Search Results - "Fierke, Carol A"

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs by Sahoo, Bikash R, Genjo, Takuya, Bekier, Michael, Cox, Sarah J, Stoddard, Andrea K, Ivanova, Magdalena, Yasuhara, Kazuma, Fierke, Carol A, Wang, Yanzhuang, Ramamoorthy, Ayyalusamy

“…Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1-40 aggregation. We demonstrate that…”
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Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing by Howard, Michael J., Lim, Wan Hsin, Fierke, Carol A., Koutmos, Markos

“…Ribonuclease P (RNase P) catalyzes the maturation of the 5' end of tRNA precursors. Typically these enzymes are ribonucleoproteins with a conserved RNA…”
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ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc by Wang, Da, Hosteen, Olijahwon, Fierke, Carol A.

“…In E. coli, ZitB and ZntA are important metal exporters that enhance cell viability under high environmental zinc. To understand their functions in maintaining…”
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Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes by Pithadia, Amit S, Bhunia, Anirban, Sribalan, Rajendran, Padmini, Vediappen, Fierke, Carol A, Ramamoorthy, Ayyalusamy

“…The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual…”
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Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives by Ramamoorthy, Ayyalusamy, Fierke, Carol A., Brender, Jeffrey R., Pithadia, Amit

“…Fibrillar aggregates of human islet amyloid polypeptide, hIAPP, a pathological feature seen in some diabetes patients, are a likely causative agent for…”
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Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA by Teramoto, Takamasa, Kaitany, Kipchumba J, Kakuta, Yoshimitsu, Kimura, Makoto, Fierke, Carol A, Hall, Traci M Tanaka

“…Abstract Pentatricopeptide repeat (PPR) motifs are α-helical structures known for their modular recognition of single-stranded RNA sequences with each motif in…”
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A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors by Yang, Kai S., Ma, Xinyu R., Ma, Yuying, Alugubelli, Yugendar R., Scott, Danielle A., Vatansever, Erol C., Drelich, Aleksandra K., Sankaran, Banumathi, Geng, Zhi Z., Blankenship, Lauren R., Ward, Hannah E., Sheng, Yan J., Hsu, Jason C., Kratch, Kaci C., Zhao, Baoyu, Hayatshahi, Hamed S., Liu, Jin, Li, Pingwei, Fierke, Carol A., Tseng, Chien‐Te K., Xu, Shiqing, Liu, Wenshe Ray

“…The COVID‐19 pathogen, SARS‐CoV‐2, requires its main protease (SC2MPro) to digest two of its translated long polypeptides to form a number of mature proteins…”
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In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy by Patel, Hiren R, Pithadia, Amit S, Brender, Jeffrey R, Fierke, Carol A, Ramamoorthy, Ayyalusamy

“…The deposition of aggregates of human islet amyloid peptide (hIAPP) has been correlated with the death of insulin-producing beta (β) cells in type II diabetes…”
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HDAC8 substrates: Histones and beyond by Wolfson, Noah A., Pitcairn, Carol Ann, Fierke, Carol A.

“…The lysine deacetylase family of enzymes (HDACs) was first demonstrated to catalyze deacetylation of acetyllysine residues on histones. In subsequent years,…”
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Structure-Based Identification of HDAC8 Non-histone Substrates by Alam, Nawsad, Zimmerman, Lior, Wolfson, Noah A., Joseph, Caleb G., Fierke, Carol A., Schueler-Furman, Ora

“…HDAC8 is a member of the family of histone deacetylases (HDACs) that catalyze the deacetylation of acetyl lysine residues within histone and non-histone…”
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Phage‐assisted, active site‐directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor by Morse, Jared S., Sheng, Yan J., Hampton, Joshua Trae, Sylvain, Lauralee D., Das, Sukant, Alugubelli, Yugendar R., Chen, Peng‐Hsun Chase, Yang, Kai S., Xu, Shiqing, Fierke, Carol A., Liu, Wenshe Ray

“…Phage‐assisted, active site‐directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon‐encoded noncanonical amino acid (ncAA)…”
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General Base–General Acid Catalysis in Human Histone Deacetylase 8 by Gantt, Sister M. Lucy, Decroos, Christophe, Lee, Matthew S, Gullett, Laura E, Bowman, Christine M, Christianson, David W, Fierke, Carol A

“…Histone deacetylases (HDACs) regulate cellular processes such as differentiation and apoptosis and are targeted by anticancer therapeutics in development and…”
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Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates by Varga, Julia K., Diffley, Kelsey, Welker Leng, Katherine R., Fierke, Carol A., Schueler-Furman, Ora

“…Histone deacetylases play important biological roles well beyond the deacetylation of histone tails. In particular, HDAC6 is involved in multiple cellular…”
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Ratiometric Zinc Biosensor Based on Bioluminescence Resonance Energy Transfer: Trace Metal Ion Determination with Tunable Response by Matveeva, Evgenia G, Stoddard, Andrea K, Zeng, Hui-Hui, Franke, Graham, Bourne, Leslie, Fierke, Carol A, Thompson, Richard B

“…Determination of metal ions such as zinc in solution remains an important task in analytical and biological chemistry. We describe a novel zinc ion biosensing…”
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Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations by Gantt, Stephanie L., Joseph, Caleb G., Fierke, Carol A.

“…The metal-dependent histone deacetylases (HDACs) catalyze hydrolysis of acetyl groups from acetyllysine side chains and are targets of cancer therapeutics. Two…”
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Ligand Concentration Regulates the Pathways of Coupled Protein Folding and Binding by Daniels, Kyle G, Tonthat, Nam K, McClure, David R, Chang, Yu-Chu, Liu, Xin, Schumacher, Maria A, Fierke, Carol A, Schmidler, Scott C, Oas, Terrence G

“…Coupled ligand binding and conformational change plays a central role in biological regulation. Ligands often regulate protein function by modulating…”
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Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand by Wang, Ningkun, Lodge, Jean M., Fierke, Carol A., Mapp, Anna K.

“…Allosteric binding events play a critical role in the formation and stability of transcriptional activator–coactivator complexes, perhaps in part due to the…”
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Understanding protein palmitoylation： Biological significance and enzymology by Guan, XiaoMu, Fierke, Carol A.

“…Protein palmitoylation is a widespread lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a…”
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Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function by Dowling, Daniel P, Gattis, Samuel G, Fierke, Carol A, Christianson, David W

“…The metal-dependent histone deacetylases (HDACs) adopt an α/β protein fold first identified in rat liver arginase. Despite insignificant overall amino acid…”
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Measuring Picomolar Intracellular Exchangeable Zinc in PC-12 Cells Using a Ratiometric Fluorescence Biosensor by Bozym, Rebecca A, Thompson, Richard B, Stoddard, Andrea K, Fierke, Carol A

“…Zinc plays both physiological and pathological roles in biology, making it of increasing interest. To date, intracellular free zinc has been measured in cell…”
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