Search Results - "Fiers, W"

Mapping gene regulatory networks from single-cell omics data by Fiers, Mark W E J, Minnoye, Liesbeth, Aibar, Sara, Bravo González-Blas, Carmen, Kalender Atak, Zeynep, Aerts, Stein

“…Abstract Single-cell techniques are advancing rapidly and are yielding unprecedented insight into cellular heterogeneity. Mapping the gene regulatory networks…”
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M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection by Eliasson, D G, Omokanye, A, Schön, K, Wenzel, U A, Bernasconi, V, Bemark, M, Kolpe, A, El Bakkouri, K, Ysenbaert, T, Deng, L, Fiers, W, Saelens, X, Lycke, N

“…Matrix protein 2 ectodomain (M2e) is considered an attractive component of a broadly protective, universal influenza A vaccine. Here we challenge the canonical…”
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Identification of Mendel's white flower character by Hellens, Roger P, Moreau, Carol, Lin-Wang, Kui, Schwinn, Kathy E, Thomson, Susan J, Fiers, Mark W.E.J, Frew, Tonya J, Murray, Sarah R, Hofer, Julie M.I, Jacobs, Jeanne M.E, Davies, Kevin M, Allan, Andrew C, Bendahmane, Abdelhafid, Coyne, Clarice J, Timmerman-Vaughan, Gail M, Ellis, T.H. Noel

“…Background: The genetic regulation of flower color has been widely studied, notably as a character used by Mendel and his predecessors in the study of…”
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Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10 by Steidler, Lothar, Hans, Wolfgang, Schotte, Lieven, Neirynck, Sabine, Obermeier, Florian, Falk, Werner, Fiers, Walter, Remaut, Erik

“…The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of inflammatory bowel disease (IBD). Using two mouse models, we show…”
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A “universal” human influenza A vaccine by Fiers, W, De Filette, M, Birkett, A, Neirynck, S, Min Jou, W

“…We have previously reported on a universal human influenza A vaccine, based on the external domain of the transmembrane viral M2-protein (M2e) [Nature Medicine…”
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In plants, highly expressed genes are the least compact by Ren, Xin-Ying, Vorst, Oscar, Fiers, Mark W.E.J., Stiekema, Willem J., Nap, Jan-Peter

“…In both the monocot rice and the dicot Arabidopsis, highly expressed genes have more and longer introns and a larger primary transcript than genes expressed at…”
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Natural and long-lasting cellular immune responses against influenza in the M2e-immune host by Schotsaert, M, Ysenbaert, T, Neyt, K, Ibañez, L I, Bogaert, P, Schepens, B, Lambrecht, B N, Fiers, W, Saelens, X

“…Influenza is a global health concern. Licensed influenza vaccines induce strain-specific virus-neutralizing antibodies but hamper the induction of possibly…”
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Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria by Denecker, G, Vercammen, D, Steemans, M, Vanden Berghe, T, Brouckaert, G, Van Loo, G, Zhivotovsky, B, Fiers, W, Grooten, J, Declercq, W, Vandenabeele, P

“…In L929sAhFas cells, tumor necrosis factor (TNF) leads to necrotic cell death, whereas agonistic anti-Fas antibodies elicit apoptotic cell death. Apoptosis,…”
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Complete Genome Sequence of Lactobacillus plantarum WCFS1 by Kleerebezem, Michiel, Boekhorst, Jos, van Kranenburg, Richard, Molenaar, Douwe, Kuipers, Oscar P., Leer, Rob, Tarchini, Renato, Peters, Sander A., Sandbrink, Hans M., Mark W. E. J. Fiers, Stiekema, Willem, René M. Klein Lankhorst, Bron, Peter A., Hoffer, Sally M., Masja N. Nierop Groot, Kerkhoven, Robert, de Vries, Maaike, Ursing, Björn, de Vos, Willem M., Siezen, Roland J.

“…The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated…”
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The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor by Beyaert, R., Cuenda, A., Vanden Berghe, W., Plaisance, S., Lee, J. C., Haegeman, G., Cohen, P., Fiers, W.

“…Tumour necrosis factor (TNF) is a pleiotropic cytokine, the activities of which include effects on gene expression, cell growth and cell death. The biological…”
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The proteolytic procaspase activation network: an in vitro analysis by Van de Craen, M, Declercq, W, Van den brande, I, Fiers, W, Vandenabeele, P

“…In general, apoptotic stimuli lead to activation of caspases. Once activated, a caspase can induce intracellular signaling pathways involving proteolytic…”
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Direct Evidence for Tumor Necrosis Factor-Induced Mitochondrial Reactive Oxygen Intermediates and Their Involvement in Cytotoxicity by Goossens, Vera, Grooten, Johan, De Vos, Kurt, Fiers, Walter

“…Tumor necrosis factor (TNF) is selectively cytotoxic to some types of tumor cells in vitro and exerts antitumor activity in vivo. Reactive oxygen intermediates…”
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Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene‐inductive effects of TNF by Schulze‐Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., Fiers, W.

“…Tumor necrosis factor (TNF) has cytotoxic and gene‐inductive activities on several cell types. Previous studies on L929 fibrosarcoma cells have revealed that…”
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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role by Vleminckx, K, Vakaet, Jr, L, Mareel, M, Fiers, W, van Roy, F

“…A cDNA encoding the cell-cell adhesion molecule E-cadherin was transfected into highly invasive epithelial tumor cell lines of dog kidney or mouse mammary…”
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Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia by GERARD, C, BRUYNS, C, MARCHANT, A, ABRAMOWICZ, D, VANDENABEELE, P, DELVAUX, A, FIERS, W, GOLDMAN, M, VELU, T

“…Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be of…”
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Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis by Los, Marek, Craen, Marc Van de, Penning, Louis C, Schenk, Heike, Westendorp, Michael, Baeuerle, Patrick A, Dröge, Wulf, Krammer, Peter H, Fiers, Walter, Schulze-Osthoff, Klaus

“…The Fas/APO-1 receptor is one of the major regulators of apoptosis. We report here that Fas/APO-1-mediated apoptosis requires the activation of a new class of…”
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A universal vaccine against influenza by Fiers, W

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Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation by SCHULZE-OSTHOFF, K, BAKKER, A. C, VANHAESEBROECK, B, BEYAERT, R, JACOB, W. A, FIERS, W

“…Structural mitochondrial damage accompanies the cytotoxic effects of several drugs including tumor necrosis factor (TNF). Using various inhibitors of…”
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Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon by Pober, JS, Gimbrone, MA, Jr, Lapierre, LA, Mendrick, DL, Fiers, W, Rothlein, R, Springer, TA

“…We have used the quantitative binding of murine monoclonal antibodies to the surface of cultured human umbilical vein endothelial (HUVE) cells to study the…”
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Post alignment clustering procedure for comparative quantitative proteomics LC-MS Data by de Groot, Joost C. W., Fiers, Mark W. E. J., van Ham, Roeland C. H. J., America, Antoine H. P.

“…Comparative LC‐MS is a powerful method for detailed quantitative comparison of complex protein mixtures. Dedicated software is required for detection,…”
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