Search Results - "Field, Julie R."

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data by Denny, Joshua C, Bastarache, Lisa, Ritchie, Marylyn D, Carroll, Robert J, Zink, Raquel, Mosley, Jonathan D, Field, Julie R, Pulley, Jill M, Ramirez, Andrea H, Bowton, Erica, Basford, Melissa A, Carrell, David S, Peissig, Peggy L, Kho, Abel N, Pacheco, Jennifer A, Rasmussen, Luke V, Crosslin, David R, Crane, Paul K, Pathak, Jyotishman, Bielinski, Suzette J, Pendergrass, Sarah A, Xu, Hua, Hindorff, Lucia A, Li, Rongling, Manolio, Teri A, Chute, Christopher G, Chisholm, Rex L, Larson, Eric B, Jarvik, Gail P, Brilliant, Murray H, McCarty, Catherine A, Kullo, Iftikhar J, Haines, Jonathan L, Crawford, Dana C, Masys, Daniel R, Roden, Dan M

“…When applied in large scale to electronic medical record data, the PheWAS approach replicates GWAS associations and reveals potentially new pleiotropic…”
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Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of Antidepressants by Henry, L. Keith, Field, Julie R., Adkins, Erika M., Parnas, M. Laura, Vaughan, Roxanne A., Zou, Mu-Fa, Newman, Amy H., Blakely, Randy D.

“…In previous studies examining the structural determinants of antidepressant and substrate recognition by serotonin transporters (SERTs), we identified Tyr-95…”
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Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter by Thompson, Brent J, Jessen, Tammy, Henry, L.K, Field, Julie R, Gamble, Karen L, Gresch, Paul J, Carneiro, Ana M, Horton, Rebecca E, Chisnell, Peter J, Belova, Yekaterina, McMahon, Douglas G, Daws, Lynette C, Blakely, Randy D

“…Serotonin [i.e., 5-hydroxytryptamine (5-HT)]-targeted antidepressants are in wide use for the treatment of mood disorders, although many patients do not show a…”
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Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index by Cronin, Robert M, Field, Julie R, Bradford, Yuki, Shaffer, Christian M, Carroll, Robert J, Mosley, Jonathan D, Bastarache, Lisa, Edwards, Todd L, Hebbring, Scott J, Lin, Simon, Hindorff, Lucia A, Crane, Paul K, Pendergrass, Sarah A, Ritchie, Marylyn D, Crawford, Dana C, Pathak, Jyotishman, Bielinski, Suzette J, Carrell, David S, Crosslin, David R, Ledbetter, David H, Carey, David J, Tromp, Gerard, Williams, Marc S, Larson, Eric B, Jarvik, Gail P, Peissig, Peggy L, Brilliant, Murray H, McCarty, Catherine A, Chute, Christopher G, Kullo, Iftikhar J, Bottinger, Erwin, Chisholm, Rex, Smith, Maureen E, Roden, Dan M, Denny, Joshua C

“…Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as…”
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Targeting glutamate synapses in schizophrenia by Field, Julie R, Walker, Adam G, Conn, P. Jeffrey

“…Although early clinical observations implicated dopamine dysfunction in the neuropathology of schizophrenia, accumulating evidence suggests that multiple…”
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Biobanks and electronic medical records: enabling cost-effective research by Bowton, Erica, Field, Julie R, Wang, Sunny, Schildcrout, Jonathan S, Van Driest, Sara L, Delaney, Jessica T, Cowan, James, Weeke, Peter, Mosley, Jonathan D, Wells, Quinn S, Karnes, Jason H, Shaffer, Christian, Peterson, Josh F, Denny, Joshua C, Roden, Dan M, Pulley, Jill M

“…The use of electronic medical record data linked to biological specimens in health care settings is expected to enable cost-effective and rapid genomic…”
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The IGNITE network: a model for genomic medicine implementation and research by Weitzel, Kristin Wiisanen, Alexander, Madeline, Bernhardt, Barbara A, Calman, Neil, Carey, David J, Cavallari, Larisa H, Field, Julie R, Hauser, Diane, Junkins, Heather A, Levin, Phillip A, Levy, Kenneth, Madden, Ebony B, Manolio, Teri A, Odgis, Jacqueline, Orlando, Lori A, Pyeritz, Reed, Wu, R Ryanne, Shuldiner, Alan R, Bottinger, Erwin P, Denny, Joshua C, Dexter, Paul R, Flockhart, David A, Horowitz, Carol R, Johnson, Julie A, Kimmel, Stephen E, Levy, Mia A, Pollin, Toni I, Ginsburg, Geoffrey S

“…Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by genotyping, sequencing, family…”
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Electronic health record design and implementation for pharmacogenomics: a local perspective by Peterson, Josh F., Bowton, Erica, Field, Julie R., Beller, Marc, Mitchell, Jennifer, Schildcrout, Jonathan, Gregg, William, Johnson, Kevin, Jirjis, Jim N., Roden, Dan M., Pulley, Jill M., Denny, Josh C.

“…The design of electronic health records to translate genomic medicine into clinical care is crucial to successful introduction of new genomic services, yet…”
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Stakeholder engagement: a key component of integrating genomic information into electronic health records by Hartzler, Andrea, McCarty, Catherine A., Rasmussen, Luke V., Williams, Marc S., Brilliant, Murray, Bowton, Erica A., Clayton, Ellen Wright, Faucett, William A., Ferry, Kadija, Field, Julie R., Fullerton, Stephanie M., Horowitz, Carol R., Koenig, Barbara A., McCormick, Jennifer B., Ralston, James D., Sanderson, Saskia C., Smith, Maureen E., Trinidad, Susan Brown

“…Integrating genomic information into clinical care and the electronic health record can facilitate personalized medicine through genetically guided clinical…”
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A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program by Schildcrout, Jonathan S, Shi, Yaping, Danciu, Ioana, Bowton, Erica, Field, Julie R, Pulley, Jill M, Basford, Melissa A, Gregg, William, Cowan, James D, Harrell, Frank E, Roden, Dan M, Peterson, Josh F, Denny, Joshua C

“…Abstract Objectives We describe the development, implementation, and evaluation of a model to pre-emptively select patients for genotyping based on medication…”
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Transmembrane Domain 6 of the Human Serotonin Transporter Contributes to an Aqueously Accessible Binding Pocket for Serotonin and the Psychostimulant 3,4-Methylene Dioxymethamphetamine by Field, Julie R., Henry, L. Keith, Blakely, Randy D.

“…The plasma membrane serotonin (5-HT) transporter (SERT, SLC6A4) clears 5-HT after release at nerve termini and is targeted by both antidepressant medications…”
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Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model by Jones, Carrie K, Engers, Darren W, Thompson, Analisa D, Field, Julie R, Blobaum, Anna L, Lindsley, Stacey R, Zhou, Ya, Gogliotti, Rocco D, Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smith, Yoland, Morrison, Ryan, Daniels, J. Scott, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R

“…There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric…”
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Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7 by Jalan-Sakrikar, Nidhi, Field, Julie R, Klar, Rebecca, Mattmann, Margrith E, Gregory, Karen J, Zamorano, Rocio, Engers, Darren W, Bollinger, Sean R, Weaver, C. David, Days, Emily L, Lewis, L. Michelle, Utley, Thomas J, Hurtado, Miguel, Rigault, Delphine, Acher, Francine, Walker, Adam G, Melancon, Bruce J, Wood, Michael R, Lindsley, Craig W, Conn, P. Jeffrey, Xiang, Zixiu, Hopkins, Corey R, Niswender, Colleen M

“…Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly…”
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Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies by Kaufmann, Kristian W., Dawson, Eric S., Henry, L. Keith, Field, Julie R., Blakely, Randy D., Meiler, Jens

“…To identify potential determinants of substrate selectivity in serotonin (5‐HT) transporters (SERT), models of human and Drosophila serotonin transporters…”
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A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport by Henry, L. Keith, Iwamoto, Hideki, Field, Julie R., Kaufmann, Kristian, Dawson, Eric S., Jacobs, Miriam T., Adams, Chelsea, Felts, Bruce, Zdravkovic, Igor, Armstrong, Vanessa, Combs, Steven, Solis, Ernesto, Rudnick, Gary, Noskov, Sergei Y., DeFelice, Louis J., Meiler, Jens, Blakely, Randy D.

“…Na+- and Cl−-dependent uptake of neurotransmitters via transporters of the SLC6 family, including the human serotonin transporter (SLC6A4), is critical for…”
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Discovery, Synthesis, and Structure−Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats by Engers, Darren W, Field, Julie R, Le, Uyen, Zhou, Ya, Bolinger, Julie D, Zamorano, Rocio, Blobaum, Anna L, Jones, Carrie K, Jadhav, Satyawan, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R

“…Herein we report the discovery, synthesis, and evaluation of a series of N-(4-acetamido)-phenylpicolinamides as positive allosteric modulators of mGlu4…”
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Dopamine signaling architecture in Caenorhabditis elegans by McDonald, Paul W, Jessen, Tammy, Field, Julie R, Blakely, Randy D

“…In this review, we highlight the identification and analysis of molecules orchestrating dopamine (DA) signaling in the nematode Caenorhabditis elegans,…”
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Y95 and E444 Interaction Required for High-Affinity S-Citalopram Binding in the Human Serotonin Transporter by Combs, Steven, Kaufmann, Kristian, Field, Julie R, Blakely, Randy D, Meiler, Jens

“…The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) is responsible for the reuptake of 5-HT following synaptic release, as well as for import…”
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The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems by Luzum, JA, Pakyz, RE, Elsey, AR, Haidar, CE, Peterson, JF, Whirl‐Carrillo, M, Handelman, SK, Palmer, K, Pulley, JM, Beller, M, Schildcrout, JS, Field, JR, Weitzel, KW, Cooper‐DeHoff, RM, Cavallari, LH, O'Donnell, PH, Altman, RB, Pereira, N, Ratain, MJ, Roden, DM, Embi, PJ, Sadee, W, Klein, TE, Johnson, JA, Relling, MV, Wang, L, Weinshilboum, RM, Shuldiner, AR, Freimuth, RR

“…Numerous pharmacogenetic clinical guidelines and recommendations have been published, but barriers have hindered the clinical implementation of…”
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Physician response to implementation of genotype-tailored antiplatelet therapy by Peterson, JF, Field, JR, Unertl, KM, Schildcrout, JS, Johnson, DC, Shi, Y, Danciu, I, Cleator, JH, Pulley, JM, McPherson, JA, Denny, JC, Laposata, M, Roden, DM, Johnson, KB

“…Physician responses to genomic information are vital to the success of precision medicine initiatives. We prospectively studied a pharmacogenomics…”
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