Search Results - "Field, Matthew G."

Punctuated evolution of canonical genomic aberrations in uveal melanoma by Field, Matthew G., Durante, Michael A., Anbunathan, Hima, Cai, Louis Z., Decatur, Christina L., Bowcock, Anne M., Kurtenbach, Stefan, Harbour, J. William

“…Cancer is thought to arise through the accumulation of genomic aberrations evolving under Darwinian selection. However, it remains unclear when the aberrations…”
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PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma by Field, Matthew G, Decatur, Christina L, Kurtenbach, Stefan, Gezgin, Gülçin, van der Velden, Pieter A, Jager, Martine J, Kozak, Kaleigh N, Harbour, J William

“…Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter…”
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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
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GNAQ/11 Mutations in Uveal Melanoma: Is YAP the Key to Targeted Therapy? by Field, Matthew G., Harbour, J. William

“…GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and…”
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Correlation of Retinal Nerve Fiber Layer Thickness and Visual Fields in Glaucoma: A Broken Stick Model by Alasil, Tarek, Wang, Kaidi, Yu, Fei, Field, Matthew G, Lee, Hang, Baniasadi, Neda, de Boer, Johannes F, Coleman, Anne L, Chen, Teresa C

“…Purpose To determine the retinal nerve fiber layer (RNFL) thickness at which visual field (VF) damage becomes detectable and associated with structural loss…”
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TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy by Saha, Sanjib, Skeie, Jessica M., Schmidt, Gregory A., Eggleston, Tim, Shevalye, Hanna, Sales, Christopher S., Phruttiwanichakun, Pornpoj, Dusane, Apurva, Field, Matthew G., Rinkoski, Tommy A., Fautsch, Michael P., Baratz, Keith H., Roy, Madhuparna, Jun, Albert S., Pendleton, Chandler, Salem, Aliasger K., Greiner, Mark A.

“…Fuchs endothelial corneal dystrophy (FECD), the leading indication for corneal transplantation in the U.S., causes loss of corneal endothelial cells (CECs) and…”
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Traumatic cataract induced by improper use of a percussion massage gun by Garza Reyes, Arnulfo, Ahmad, Noor-Us-Sabah, Field, Matthew G., Skiles, Sarah, Oetting, Thomas A.

“…We describe a case of traumatic cataract after improper use of a percussion massage gun over the periorbital area. A 38-year-old female with a history of high…”
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Noninvasive Detection of Mitochondrial Dysfunction in Ocular Hypertension and Primary Open-angle Glaucoma by Geyman, Lawrence S, Suwan, Yanin, Garg, Reena, Field, Matthew G, Krawitz, Brian D, Mo, Shelley, Pinhas, Alexander, Ritch, Robert, Rosen, Richard B

“…To assess mitochondrial dysfunction in vivo in ocular hypertension (OHT) and primary open-angle glaucoma (POAG) using retinal metabolic analysis. This was an…”
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Successful response to first-line treatment with osimertinib for choroidal metastasis from EGFR-mutated non-small-cell lung cancer by Field, Matthew G., Boldt, H. Culver, Abu Hejleh, Taher, Binkley, Elaine M.

“…Describe the use of osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, as the first-line treatment in a patient…”
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Retrospective Optimization of the Hawkeye Orbital Fracture Prioritization and Evaluation Algorithms for Triaging Ophthalmic Care by Sanchez, Peter H, Shriver, Erin M, Strampe, Margaret R, Diel, Ryan J, Pham, Chau M, Carter, Keith D, Kemp, Pavlina S, Field, Matthew G

“…Many orbital fracture patients are transferred to tertiary care centers for immediate ophthalmology consultation, though few require urgent ophthalmic…”
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Recent developments in prognostic and predictive testing in uveal melanoma by Field, Matthew G, Harbour, J William

“…PURPOSE OF REVIEWTo provide an update on the rapidly evolving methods for assessing prognosis and predicting response to targeted molecular therapy in uveal…”
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Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes by Decatur, Christina L, Ong, Erin, Garg, Nisha, Anbunathan, Hima, Bowcock, Anne M, Field, Matthew G, Harbour, J William

“…Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic…”
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Noninvasive imaging of mitochondrial dysfunction in dry age-related macular degeneration by Field, Matthew G, Comer, Grant M, Kawaji, Takahiro, Petty, Howard R, Elner, Victor M

“…Oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of age-related macular degeneration (AMD). Because increased flavoprotein…”
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BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas by Field, Matthew G, Kuznetsov, Jeffim N, Bussies, Parker L, Cai, Louie Z, Alawa, Karam A, Decatur, Christina L, Kurtenbach, Stefan, Harbour, J William

“…The strong association between mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in…”
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Posterior Reversible Encephalopathy Syndrome With Visual Disturbances in an Adolescent After Overdose With Adderall XR: A Case Report by Linton, Edward, Pak, Thomas, Halhouli, Oday, Field, Matthew G., Gunderson, Carissa, Chung, Sophia M.

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PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma by Gezgin, Gülçin, Luk, Sietse J, Cao, Jinfeng, Dogrusöz, Mehmet, van der Steen, Dirk M, Hagedoorn, Renate S, Krijgsman, Daniëlle, van der Velden, Pieter A, Field, Matthew G, Luyten, Gregorius P M, Szuhai, Karoly, Harbour, J William, Jordanova, Ekaterina S, Heemskerk, Mirjam H M, Jager, Martine J

“…Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A…”
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Molecular Characteristics of Conjunctival Melanoma Using Whole-Exome Sequencing by Swaminathan, Swarup S, Field, Matthew G, Sant, David, Wang, Gaofeng, Galor, Anat, Dubovy, Sander R, Harbour, J William, Karp, Carol L

“…Conjunctival melanoma (CM) is a highly aggressive ocular cancer for which treatment options are limited; the molecular pathogenesis is poorly understood. To…”
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PRAME induces genomic instability in uveal melanoma by Kurtenbach, Stefan, Sanchez, Margaret I., Kuznetsoff, Jeffim, Rodriguez, Daniel A., Weich, Natalia, Dollar, James J., Cruz, Anthony, Kurtenbach, Sarah, Field, Matthew G., Durante, Michael A., Decatur, Christina, Sorouri, Mahsa, Lai, Fan, Yenisehirli, Gulum, Fang, Bin, Shiekhattar, Ramin, Pelaez, Daniel, Correa, Zelia M., Verdun, Ramiro E., Harbour, J. William

“…PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with…”
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Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas by Field, Matthew G, Durante, Michael A, Decatur, Christina L, Tarlan, Bercin, Oelschlager, Kristen M, Stone, John F, Kuznetsov, Jeffim, Bowcock, Anne M, Kurtenbach, Stefan, Harbour, J William

“…We previously identified PRAME as a biomarker for metastatic risk in Class 1 uveal melanomas. In this study, we sought to define a threshold value for positive…”
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RNA-Sequencing Gene Expression Profiling of Orbital Adipose-Derived Stem Cell Population Implicate HOX Genes and WNT Signaling Dysregulation in the Pathogenesis of Thyroid-Associated Orbitopathy by Tao, Wensi, Ayala-Haedo, Juan A, Field, Matthew G, Pelaez, Daniel, Wester, Sara T

“…The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with…”
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