Search Results - "Field, Helen I"

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker by Takawa, Masashi, Masuda, Ken, Kunizaki, Masaki, Daigo, Yataro, Takagi, Katsunori, Iwai, Yukiko, Cho, Hyun‐Soo, Toyokawa, Gouji, Yamane, Yuka, Maejima, Kazuhiro, Field, Helen I., Kobayashi, Takaaki, Akasu, Takayuki, Sugiyama, Masanori, Tsuchiya, Eijyu, Atomi, Yutaka, Ponder, Bruce A. J., Nakamura, Yusuke, Hamamoto, Ryuji

“…The emphasis in anticancer drug discovery has always been on finding a drug with great antitumor potential but few side‐effects. This can be achieved if the…”
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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers by Hayami, Shinya, Kelly, John D., Cho, Hyun‐Soo, Yoshimatsu, Masanori, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Neal, David E., Yamaue, Hiroki, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…A number of histone demethylases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human disease like…”
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Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers by Yoshimatsu, Masanori, Toyokawa, Gouji, Hayami, Shinya, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Kelly, John D., Neal, David E., Maehara, Yoshihiko, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…Protein arginine methylation is a novel post‐translational modification regulating a diversity of cellular processes, including histone functions, but the…”
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Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression by TAKAWA, Masashi, CHO, Hyun-Soo, DOHMAE, Naoshi, FIELD, Helen I, TSUNODA, Tatsuhiko, KOBAYASHI, Takaaki, AKASU, Takayuki, SUGIYAMA, Masanori, OHNUMA, Shin-Ichi, ATOMI, Yutaka, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAYAMI, Shinya, HAMAMOTO, Ryuji, TOYOKAWA, Gouji, KOGURE, Masaharu, YAMANE, Yuka, IWAI, Yukiko, MAEJIMA, Kazuhiro, UEDA, Koji, MASUDA, Akiko

“…Although the physiologic significance of lysine methylation of histones is well known, whether lysine methylation plays a role in the regulation of nonhistone…”
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Demethylation of RB Regulator MYPT1 by Histone Demethylase LSD1 Promotes Cell Cycle Progression in Cancer Cells by CHO, Hyun-Soo, SUZUKI, Takehiro, FIELD, Helen I, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAMAMOTO, Ryuji, DOHMAE, Naoshi, HAYAMI, Shinya, UNOKI, Motoko, YOSHIMATSU, Masanori, TOYOKAWA, Gouji, TAKAWA, Masashi, TAIPING CHEN, KURASH, Julia K

“…Histone demethylase LSD1 (also known as KDM1 and AOF2) is active in various cancer cells, but its biological significance in human carcinogenesis is…”
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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway by Hayami, Shinya, Yoshimatsu, Masanori, Veerakumarasivam, Abhimanyu, Unoki, Motoko, Iwai, Yukiko, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Yamaue, Hiroki, Ponder, Bruce A J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain…”
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Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B by Cho, Hyun-Soo, Shimazu, Tadahiro, Toyokawa, Gouji, Daigo, Yataro, Maehara, Yoshihiko, Hayami, Shinya, Ito, Akihiro, Masuda, Ken, Ikawa, Noriko, Field, Helen I., Tsuchiya, Eiju, Ohnuma, Shin-ichi, Ponder, Bruce A.J., Yoshida, Minoru, Nakamura, Yusuke, Hamamoto, Ryuji

“…Although heat-shock protein 70 (HSP70), an evolutionarily highly conserved molecular chaperone, is known to be post-translationally modified in various ways…”
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Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer by Toyokawa, Gouji, Masuda, Ken, Daigo, Yataro, Cho, Hyun-Soo, Yoshimatsu, Masanori, Takawa, Masashi, Hayami, Shinya, Maejima, Kazuhiro, Chino, Makoto, Field, Helen I, Neal, David E, Tsuchiya, Eiju, Ponder, Bruce A J, Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This…”
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Enhanced Expression of EHMT2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH1 by Cho, Hyun-Soo, Kelly, John D, Hayami, Shinya, Toyokawa, Gouji, Takawa, Masahi, Yoshimatsu, Masanori, Tsunoda, Tatsuhiko, Field, Helen I, Neal, David E, Ponder, Bruce A.J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Abstract EHMT2 is a histone lysine methyltransferase localized in euchromatin regions and acting as a corepressor for specific transcription factors. Although…”
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Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway by Toyokawa, Gouji, Cho, Hyun-Soo, Masuda, Ken, Yamane, Yuka, Yoshimatsu, Masanori, Hayami, Shinya, Takawa, Masashi, Iwai, Yukiko, Daigo, Yataro, Tsuchiya, Eiju, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Maehara, Yoshihiko, Ponder, Bruce A.J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Abstract A number of histone methyltransferases have been identified and biochemically characterized, but the pathologic roles of their dysfunction in human…”
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The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis by Kang, Daechun, Cho, Hyun-Soo, Toyokawa, Gouji, Kogure, Masaharu, Yamane, Yuka, Iwai, Yukiko, Hayami, Shinya, Tsunoda, Tatsuhiko, Field, Helen I., Matsuda, Koichi, Neal, David E., Ponder, Bruce A. J., Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…Histone lysine methylation plays a fundamental role in chromatin organization. Although a set of histone methyltransferases have been identified and…”
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An automated graphics tool for comparative genomics: the Coulson plot generator by Field, Helen I, Coulson, Richard M R, Field, Mark C

“…Comparative analysis is an essential component to biology. When applied to genomics for example, analysis may require comparisons between the predicted…”
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The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6 by Toyokawa, Gouji, Cho, Hyun-Soo, Iwai, Yukiko, Yoshimatsu, Masanori, Takawa, Masashi, Hayami, Shinya, Maejima, Kazuhiro, Shimizu, Noriaki, Tanaka, Hirotoshi, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Ponder, Bruce A J, Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…Histone methyltransferases and demethylases are known to regulate transcription by altering the epigenetic marks on histones, but the pathologic roles of their…”
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Directly e-mailing authors of newly published papers encourages community curation by Bunt, Stephanie M, Grumbling, Gary B, Field, Helen I, Marygold, Steven J, Brown, Nicholas H, Millburn, Gillian H

“…Much of the data within Model Organism Databases (MODs) comes from manual curation of the primary research literature. Given limited funding and an increasing…”
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Multiple newly identified loci associated with prostate cancer susceptibility by English, Dallas R, Bagnato, Melisa, Christmas, Tim, Severi, Gianluca, Gehr-Swain, Beatrice N, Olama, Ali Amin Al, Ogden, Chris, Parker, Christopher C, Field, Helen I, Easton, Douglas F, Jugurnauth, Sarah K, Brown, Paul M, Dearnaley, David P, Southey, Melissa C, Thompson, Alan, Huddart, Robert A, Horwich, Alan, Neal, David E, Muir, Kenneth R, Hall, Amanda L, Jhavar, Sameer G, Hamdy, Freddie C, Donovan, Jenny L, Tymrakiewicz, Malgorzata, Khoo, Vincent S, Hopper, John L, Bryant, Sarah L, Ardern-Jones, Audrey T, Fisher, Cyril, Kote-Jarai, Zsofia, Giles, Graham G, Jamieson, Charles, Smith, Charmaine, O'Brien, Lynne T, Eeles, Rosalind A, Edwards, Stephen M, Wilkinson, Rosemary A, Cox, Angie, Lewis, Sarah, Cooper, Colin S, Morrison, Jonathan, Guy, Michelle, Lophatananon, Artitaya, Mulholland, Shani, Leongamornlert, Daniel A, Woodhouse, Christopher J

“…Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this…”
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Seq4SNPs: new software for retrieval of multiple, accurately annotated DNA sequences, ready formatted for SNP assay design by Field, Helen I, Scollen, Serena A, Luccarini, Craig, Baynes, Caroline, Morrison, Jonathan, Dunning, Alison M, Easton, Douglas F, Pharoah, Paul D P

“…In moderate-throughput SNP genotyping there was a gap in the workflow, between choosing a set of SNPs and submitting their sequences to proprietary assay…”
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RADARS, a bioinformatics solution that automates proteome mass spectral analysis, optimises protein identification, and archives data in a relational database by Field, Helen I., Fenyö, David, Beavis, Ronald C.

“…RADARS, a rapid, automated, data archiving and retrieval software system for high‐throughput proteomic mass spectral data processing and storage, is described…”
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The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene by Cho, Hyun-Soo, Toyokawa, Gouji, Daigo, Yataro, Hayami, Shinya, Masuda, Ken, Ikawa, Noriko, Yamane, Yuka, Maejima, Kazuhiro, Tsunoda, Tatsuhiko, Field, Helen I., Kelly, John D., Neal, David E., Ponder, Bruce A.J., Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…A number of histone demethylases have been identified and biochemically characterized, yet their biological functions largely remain uncharacterized,…”
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Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway by Pal, Arun, Hall, Belinda S, Nesbeth, Darren N, Field, Helen I, Field, Mark C

“…We demonstrate the presence of a glycosylphosphatidylinositol (GPI) anchor-specific endosomal pathway in the protozoan pathogen Trypanosoma brucei. In higher…”
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Identification of new genetic risk factors for prostate cancer by Guy, Michelle, Kote-Jarai, Zsofia, Giles, Graham G, Al Olama, Ali Amin, Jugurnauth, Sarah K, Mulholland, Shani, Leongamornlert, Daniel A, Edwards, Stephen M, Morrison, Jonathan, Field, Helen I, Southey, Melissa C, Severi, Gianluca, Donovan, Jenny L, Hamdy, Freddie C, Dearnaley, David P, Muir, Kenneth R, Smith, Charmaine, Bagnato, Melisa, Ardern-Jones, Audrey T, Hall, Amanda L, O'Brien, Lynne T, Gehr-Swain, Beatrice N, Wilkinson, Rosemary A, Cox, Angela, Lewis, Sarah, Brown, Paul M, Jhavar, Sameer G, Tymrakiewicz, Malgorzata, Lophatananon, Artitaya, Bryant, Sarah L, Horwich, Alan, Huddart, Robert A, Khoo, Vincent S, Parker, Christopher C, Woodhouse, Christopher J, Thompson, Alan, Christmas, Tim, Ogden, Chris, Fisher, Cyril, Jameson, Charles, Cooper, Colin S, English, Dallas R, Hopper, John L, Neal, David E, Easton, Douglas F, Eeles, Rosalind A

“…There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by…”
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