Search Results - "Field, Jared T."

Differential impact of doxorubicin dose on cell death and autophagy pathways during acute cardiotoxicity by Kawalec, Philip, Martens, Matthew D., Field, Jared T., Mughal, Wajihah, Caymo, Andrei Miguel, Chapman, Donald, Xiang, Bo, Ghavami, Saeid, Dolinsky, Vernon W., Gordon, Joseph W.

“…Doxorubicin (DOX) is an effective anthracycline used in chemotherapeutic regimens for a variety of haematological and solid tumors. However, its utility…”
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Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells by Alizadeh, Javad, Zeki, Amir A., Mirzaei, Nima, Tewary, Sandipan, Rezaei Moghadam, Adel, Glogowska, Aleksandra, Nagakannan, Pandian, Eftekharpour, Eftekhar, Wiechec, Emilia, Gordon, Joseph W., Xu, Fred. Y., Field, Jared T., Yoneda, Ken Y., Kenyon, Nicholas J., Hashemi, Mohammad, Hatch, Grant M., Hombach-Klonisch, Sabine, Klonisch, Thomas, Ghavami, Saeid

“…The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP)…”
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Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3 by Martens, Matthew D., Seshadri, Nivedita, Nguyen, Lucas, Chapman, Donald, Henson, Elizabeth S., Xiang, Bo, Falk, Landon, Mendoza, Arielys, Rattan, Sunil, Field, Jared T., Kawalec, Philip, Gibson, Spencer B., Keijzer, Richard, Saleem, Ayesha, Hatch, Grant M., Doucette, Christine A., Karch, Jason M., Dolinsky, Vernon W., Dixon, Ian M., West, Adrian R., Rampitsch, Christof, Gordon, Joseph W.

“…Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent…”
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BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation by da Silva Rosa, Simone C., Martens, Matthew D., Field, Jared T., Nguyen, Lucas, Kereliuk, Stephanie M., Hai, Yan, Chapman, Donald, Diehl-Jones, William, Aliani, Michel, West, Adrian R., Thliveris, James, Ghavami, Saeid, Rampitsch, Christof, Dolinsky, Vernon W., Gordon, Joseph W.

“…Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in muscle…”
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Misoprostol attenuates neonatal cardiomyocyte proliferation through Bnip3, perinuclear calcium signaling, and inhibition of glycolysis by Martens, Matthew D., Field, Jared T., Seshadri, Nivedita, Day, Chelsea, Chapman, Donald, Keijzer, Richard, Doucette, Christine A., Hatch, Grant M., West, Adrian R., Ivanco, Tammy L., Gordon, Joseph W.

“…Systemic hypoxia resulting from preterm birth, altered lung development, and cyanotic congenital heart disease is known to impede the regulatory and…”
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Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress by Field, Jared T., Martens, Matthew D., Mughal, Wajihah, Hai, Yan, Chapman, Donald, Hatch, Grant M., Ivanco, Tammy L., Diehl-Jones, William, Gordon, Joseph W.

“…The cellular response to hypoxia involves the activation of a conserved pathway for gene expression regulated by the transcription factor complex called…”
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Abstract 164: Hypoxia-Induced Cardiomyocyte Mitophagy and Mitochondrial Permeability Transition are Inhibited by Bnip3 Phosphorylation by Martens, Matthew D, Field, Jared T, Mughal, Wajihah, Rampitsch, Christof, Ivanco, Tammy, Diehl-Jones, William, Gordon, Joseph W

“…Abstract only Bnip3 is a hypoxia-inducible initiator of cardiomyocyte cell death and has also been implicated as a mitochondrial receptor for the cellular…”
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Abstract 372: Misoprostol Attenuates Hypoxia-induced Cardiomyocyte Proliferation Through Bnip3 and Perinuclear Calcium Signaling by Martens, Matthew D, Field, Jared T, Seshadri, Nivedita, Day, Chelsea, Doucette, Christine, West, Adrian R, Ivanco, Tammy L, Gordon, Joseph W

“…Abstract only Systemic hypoxia resulting from preterm birth, altered lung development, and cyanotic congenital heart disease is known to impede the regulatory…”
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Misoprostol attenuates hypoxia‐induced neonatal cardiomyocyte proliferation through Bnip3 and perinuclear calcium signaling by Gordon, Joseph W., Martens, Matthew D., Field, Jared T., Chapman, Donald, Day, Chelsea, Keijzer, Richard, West, Adrian R., Ivanco, Tammy L.

“…Abstract only Systemic hypoxia resulting from preterm birth, altered lung development, and cyanotic congenital heart disease is known to impede the regulatory…”
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Nix induced mitochondrial fission and mitophagy inhibits myocyte insulin signaling through mTOR and p70S6 kinase by Gordon, Joseph W., da Silva Rosa, Simone Cristina, Field, Jared T., Martens, Matthew D., West, Adrian R., Aliani, Michel, Dolinsky, Vernon W.

“…Abstract only Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in…”
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108 - Tuning Muscle Energy Homeostasis: The Role of Nix Durig Contractile Activity by Field, Jared T., Martens, Matthew D., Gordon, Joseph W.

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103 - Misoprostol Attenuates Cardiomyocyte Proliferation in the GDM and Hypoxia-Exposed Neonatal Heart by Martens, Matthew D., Field, Jared T., Kereliuk, Stephanie M., Chapman, Donald, Dolinsky, Vernon W., Ivanco, Tammy L., Gordon, Joseph W.

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9 - Therapeutic Targeting of Skeletal Muscle Nix in Early-Onset Insulin Resistance by Rosa, Simone C. Da silva, Martens, MATTHEW D., Field, JARED T., Chapman, Donald, Rampitsch, Christof, Dolinsky, VERNON W., Gordon, JOSEPH W.

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