Search Results - "Fiers, Mark"

Mapping gene regulatory networks from single-cell omics data by Fiers, Mark W E J, Minnoye, Liesbeth, Aibar, Sara, Bravo González-Blas, Carmen, Kalender Atak, Zeynep, Aerts, Stein

“…Abstract Single-cell techniques are advancing rapidly and are yielding unprecedented insight into cellular heterogeneity. Mapping the gene regulatory networks…”
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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease by Chen, Wei-Ting, Lu, Ashley, Craessaerts, Katleen, Pavie, Benjamin, Sala Frigerio, Carlo, Corthout, Nikky, Qian, Xiaoyan, Laláková, Jana, Kühnemund, Malte, Voytyuk, Iryna, Wolfs, Leen, Mancuso, Renzo, Salta, Evgenia, Balusu, Sriram, Snellinx, An, Munck, Sebastian, Jurek, Aleksandra, Fernandez Navarro, Jose, Saido, Takaomi C., Huitinga, Inge, Lundeberg, Joakim, Fiers, Mark, De Strooper, Bart

“…Although complex inflammatory-like alterations are observed around the amyloid plaques of Alzheimer’s disease (AD), little is known about the molecular changes…”
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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain by Davie, Kristofer, Janssens, Jasper, Koldere, Duygu, De Waegeneer, Maxime, Pech, Uli, Kreft, Łukasz, Aibar, Sara, Makhzami, Samira, Christiaens, Valerie, Bravo González-Blas, Carmen, Poovathingal, Suresh, Hulselmans, Gert, Spanier, Katina I., Moerman, Thomas, Vanspauwen, Bram, Geurs, Sarah, Voet, Thierry, Lammertyn, Jeroen, Thienpont, Bernard, Liu, Sha, Konstantinides, Nikos, Fiers, Mark, Verstreken, Patrik, Aerts, Stein

“…The diversity of cell types and regulatory states in the brain, and how these change during aging, remains largely unknown. We present a single-cell…”
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Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores by Leonenko, Ganna, Baker, Emily, Stevenson-Hoare, Joshua, Sierksma, Annerieke, Fiers, Mark, Williams, Julie, de Strooper, Bart, Escott-Price, Valentina

“…Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little…”
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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology by Sierksma, Annerieke, Lu, Ashley, Mancuso, Renzo, Fattorelli, Nicola, Thrupp, Nicola, Salta, Evgenia, Zoco, Jesus, Blum, David, Buée, Luc, De Strooper, Bart, Fiers, Mark

“…Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease…”
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Melanoma addiction to the long non-coding RNA SAMMSON by Leucci, Eleonora, Vendramin, Roberto, Spinazzi, Marco, Laurette, Patrick, Fiers, Mark, Wouters, Jasper, Radaelli, Enrico, Eyckerman, Sven, Leonelli, Carina, Vanderheyden, Katrien, Rogiers, Aljosja, Hermans, Els, Baatsen, Pieter, Aerts, Stein, Amant, Frederic, Van Aelst, Stefan, van den Oord, Joost, de Strooper, Bart, Davidson, Irwin, Lafontaine, Denis L. J., Gevaert, Kris, Vandesompele, Jo, Mestdagh, Pieter, Marine, Jean-Christophe

“…A known oncogene, MITF , resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA…”
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iRegulon: from a gene list to a gene regulatory network using large motif and track collections by Janky, Rekin's, Verfaillie, Annelien, Imrichová, Hana, Van de Sande, Bram, Standaert, Laura, Christiaens, Valerie, Hulselmans, Gert, Herten, Koen, Naval Sanchez, Marina, Potier, Delphine, Svetlichnyy, Dmitry, Kalender Atak, Zeynep, Fiers, Mark, Marine, Jean-Christophe, Aerts, Stein

“…Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a…”
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Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state by Verfaillie, Annelien, Imrichova, Hana, Atak, Zeynep Kalender, Dewaele, Michael, Rambow, Florian, Hulselmans, Gert, Christiaens, Valerie, Svetlichnyy, Dmitry, Luciani, Flavie, Van den Mooter, Laura, Claerhout, Sofie, Fiers, Mark, Journe, Fabrice, Ghanem, Ghanem-Elias, Herrmann, Carl, Halder, Georg, Marine, Jean-Christophe, Aerts, Stein

“…Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct invasive cell subpopulation is a critical event at the origin of…”
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Identification of Mendel's white flower character by Hellens, Roger P, Moreau, Carol, Lin-Wang, Kui, Schwinn, Kathy E, Thomson, Susan J, Fiers, Mark W.E.J, Frew, Tonya J, Murray, Sarah R, Hofer, Julie M.I, Jacobs, Jeanne M.E, Davies, Kevin M, Allan, Andrew C, Bendahmane, Abdelhafid, Coyne, Clarice J, Timmerman-Vaughan, Gail M, Ellis, T.H. Noel

“…Background: The genetic regulation of flower color has been widely studied, notably as a character used by Mendel and his predecessors in the study of…”
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Biochar induced soil microbial community change: Implications for biogeochemical cycling of carbon, nitrogen and phosphorus by Anderson, Craig R., Condron, Leo M., Clough, Tim J., Fiers, Mark, Stewart, Alison, Hill, Robert A., Sherlock, Robert R.

“…It is generally accepted that biochar-C is largely unavailable to soil microbes but changes in soil physicochemical properties and the introduction of…”
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Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology by Sierksma, Annerieke, Lu, Ashley, Salta, Evgenia, Vanden Eynden, Elke, Callaerts-Vegh, Zsuzsanna, D'Hooge, Rudi, Blum, David, Buée, Luc, Fiers, Mark, De Strooper, Bart

“…Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse models, as well as sporadic AD patients show predictable patterns of episodic…”
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An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody by Batiuk, Mykhailo Y., de Vin, Filip, Duqué, Sandra I., Li, Chen, Saito, Takashi, Saido, Takaomi, Fiers, Mark, Belgard, T. Grant, Holt, Matthew G.

“…Astrocytes are a major cell type in the mammalian CNS. Astrocytes are now known to play a number of essential roles in processes including synapse formation…”
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The draft genome sequence of European pear (Pyrus communis L. 'Bartlett') by Chagné, David, Crowhurst, Ross N, Pindo, Massimo, Thrimawithana, Amali, Deng, Cecilia, Ireland, Hilary, Fiers, Mark, Dzierzon, Helge, Cestaro, Alessandro, Fontana, Paolo, Bianco, Luca, Lu, Ashley, Storey, Roy, Knäbel, Mareike, Saeed, Munazza, Montanari, Sara, Kim, Yoon Kyeong, Nicolini, Daniela, Larger, Simone, Stefani, Erika, Allan, Andrew C, Bowen, Judith, Harvey, Isaac, Johnston, Jason, Malnoy, Mickael, Troggio, Michela, Perchepied, Laure, Sawyer, Greg, Wiedow, Claudia, Won, Kyungho, Viola, Roberto, Hellens, Roger P, Brewer, Lester, Bus, Vincent G M, Schaffer, Robert J, Gardiner, Susan E, Velasco, Riccardo

“…We present a draft assembly of the genome of European pear (Pyrus communis) 'Bartlett'. Our assembly was developed employing second generation sequencing…”
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Structure and expression of GSL1 and GSL2 genes encoding gibberellin stimulated-like proteins in diploid and highly heterozygous tetraploid potato reveals their highly conserved and essential status by Meiyalaghan, Sathiyamoorthy, Thomson, Susan J, Fiers, Mark W E J, Barrell, Philippa J, Latimer, Julie M, Mohan, Sara, Jones, E Eirian, Conner, Anthony J, Jacobs, Jeanne M E

“…GSL1 and GSL2, Gibberellin Stimulated-Like proteins (also known as Snakin-1 and Snakin-2), are cysteine-rich peptides from potato (Solanum tuberosum L.) with…”
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In plants, highly expressed genes are the least compact by Ren, Xin-Ying, Vorst, Oscar, Fiers, Mark W.E.J., Stiekema, Willem J., Nap, Jan-Peter

“…In both the monocot rice and the dicot Arabidopsis, highly expressed genes have more and longer introns and a larger primary transcript than genes expressed at…”
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Genomic analysis of the Kiwifruit pathogen Pseudomonas syringae pv. actinidiae provides insight into the origins of an emergent plant disease by McCann, Honour C, Rikkerink, Erik H A, Bertels, Frederic, Fiers, Mark, Lu, Ashley, Rees-George, Jonathan, Andersen, Mark T, Gleave, Andrew P, Haubold, Bernhard, Wohlers, Mark W, Guttman, David S, Wang, Pauline W, Straub, Christina, Vanneste, Joel L, Vanneste, Joel, Rainey, Paul B, Templeton, Matthew D

“…The origins of crop diseases are linked to domestication of plants. Most crops were domesticated centuries--even millennia--ago, thus limiting opportunity to…”
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Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2 by Claes, Christel, Van Den Daele, Johanna, Boon, Ruben, Schouteden, Sarah, Colombo, Alessio, Monasor, Laura Sebastian, Fiers, Mark, Ordovás, Laura, Nami, FatemehArefeh, Bohrmann, Bernd, Tahirovic, Sabina, De Strooper, Bart, Verfaillie, Catherine M.

“…Murine microglia expressing the Alzheimer's disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is…”
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NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease by Penning, Amber, Snoeck, Sarah, Garritsen, Oxana, Tosoni, Giorgia, Hof, Amber, de Boer, Fleur, van Hasenbroek, Joëlle, Zhang, Lin, Thrupp, Nicky, Craessaerts, Katleen, Fiers, Mark, Salta, Evgenia

“…The generation of new neurons at the hippocampal neurogenic niche, known as adult hippocampal neurogenesis (AHN), and its impairment, have been implicated in…”
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Complete Genome Sequence of Lactobacillus plantarum WCFS1 by Kleerebezem, Michiel, Boekhorst, Jos, van Kranenburg, Richard, Molenaar, Douwe, Kuipers, Oscar P., Leer, Rob, Tarchini, Renato, Peters, Sander A., Sandbrink, Hans M., Mark W. E. J. Fiers, Stiekema, Willem, René M. Klein Lankhorst, Bron, Peter A., Hoffer, Sally M., Masja N. Nierop Groot, Kerkhoven, Robert, de Vries, Maaike, Ursing, Björn, de Vos, Willem M., Siezen, Roland J.

“…The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated…”
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Evolution of Rhizaria: new insights from phylogenomic analysis of uncultivated protists by Burki, Fabien, Kudryavtsev, Alexander, Matz, Mikhail V, Aglyamova, Galina V, Bulman, Simon, Fiers, Mark, Keeling, Patrick J, Pawlowski, Jan

“…Recent phylogenomic analyses have revolutionized our view of eukaryote evolution by revealing unexpected relationships between and within the eukaryotic…”
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