Search Results - "Fields, G B"

Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics by Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., Hubbell, J. A.

“…Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrices: a combination of…”
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Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3) by NAGASE, H, FIELDS, C. G, FIELDS, G. B

“…Members of the matrix metalloproteinase (MMP) family have been implicated in disease states such as arthritis, periodontal disease, and tumor cell invasion and…”
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Chemical synthesis of proteins by Borgia, Jeffrey A, Fields, Gregg B

“…The manipulation of protein structure enables a better understanding of the principles of protein folding, as well as the development of novel therapeutics and…”
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CD44/chondroitin sulfate proteoglycan and alpha 2 beta 1 integrin mediate human melanoma cell migration on type IV collagen and invasion of basement membranes by Knutson, J R, Iida, J, Fields, G B, McCarthy, J B

“…Tumor cell invasion of basement membranes (BM) represents one of the critical steps in the metastatic process. Tumor cell recognition of individual BM matrix…”
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A model for interstitial collagen catabolism by mammalian collagenases by Fields, G B

“…Mammalian collagenases cleave all three alpha chains of native, triple-helical types I, II, and III collagens after the Gly residue of the partial sequence…”
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Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases by Lauer-Fields, Janelle L, Nagase, Hideaki, Fields, Gregg B

“…The matrix metalloproteinase (MMP) family has been implicated in the process of a variety of diseases such as arthritis, atherosclerosis, and tumor cell…”
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Melanoma cell adhesion and spreading activities of a synthetic 124-residue triple-helical "mini-collagen" by FIELDS, C. G, MICKELSON, D. J, DRAKE, S. L, MCCARTHY, J. B, FIELDS, G. B

“…A great variety of cells, such as melanoma cells, fibroblasts, platelets, keratinocytes, and epithelial cells, adhere to and migrate on specific regions within…”
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Promotion of cell adhesion by single-stranded and triple-helical peptide models of basement membrane collagen alpha 1(IV)531-543. Evidence for conformationally dependent and conformationally independent type IV collagen cell adhesion sites by Miles, A J, Skubitz, A P, Furcht, L T, Fields, G B

“…Several regions within the triple-helical domain of type IV collagen function as cellular recognition sites. We have demonstrated previously that melanoma cell…”
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Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site by Fields, G.B., Van Wart, H.E., Birkedal-Hansen, H.

“…The sequence specificity of human skin fibroblast collagenase has been investigated by measuring the rate of hydrolysis of 16 synthetic octapeptides covering…”
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Evaluation of Radiolabeled Type IV Collagen Fragments as Potential Tumor Imaging Agents by Edwards, W. Barry, Anderson, Carolyn J, Fields, Gregg B, Welch, Michael J

“…The objective of this study was to examine radiopharmaceuticals that target the α3β1 integrin to determine if these agents target tumors for diagnostic imaging…”
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A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis by King, D S, Fields, C G, Fields, G B

“…The success of solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl (Fmoc) amino acids is often limited by deleterious side reactions which occur…”
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Promotion of human platelet adhesion and aggregation by a synthetic, triple-helical "mini-collagen" by RAO, G. H. R, FIELDS, C. G, WHITE, J. G, FIELDS, G. B

“…Platelet activation and aggregation by fibrillar collagens are based on substrate primary, secondary, tertiary, and quaternary structure. Although several…”
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Using fluorogenic peptide substrates to assay matrix metalloproteinases by Fields, G B

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Solid-phase synthesis and stability of triple-helical peptides incorporating native collagen sequences by Fields, C G, Lovdahl, C M, Miles, A J, Hagen, V L, Fields, G B

“…A generally applicable solid-phase methodology has been developed for the synthesis of triple-helical polypeptides incorporating native collagen sequences…”
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Mass-spectrometric approaches for DNA-based genetic screening by Fields, G B

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Solid-Phase Peptide Synthesis and Solid-State NMR Spectroscopy of [Ala3-15N][Val1 ]gramicidin A by Fields, Gregg B., Fields, Cynthia G., Petefish, Jonathan, Van Wart, Harold E., Cross, T. A.

“…[Ala3-15N][Val$^{1}$</la tex>]Gramicidin A has been prepared by solid-phase peptide synthesis and studied by solid-state 15N nuclear magnetic resonance…”
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Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides by Nagase, Hideaki, Fields, Gregg B.

“…The matrix metalloproteinase (MMP)/matrixin family has been implicated in both normal tissue remodeling and a variety of diseases associated with abnormal…”
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Melanoma cell CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylation by Lauer-Fields, Janelle L, Malkar, Navdeep B, Richet, Gérard, Drauz, Karlheinz, Fields, Gregg B

“…Invasion of the basement membrane is believed to be a critical step in the metastatic process. Melanoma cells have been shown previously to bind distinct…”
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Backbone and side‐chain dynamics of residues in a partially folded β‐sheet peptide from platelet factor‐4 by Daragan, Vladimir A., Ilyina, Elena E., Fields, Cynthia G., Fields, Gregg B., Mayo, Kevin H.

“…Structurally characterizing partially folded states is problematic given the nature of these transient species. A peptide 20mer, T38AQLIATLKNGRKISLDLQA57…”
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Hydrolysis of Triple-helical Collagen Peptide Models by Matrix Metalloproteinases by Lauer-Fields, Janelle L., Tuzinski, Kathleen A., Shimokawa, Ken-ichi, Nagase, Hideaki, Fields, Gregg B.

“…The matrix metalloproteinase (MMP) family has been implicated in the process of a variety of diseases such as arthritis, atherosclerosis, and tumor cell…”
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