3K9 residues in heterochromatic regions of the genome. An approach using semisynthetic chromatin…”
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CENP-A and CENP-B collaborate to create an open centromeric chromatin state by Nagpal, Harsh, Ali-Ahmad, Ahmad, Hirano, Yasuhiro, Cai, Wei, Halic, Mario, Fukagawa, Tatsuo, Sekulić, Nikolina, Fierz, Beat

“…Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated…”
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Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation by Callegari, Andrea, Sieben, Christian, Benke, Alexander, Suter, David M, Fierz, Beat, Mazza, Davide, Manley, Suliana

“…Transcription factors (TFs) regulate gene expression in both prokaryotes and eukaryotes by recognizing and binding to specific DNA promoter sequences. In…”
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SUV39 SET domains mediate crosstalk of heterochromatic histone marks by Stirpe, Alessandro, Guidotti, Nora, Northall, Sarah J, Kilic, Sinan, Hainard, Alexandre, Vadas, Oscar, Fierz, Beat, Schalch, Thomas

“…The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin. How…”
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Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions by Dhall, Abhinav, Wei, Sijie, Fierz, Beat, Woodcock, Christopher L., Lee, Tae-Hee, Chatterjee, Champak

“…The structure of eukaryotic chromatin directly influences gene function, and is regulated by chemical modifications of the core histone proteins. Modification…”
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Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries by Nguyen, Uyen T T, Bittova, Lenka, Müller, Manuel M, Fierz, Beat, David, Yael, Houck-Loomis, Brian, Feng, Vanessa, Dann, Geoffrey P, Muir, Tom W

“…A synthetic library of nucleosomes, each with a DNA-barcode characteristic for a defined post-translational modification (PTM), is used to probe PTM-based…”
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Stability of Nucleosomes Containing Homogenously Ubiquitylated H2A and H2B Prepared Using Semisynthesis by Fierz, Beat, Kilic, Sinan, Hieb, Aaron R, Luger, Karolin, Muir, Tom W

“…Post-translational modifications (PTMs) of histones are an essential feature in the dynamic regulation of chromatin. One of these modifications,…”
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A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage by Kilic, Sinan, Boichenko, Iuliia, Lechner, Carolin C, Fierz, Beat

“…The cellular response to DNA damage results in a signaling cascade that primes chromatin for repair. Combinatorial post-translational modifications (PTMs) play…”
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Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions by Bryan, Louise C, Weilandt, Daniel R, Bachmann, Andreas L, Kilic, Sinan, Lechner, Carolin C, Odermatt, Pascal D, Fantner, Georg E, Georgeon, Sandrine, Hantschel, Oliver, Hatzimanikatis, Vassily, Fierz, Beat

“…Chromatin recruitment of effector proteins involved in gene regulation depends on multivalent interaction with histone post-translational modifications (PTMs)…”
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