Search Results - "Fiege, Jessica K"

Genetic ancestry effects on the response to viral infection are pervasive but cell type specific by Randolph, Haley E, Fiege, Jessica K, Thielen, Beth K, Mickelson, Clayton K, Shiratori, Mari, Barroso-Batista, João, Langlois, Ryan A, Barreiro, Luis B

“…Humans differ in their susceptibility to infectious disease, partly owing to variation in the immune response after infection. We used single-cell RNA…”
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Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium by Fiege, Jessica K, Thiede, Joshua M, Nanda, Hezkiel Arya, Matchett, William E, Moore, Patrick J, Montanari, Noe Rico, Thielen, Beth K, Daniel, Jerry, Stanley, Emma, Hunter, Ryan C, Menachery, Vineet D, Shen, Steven S, Bold, Tyler D, Langlois, Ryan A

“…The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the…”
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Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function by Dumm, Rebekah E., Fiege, Jessica K., Waring, Barbara M., Kuo, Chay T., Langlois, Ryan A., Heaton, Nicholas S.

“…Influenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce the eventual death of all infected cells. We and others have shown…”
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Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance by Fiege, Jessica K, Stone, Ian A, Dumm, Rebekah E, Waring, Barbara M, Fife, Brian T, Agudo, Judith, Brown, Brian D, Heaton, Nicholas S, Langlois, Ryan A

“…Influenza A virus (IAV) is a seasonal pathogen with the potential to cause devastating pandemics. IAV infects multiple epithelial cell subsets in the…”
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Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination by Sanders, Autumn E, Arnesen, Henriette, Shepherd, Frances K, Putri, Dira S, Fiege, Jessica K, Pierson, Mark J, Roach, Shanley N, Carlsen, Harald, Masopust, David, Boysen, Preben, Langlois, Ryan A

“…Specific pathogen-free (SPF) laboratory mice dominate preclinical studies for immunology and vaccinology. Unfortunately, SPF mice often fail to accurately…”
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Embracing the heterogeneity of natural viruses in mouse studies by Fiege, Jessica K, Langlois, Ryan A

“…Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many…”
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Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension by Banek, Christopher T, Knuepfer, Mark M, Foss, Jason D, Fiege, Jessica K, Asirvatham-Jeyaraj, Ninitha, Van Helden, Dusty, Shimizu, Yoji, Osborn, John W

“…Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension; however, the therapeutic mechanisms remain unclear. Efferent renal…”
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Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine by Roach, Shanley N, Fiege, Jessica K, Shepherd, Frances K, Wiggen, Talia D, Hunter, Ryan C, Langlois, Ryan A

“…Influenza A viruses (IAV) can cause severe disease and death in humans. IAV infection and the accompanying immune response can result in systemic inflammation,…”
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Investigating influenza A virus infection: tools to track infection and limit tropism by Fiege, Jessica K, Langlois, Ryan A

“…Influenza A viruses display a broad cellular tropism within the respiratory tracts of mammalian hosts. Uncovering the relationship between tropism and virus…”
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Mice with diverse microbial exposure histories as a model for preclinical vaccine testing by Fiege, Jessica K., Block, Katharine E., Pierson, Mark J., Nanda, Hezkiel, Shepherd, Frances K., Mickelson, Clayton K., Stolley, J. Michael, Matchett, William E., Wijeyesinghe, Sathi, Meyerholz, David K., Vezys, Vaiva, Shen, Steven S., Hamilton, Sara E., Masopust, David, Langlois, Ryan A.

“…Laboratory mice comprise an expeditious model for preclinical vaccine testing; however, vaccine immunogenicity in these models often inadequately translates to…”
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MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts by Waring, Barbara M, Sjaastad, Louisa E, Fiege, Jessica K, Fay, Elizabeth J, Reyes, Ismarc, Moriarity, Branden, Langlois, Ryan A

“…Influenza A virus drives significant morbidity and mortality in humans and livestock. Annual circulation of the virus in livestock and waterfowl contributes to…”
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Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway by Roach, Shanley N, Shepherd, Frances K, Mickelson, Clayton K, Fiege, Jessica K, Thielen, Beth K, Pross, Lauren M, Sanders, Autumn E, Mitchell, Jason S, Robertson, Mason, Fife, Brian T, Langlois, Ryan A

“…Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different…”
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The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection by Fiege, Jessica K, Stone, Ian A, Fay, Elizabeth J, Markman, Matthew W, Wijeyesinghe, Sathi, Macchietto, Marissa G, Shen, Steven, Masopust, David, Langlois, Ryan A

“…Resident memory T cells (T ) in the lung are vital for heterologous protection against influenza A virus (IAV). Environmental factors are necessary to…”
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SARS‐CoV‐2 neutralization and serology testing of COVID‐19 convalescent plasma from donors with nonsevere disease by Gniadek, Thomas J., Thiede, Joshua M., Matchett, William E., Gress, Abigail R., Pape, Kathryn A., Fiege, Jessica K., Jenkins, Marc K., Menachery, Vineet D., Langlois, Ryan A., Bold, Tyler D.

“…Background The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID‐19, but donors with a…”
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Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo by Sjaastad, Louisa E., Fay, Elizabeth J., Fiege, Jessica K., Macchietto, Marissa G., Stone, Ian A., Markman, Matthew W., Shen, Steven, Langlois, Ryan A.

“…Influenza virus has a broad cellular tropism in the respiratory tract. Infected epithelial cells sense the infection and initiate an antiviral response. To…”
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Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein by Fiege, Jessica K, Burbach, Brandon J, Shimizu, Yoji

“…The maintenance of T cell repertoire diversity involves the entry of newly developed T cells, as well as the maintenance of memory T cells generated from…”
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Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection by Fiege, Jessica K, Beura, Lalit K, Burbach, Brandon J, Shimizu, Yoji

“…During acute infections, naive Ag-specific CD8 T cells are activated and differentiate into effector T cells, most of which undergo contraction after pathogen…”
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Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice by Asirvatham-Jeyaraj, Ninitha, Fiege, Jessica K, Han, Ruijun, Foss, Jason, Banek, Christopher T, Burbach, Brandon J, Razzoli, Maria, Bartolomucci, Alessandro, Shimizu, Yoji, Panoskaltsis-Mortari, Angela, Osborn, John W

“…Hypertension often occurs in concurrence with obesity and diabetes mellitus, commonly referred to as metabolic syndrome. Renal denervation (RDNx) lowers…”
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Indelible labeling and tracking of influenza virus infected antigen presenting cells by Langlois, Ryan A, Fiege, Jessica K

“…Abstract Influenza A virus is a seasonal pathogen with the potential to unpredictably cause catastrophic pandemics. The virus primarily replicates in…”
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Evaluating Influenza A virus vaccines in a dirty mouse model better mimics the human immune response by Fiege, Jessica K, Block, Katharine E, Pierson, Mark J, Pape, Kathryn A, Jenkins, Marc K, Hamilton, Sara E, Masopust, David, Langlois, Ryan A

“…Abstract Current seasonal influenza A virus (IAV) vaccines often exhibit reduced efficacy to seasonal strains and offer limited protection to novel pandemics…”
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