Search Results - "Fields, B."

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma by Fields, Gregg B

“…The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a…”
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Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases by Fields, Gregg B

“…Angiogenesis is facilitated by the proteolytic activities of members of the matrix metalloproteinase (MMP) family. More specifically, MMP-9 and MT1-MMP…”
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Matrix metalloproteinase collagenolysis in health and disease by Amar, Sabrina, Smith, Lyndsay, Fields, Gregg B.

“…The proteolytic processing of collagen (collagenolysis) is critical in development and homeostasis, but also contributes to numerous pathologies. Mammalian…”
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Synthesis and biological applications of collagen-model triple-helical peptides by Fields, Gregg B

“…Triple-helical peptides (THPs) have been utilized as collagen models since the 1960s. The original focus for THP-based research was to unravel the structural…”
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Enantioselective Radical Construction of 5‑Membered Cyclic Sulfonamides by Metalloradical C–H Amination by Hu, Yang, Lang, Kai, Li, Chaoqun, Gill, Joseph B, Kim, Isaac, Lu, Hongjian, Fields, Kimberly B, Marshall, McKenzie, Cheng, Qigan, Cui, Xin, Wojtas, Lukasz, Zhang, X. Peter

“…Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt­(II) complexes of D 2-symmetric chiral amidoporphyrins for…”
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The Expanding Role of MT1-MMP in Cancer Progression by Knapinska, Anna M, Fields, Gregg B

“…For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary…”
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Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site by Sagi, Irit, Havenith, Martina, Grossman, Moran, Born, Benjamin, Heyden, Matthias, Tworowski, Dmitry, Fields, Gregg B

“…Solvent dynamics are an often overlooked component in enzymatic activity. Terahertz spectroscopy, X-ray absorption analysis and molecular dynamics simulations…”
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The history of matrix metalloproteinases: milestones, myths, and misperceptions by Iyer, Rugmani Padmanabhan, Patterson, Nicolle L, Fields, Gregg B, Lindsey, Merry L

“…Since the discovery of tadpole collagenase in 1962, the matrix metalloproteinase (MMP) family has emerged as a significant proteinase group with recognized…”
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AMSSM Position Statement on Cardiovascular Preparticipation Screening in Athletes: Current evidence, knowledge gaps, recommendations and future directions by Drezner, Jonathan A, O'Connor, Francis G, Harmon, Kimberly G, Fields, Karl B, Asplund, Chad A, Asif, Irfan M, Price, David E, Dimeff, Robert J, Bernhardt, David T, Roberts, William O

“…Cardiovascular screening in young athletes is widely recommended and routinely performed prior to participation in competitive sports. While there is general…”
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Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis by Bertini, Ivano, Fragai, Marco, Luchinat, Claudio, Melikian, Maxime, Toccafondi, Mirco, Lauer, Janelle L, Fields, Gregg B

“…The proteolysis of collagen triple-helical structure (collagenolysis) is a poorly understood yet critical physiological process. Presently, matrix…”
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Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage by Li, Qixing, Li, Yanpeng, Liang, Bibo, Xu, Rui, Xu, Bingze, Lönnblom, Erik, Feng, Hui, Bai, Jing'an, Stawikowska, Roma, Ge, Changrong, Lu, Aiping, Fields, Gregg B, Xiao, Lianbo, Holmdahl, Rikard

“…To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a…”
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A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis by Lindsey, Merry L., PhD, Iyer, Rugmani Padmanabhan, PhD, Zamilpa, Rogelio, PhD, Yabluchanskiy, Andriy, MD, PhD, DeLeon-Pennell, Kristine Y., PhD, Hall, Michael E., MD, Kaplan, Abdullah, MD, Zouein, Fouad A., PhD, Bratton, Dustin, BSc, Flynn, Elizabeth R., BSc, Cannon, Presley L., BSc, Tian, Yuan, PhD, Jin, Yu-Fang, PhD, Lange, Richard A., MD, Tokmina-Roszyk, Dorota, MSc, Fields, Gregg B., PhD, de Castro Brás, Lisandra E., PhD

“…Abstract Background Proteolytically released extracellular matrix (ECM) fragments, matricryptins, are biologically active and play important roles in wound…”
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A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils by Xu, Zhongwei, Xu, Bingze, Lundström, Susanna L., Moreno-Giró, Àlex, Zhao, Danxia, Martin, Myriam, Lönnblom, Erik, Li, Qixing, Krämer, Alexander, Ge, Changrong, Cheng, Lei, Liang, Bibo, Tong, Dongmei, Stawikowska, Roma, Blom, Anna M., Fields, Gregg B., Zubarev, Roman A., Holmdahl, Rikard

“…Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We…”
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Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics by Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., Hubbell, J. A.

“…Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrices: a combination of…”
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The Influence of Sport Nutrition Knowledge on Body Composition and Perceptions of Dietary Requirements in Collegiate Athletes by Jagim, Andrew R, Fields, Jennifer B, Magee, Meghan, Kerksick, Chad, Luedke, Joel, Erickson, Jacob, Jones, Margaret T

“…Sport nutrition knowledge has been shown to influence dietary habits of athletes. The purpose of the current study was to examine relationships between sport…”
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HIGH ENERGY POLARIZATION OF BLAZARS: DETECTION PROSPECTS by Chakraborty, N, Pavlidou, V, Fields, B D

“…Emission from blazar jets in the ultraviolet, optical, and infrared is polarized. If these low-energy photons were inverse-Compton scattered, the upscattered…”
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The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer by Oseni, Saheed Oluwasina, Naar, Corey, Pavlović, Mirjana, Asghar, Waseem, Hartmann, James X, Fields, Gregg B, Esiobu, Nwadiuto, Kumi-Diaka, James

“…Chronic inflammation is now recognized as one of the major risk factors and molecular hallmarks of chronic prostatitis, benign prostatic hyperplasia (BPH), and…”
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Body Composition, Energy Availability, Risk of Eating Disorder, and Sport Nutrition Knowledge in Young Athletes by Magee, Meghan K, Jones, Margaret T, Fields, Jennifer B, Kresta, Julie, Khurelbaatar, Chinguun, Dodge, Christopher, Merfeld, Brandon, Ambrosius, Abby, Carpenter, Makenna, Jagim, Andrew R

“…Young athletes may be at risk for low energy availability (LEA) or dietary habits that are indicative of eating disorders. Thus, the purpose of the current…”
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Enzymatic turnover of macromolecules generates long-lasting protein–water-coupled motions beyond reaction steady state by Dielmann-Gessner, Jessica, Grossman, Moran, Nibali, Valeria Conti, Born, Benjamin, Solomonov, Inna, Fields, Gregg B., Havenith, Martina, Sagi, Irit

“…The main focus of enzymology is on the enzyme rates, substrate structures, and reactivity, whereas the role of solvent dynamics in mediating the biological…”
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Differences in Body Fat in Athletes Categorized by Resting Metabolic Rate by Fields, Jennifer B, Askow, Andrew T, Jones, Margaret T, Jagim, Andrew R

“…The purpose of the study was to examine differences in body fat percentage (BF%) across groups stratified by resting metabolic rate (RMR) when normalized to…”
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