Search Results - "Fields, Melanie E"

Editorial: Cerebral oxygen supply and demand in sickle cell disease: Evidence of local ischemia despite global hyperemia by Juttukonda, Meher R, Vaclavu, Lena, Kirkham, Fenella J, Fields, Melanie E, Bush, Adam M

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Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy by Guilliams, Kristin P., MD, MSCI, Fields, Melanie E., MD, MSCI, Ragan, Dustin K., PhD, Chen, Yasheng, DSc, Eldeniz, Cihat, PhD, Hulbert, Monica L., MD, Binkley, Michael M., MSc, Rhodes, James N, Shimony, Joshua S., MD, PhD, McKinstry, Robert C., MD, PhD, Vo, Katie D., MD, An, Hongyu, DSc, Lee, Jin-Moo, MD, PhD, Ford, Andria L., MD, MSCI

“…Abstract Background Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell disease beyond the baseline elevated stroke risk in this…”
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Personalizing transfusion in sickle cell disease: where is the canary in the mine? by Fields, Melanie E.

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With age comes resilience by Wilson, David B., Fields, Melanie E.

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Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease by Guilliams, Kristin P, Fields, Melanie E, Dowling, Michael M

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Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow by Ford, Andria L., Ragan, Dustin K., Fellah, Slim, Binkley, Michael M., Fields, Melanie E., Guilliams, Kristin P., An, Hongyu, Jordan, Lori C., McKinstry, Robert C., Lee, Jin-Moo, DeBaun, Michael R.

“…Silent cerebral infarcts (SCIs) are associated with cognitive impairment in sickle cell anemia (SCA). SCI risk factors include low hemoglobin and elevated…”
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The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease by Ramos, Kristie, Guilliams, Kristin P., Fields, Melanie E.

“…Sickle cell disease (SCD) is complicated by neurologic complications including vasculopathy, hemorrhagic or ischemic overt stroke, silent cerebral infarcts and…”
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Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease by Fields, Melanie E, Guilliams, Kristin P, Ragan, Dustin K, Binkley, Michael M, Eldeniz, Cihat, Chen, Yasheng, Hulbert, Monica L, McKinstry, Robert C, Shimony, Joshua S, Vo, Katie D, Doctor, Allan, An, Hongyu, Ford, Andria L, Lee, Jin-Moo

“…OBJECTIVETo determine mechanisms underlying regional vulnerability to infarction in sickle cell disease (SCD) by measuring voxel-wise cerebral blood flow…”
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Recovery of factor V activity is delayed with reperfusion injury after liver transplant by Thakkar, Mehul, Saini, Surbhi, Stoll, Janis, Kulkarni, Sakil, Wilson, David B., Khan, Adeel, Doyle, Maria, Fields, Melanie E.

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Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia by Fields, Melanie E., Guilliams, Kristin P., Ragan, Dustin, Binkley, Michael M., Mirro, Amy, Fellah, Slim, Hulbert, Monica L., Blinder, Morey, Eldeniz, Cihat, Vo, Katie, Shimony, Joshua S., Chen, Yasheng, McKinstry, Robert C., An, Hongyu, Lee, Jin-Moo, Ford, Andria L.

“…Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell anemia (SCA). We have shown that CTT mitigates signatures of cerebral…”
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Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia by Guilliams, Kristin P., Fields, Melanie E., Ragan, Dustin K., Eldeniz, Cihat, Binkley, Michael M., Chen, Yasheng, Comiskey, Liam S., Doctor, Allan, Hulbert, Monica L., Shimony, Joshua S., Vo, Katie D., McKinstry, Robert C., An, Hongyu, Lee, Jin-Moo, Ford, Andria L.

“…Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia (SCA), but the physiology conferring this benefit is unclear. Cerebral…”
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Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease by Wang, Yan, Fellah, Slim, Reis, Martin, Guilliams, Kristin P., Fields, Melanie E., Steger-May, Karen, Mirro, Amy E., Lewis, Josiah B., Ying, Chunwei, Cohen, Rachel A., Hulbert, Monica L., King, Allison A., Chen, Yasheng, Lee, Jin-Moo, An, Hongyu, Ford, Andria L.

“…Large vessel vasculopathy (LVV), or moyamoya syndrome, increases the risk of stroke in patients with sickle cell disease (SCD), yet effective treatments are…”
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Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls by Fellah, Slim, Ying, Chunwei, Wang, Yan, Guilliams, Kristin P, Fields, Melanie E, Chen, Yasheng, Lewis, Josiah, Mirro, Amy, Cohen, Rachel, Igwe, Nkemdilim, Eldeniz, Cihat, Jiang, Dengrong, Lu, Hanzhang, Powers, William J, Lee, Jin-Moo, Ford, Andria L, An, Hongyu

“…Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic…”
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Cerebral Oxygen Metabolic Stress, Microstructural Injury, and Infarction in Adults With Sickle Cell Disease by Wang, Yan, Fellah, Slim, Fields, Melanie E., Guilliams, Kristin P., Binkley, Michael M., Eldeniz, Cihat, Shimony, Joshua S., Reis, Martin, Vo, Katie D., Chen, Yasheng, Lee, Jin-Moo, An, Hongyu, Ford, Andria L.

“…To determine the patient- and tissue-based relationships between cerebral hemodynamic and oxygen metabolic stress, microstructural injury, and infarct location…”
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Normalization of cerebral hemodynamics after hematopoietic stem cell transplant in children with sickle cell disease by Hulbert, Monica L., Fields, Melanie E., Guilliams, Kristin P., Bijlani, Priyesha, Shenoy, Shalini, Fellah, Slim, Towerman, Alison S., Binkley, Michael M., McKinstry, Robert C., Shimony, Joshua S., Chen, Yasheng, Eldeniz, Cihat, Ragan, Dustin K., Vo, Katie, An, Hongyu, Lee, Jin-Moo, Ford, Andria L.

“…•Children with SCD had normalization of cerebral hemodynamics after stem cell transplant similar to children in the control group.•Stem cell transplant may…”
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Reversibility of Cognitive Deficits and Functional Connectivity With Transfusion in Children With Sickle Cell Disease by Power, Landon C, Mirro, Amy E, Binkley, Micahel M, Wang, Jinli, Guilliams, Kristin P, Lewis, Josiah B, Ford, Andria L, Shimony, Joshua S, An, Hongyu, Lee, Jin-Moo, Fields, Melanie E

“…People with sickle cell disease (SCD) are at risk of cognitive dysfunction independent of stroke. Diminished functional connectivity in select large-scale…”
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Cognitive outcomes of children and adults with sickle cell anaemia: A contemporary cohort by Turner, Ashley D., Power, Landon C., Yan, Yan, Binkley, Michael M., Hood, Anna M., Guilliams, Kristin P., Ford, Andria L., King, Allison A., Fields, Melanie E.

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Higher executive abilities following a blood transfusion in children and young adults with sickle cell disease by Hood, Anna M., King, Allison A., Fields, Melanie E., Ford, Andria L., Guilliams, Kristin P., Hulbert, Monica L., Lee, Jin‐Moo, White, Desiree A.

“…Individuals with sickle cell disease (SCD) experience cognitive deficits; however, it remains unclear whether medical treatments for SCD improve cognition…”
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Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults With and Without Sickle Cell Trait by Wang, Yan, Guilliams, Kristin P., Fields, Melanie E., Fellah, Slim, Binkley, Michael M., Reis, Martin, Vo, Katie D., Chen, Yasheng, Ying, Chunwei, Blinder, Morey, King, Allison A., Hulbert, Monica L., An, Hongyu, Lee, Jin-Moo, Ford, Andria L.

“…Individuals with sickle cell anemia have heightened risk of stroke and cognitive dysfunction. Given its high prevalence globally, whether sickle cell trait…”
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Toward Automated Detection of Silent Cerebral Infarcts in Children and Young Adults With Sickle Cell Anemia by Chen, Yasheng, Wang, Yan, Phuah, Chia-Ling, Fields, Melanie E., Guilliams, Kristin P., Fellah, Slim, Reis, Martin N., Binkley, Michael M., An, Hongyu, Lee, Jin-Moo, McKinstry, Robert C., Jordan, Lori C., DeBaun, Michael R., Ford, Andria L.

“…Silent cerebral infarcts (SCI) in sickle cell anemia (SCA) are associated with future strokes and cognitive impairment, warranting early diagnosis and…”
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