Search Results - "Field, L Leigh"

Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate by Leslie, Elizabeth J., Carlson, Jenna C., Shaffer, John R., Butali, Azeez, Buxó, Carmen J., Castilla, Eduardo E., Christensen, Kaare, Deleyiannis, Fred W. B., Leigh Field, L., Hecht, Jacqueline T., Moreno, Lina, Orioli, Ieda M., Padilla, Carmencita, Vieira, Alexandre R., Wehby, George L., Feingold, Eleanor, Weinberg, Seth M., Murray, Jeffrey C., Beaty, Terri H., Marazita, Mary L.

“…Nonsyndromic orofacial clefts (OFCs) are a heterogeneous group of common craniofacial birth defects with complex etiologies that include genetic and…”
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Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts by Bureau, Alexandre, Parker, Margaret M, Ruczinski, Ingo, Taub, Margaret A, Marazita, Mary L, Murray, Jeffrey C, Mangold, Elisabeth, Noethen, Markus M, Ludwig, Kirsten U, Hetmanski, Jacqueline B, Bailey-Wilson, Joan E, Cropp, Cheryl D, Li, Qing, Szymczak, Silke, Albacha-Hejazi, Hasan, Alqosayer, Khalid, Field, L Leigh, Wu-Chou, Yah-Huei, Doheny, Kimberly F, Ling, Hua, Scott, Alan F, Beaty, Terri H

“…A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human association and linkage studies, and animal models argue even more…”
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Variation in Antiviral 2′,5′-Oligoadenylate Synthetase (2′5′AS) Enzyme Activity Is Controlled by a Single-Nucleotide Polymorphism at a Splice-Acceptor Site in the OAS1 Gene by Bonnevie-Nielsen, Vagn, Leigh Field, L., Lu, Shao, Zheng, Dong-Jun, Li, Min, Martensen, Pia M., Nielsen, Thomas B., Beck-Nielsen, Henning, Lau, Yu-Lung, Pociot, Flemming

“…It is likely that human genetic differences mediate susceptibility to viral infection and virus-triggered disorders. OAS genes encoding the antiviral enzyme…”
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Association studies of low‐frequency coding variants in nonsyndromic cleft lip with or without cleft palate by Leslie, Elizabeth J., Carlson, Jenna C., Shaffer, John R., Buxó, Carmen J., Castilla, Eduardo E., Christensen, Kaare, Deleyiannis, Frederic W. B., Field, Leigh L., Hecht, Jacqueline T., Moreno, Lina, Orioli, Ieda M., Padilla, Carmencita, Vieira, Alexandre R., Wehby, George L., Feingold, Eleanor, Weinberg, Seth M., Murray, Jeffrey C., Marazita, Mary L.

“…Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a group of common human birth defects with complex etiology. Although genome‐wide association…”
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Interferon Regulatory Factor 6 (IRF6) Gene Variants and the Risk of Isolated Cleft Lip or Palate by Zucchero, Theresa M, Cooper, Margaret E, Maher, Brion S, Daack-Hirsch, Sandra, Nepomuceno, Buena, Ribeiro, Lucilene, Caprau, Diana, Christensen, Kaare, Suzuki, Yasushi, Machida, Junichiro, Natsume, Nagato, Yoshiura, Koh-Ichiro, Vieira, Alexandre R, Orioli, Ieda M, Castilla, Eduardo E, Moreno, Lina, Arcos-Burgos, Mauricio, Lidral, Andrew C, Field, L. Leigh, Liu, You-e, Ray, Ajit, Goldstein, Toby H, Schultz, Rebecca E, Shi, Min, Johnson, Marla K, Kondo, Shinji, Schutte, Brian C, Marazita, Mary L, Murray, Jeffrey C

“…Cleft lip, cleft palate, or the combination of the two is a complex disorder caused by the interaction of several genes and possibly environmental factors. In…”
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Identification of 16q21 as a modifier of nonsyndromic orofacial cleft phenotypes by Carlson, Jenna C., Standley, Jennifer, Petrin, Aline, Shaffer, John R., Butali, Azeez, Buxó, Carmen J., Castilla, Eduardo, Christensen, Kaare, Deleyiannis, Frederic W.‐D., Hecht, Jacqueline T., Field, L. Leigh, Garidkhuu, Ariuntuul, Moreno Uribe, Lina M., Nagato, Natsume, Orioli, Ieda M., Padilla, Carmencita, Poletta, Fernando, Suzuki, Satoshi, Vieira, Alexandre R., Wehby, George L., Weinberg, Seth M., Beaty, Terri H., Feingold, Eleanor, Murray, Jeffrey C., Marazita, Mary L., Leslie, Elizabeth J.

“…ABSTRACT Orofacial clefts (OFCs) are common, complex birth defects with extremely heterogeneous phenotypic presentations. Two common subtypes—cleft lip alone…”
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Induction and activation of antiviral enzyme 2′,5′-oligoadenylate synthetase by in vitro transcribed insulin mRNA and other cellular RNAs by Dan, Meixia, Zheng, Dongjun, Field, L. Leigh, Bonnevie-Nielsen, Vagn

“…Double-stranded RNA (dsRNA) can induce antiviral enzyme 2′,5′-oligoadenylate synthetase (2′5′AS) expression and activate latent 2′5′AS. Our previous data have…”
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OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes by Field, L Leigh, Bonnevie-Nielsen, Vagn, Pociot, Flemming, Lu, Shao, Nielsen, Thomas B, Beck-Nielsen, Henning

“…OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes L. Leigh Field 1 , Vagn Bonnevie-Nielsen 2 ,…”
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The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P by CHOI, Sun J, MARAZITA, Mary L, NARAYANAN, Somnya, ADELA MANSILLA, Maria, GRANJEIRO, José M, VIEIRA, Alexandre R, LIDRAL, Andrew C, MURRAY, Jeffrey C, HART, Thomas C, SUZANNE HART, P, SULIMA, Pawel P, FIELD, L. Leigh, GOLDSTEIN MCHENRY, Toby, GOVIL, Manika, COOPER, Margaret E, LETRA, Ariadne, MENEZES, Renato

“…Human linkage and association studies suggest a gene(s) for nonsyndromic cleft lip with or without cleft palate (CL/P) on chromosome 4q31-q32 at or near the…”
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A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13 by Leslie, Elizabeth J, Carlson, Jenna C, Shaffer, John R, Feingold, Eleanor, Wehby, George, Laurie, Cecelia A, Jain, Deepti, Laurie, Cathy C, Doheny, Kimberly F, McHenry, Toby, Resick, Judith, Sanchez, Carla, Jacobs, Jennifer, Emanuele, Beth, Vieira, Alexandre R, Neiswanger, Katherine, Lidral, Andrew C, Valencia-Ramirez, Luz Consuelo, Lopez-Palacio, Ana Maria, Valencia, Dora Rivera, Arcos-Burgos, Mauricio, Czeizel, Andrew E, Field, L Leigh, Padilla, Carmencita D, Cutiongco-de la Paz, Eva Maria C, Deleyiannis, Frederic, Christensen, Kaare, Munger, Ronald G, Lie, Rolv T, Wilcox, Allen, Romitti, Paul A, Castilla, Eduardo E, Mereb, Juan C, Poletta, Fernando A, Orioli, Iêda M, Carvalho, Flavia M, Hecht, Jacqueline T, Blanton, Susan H, Buxó, Carmen J, Butali, Azeez, Mossey, Peter A, Adeyemo, Wasiu L, James, Olutayo, Braimah, Ramat O, Aregbesola, Babatunde S, Eshete, Mekonen A, Abate, Fikre, Koruyucu, Mine, Seymen, Figen, Ma, Lian, de Salamanca, Javier Enríquez, Weinberg, Seth M, Moreno, Lina, Murray, Jeffrey C, Marazita, Mary L

“…Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth defects in humans,…”
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A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 by Beaty, Terri H, Murray, Jeffrey C, Marazita, Mary L, Munger, Ronald G, Ruczinski, Ingo, Hetmanski, Jacqueline B, Liang, Kung Yee, Wu, Tao, Murray, Tanda, Fallin, M Daniele, Redett, Richard A, Raymond, Gerald, Schwender, Holger, Jin, Sheng-Chih, Cooper, Margaret E, Dunnwald, Martine, Mansilla, Maria A, Leslie, Elizabeth, Bullard, Stephen, Lidral, Andrew C, Moreno, Lina M, Menezes, Renato, Vieira, Alexandre R, Petrin, Aline, Wilcox, Allen J, Lie, Rolv T, Jabs, Ethylin W, Wu-Chou, Yah Huei, Chen, Philip K, Wang, Hong, Ye, Xiaoqian, Huang, Shangzhi, Yeow, Vincent, Chong, Samuel S, Jee, Sun Ha, Shi, Bing, Christensen, Kaare, Melbye, Mads, Doheny, Kimberly F, Pugh, Elizabeth W, Ling, Hua, Castilla, Eduardo E, Czeizel, Andrew E, Ma, Lian, Field, L Leigh, Brody, Lawrence, Pangilinan, Faith, Mills, James L, Molloy, Anne M, Kirke, Peadar N, Scott, John M, Arcos-Burgos, Mauricio, Scott, Alan F

“…Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with…”
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X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate by Kimani, Jane W., Shi, Min, Daack-Hirsch, Sandra, Christensen, Kaare, Moretti-Ferreira, Danilo, Marazita, Mary L., Field, L. Leigh, Canady, John W., Murray, Jeffrey C.

“…Nonsyndromic clefts of the lip and/or palate are common birth defects with a strong genetic component. Based on unequal gender ratios for clefting phenotypes,…”
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Association of low‐frequency genetic variants in regulatory regions with nonsyndromic orofacial clefts by Shaffer, John R., LeClair, Jessica, Carlson, Jenna C., Feingold, Eleanor, Buxó, Carmen J., Christensen, Kaare, Deleyiannis, Frederic W. B., Field, L. Leigh, Hecht, Jacqueline T., Moreno, Lina, Orioli, Ieda M., Padilla, Carmencita, Vieira, Alexandre R., Wehby, George L., Murray, Jeffrey C., Weinberg, Seth M., Marazita, Mary L., Leslie, Elizabeth J.

“…Genome‐wide scans have shown that common risk alleles for orofacial clefts (OFC) tend to be located in noncoding regulatory elements and cumulatively explain…”
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Genome‐wide interaction studies identify sex‐specific risk alleles for nonsyndromic orofacial clefts by Carlson, Jenna C., Nidey, Nichole L., Butali, Azeez, Buxo, Carmen J., Christensen, Kaare, Deleyiannis, Frederic W.‐D., Hecht, Jacqueline T., Field, L. Leigh, Moreno‐Uribe, Lina M., Orioli, Ieda M., Poletta, Fernando A., Padilla, Carmencita, Vieira, Alexandre R., Weinberg, Seth M., Wehby, George L., Feingold, Eleanor, Murray, Jeffrey C., Marazita, Mary L., Leslie, Elizabeth J.

“…Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial birth defect in humans and is notable for its apparent sexual…”
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Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results by Marazita, Mary L, Lidral, Andrew C, Murray, Jeffrey C, Field, L Leigh, Maher, Brion S, Goldstein McHenry, Toby, Cooper, Margaret E, Govil, Manika, Daack-Hirsch, Sandra, Riley, Bridget, Jugessur, Astanand, Felix, Temis, Morene, Lina, Mansilla, M Adela, Vieira, Alexandre R, Doheny, Kim, Pugh, Elizabeth, Valencia-Ramirez, Consuelo, Arcos-Burgos, Mauricio

“…Non-syndromic orofacial clefts, i.e. cleft lip (CL) and cleft palate (CP), are among the most common birth defects. The goal of this study was to identify…”
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Meta-Analysis of 13 Genome Scans Reveals Multiple Cleft Lip/Palate Genes with Novel Loci on 9q21 and 2q32-35 by Marazita, Mary L., Murray, Jeffrey C., Lidral, Andrew C., Arcos-Burgos, Mauricio, Cooper, Margaret E., Goldstein, Toby, Maher, Brion S., Daack-Hirsch, Sandra, Schultz, Rebecca, Mansilla, M. Adela, Field, L. Leigh, Liu, You-e, Prescott, Natalie, Malcolm, Sue, Winter, Robin, Ray, Ajit, Moreno, Lina, Valencia, Consuelo, Neiswanger, Katherine, Wyszynski, Diego F., Bailey-Wilson, Joan E., Albacha-Hejazi, Hasan, Beaty, Terri H., McIntosh, Iain, Hetmanski, Jacqueline B., Tunçbilek, Gökhan, Edwards, Matthew, Harkin, Louise, Scott, Rodney, Roddick, Laurence G.

“…Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex etiology. A 10-cM genome scan of 388 extended…”
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Confirmation of a dyslexia susceptibility locus on chromosome 1p34-p36 in a set of 100 Canadian families by Tzenova, Jordana, Kaplan, Bonnie J., Petryshen, Tracey L., Field, L. Leigh

“…Dyslexia is a common and genetically complex trait that manifests primarily as a reading disability independent of general intelligence and educational…”
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Genome Scan for Loci Involved in Cleft Lip With or Without Cleft Palate, in Chinese Multiplex Families by Marazita, Mary L., Field, L. Leigh, Cooper, Margaret E., Tobias, Rose, Maher, Brion S., Peanchitlertkajorn, Supakit, Liu, You-e

“…Cleft lip with or without cleft palate (CL/P) is a common congenital anomaly. Birth prevalences range from 1/500 to 1/1,000 and are consistently higher in…”
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Localization of a gene for incomplete X-linked congenital stationary night blindness to the interval between DXS6849 and DXS8023 in Xp11.23 by BECH-HANSEN, N. T, BOYCOTT, K. M, GRATTON, K. J, ROSS, D. A, FIELD, L. L, PEARCE, W. G

“…Congenital stationary night blindness (CSNB) is a nonprogressive retinal disorder characterized by night blindness, nystagmus, myopia, a variable decrease in…”
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A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5 by Hsiung, Ging-Yuek R., Kaplan, Bonnie J., Petryshen, Tracey L., Lu, Shao, Field, L. Leigh

“…Dyslexia is a disability in acquiring reading and spelling skills that is independent of general intelligence and educational opportunity, and is highly…”
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