Search Results - "Fiedler, Lorna R."

The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis by Fiedler, Lorna R, Wojciak-Stothard, Beata

“…ADMA (asymmetric dimethylarginine) is a cardiovascular risk factor and an endogenous inhibitor of NOS (nitric oxide synthase). ADMA is metabolized by DDAHs…”
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The ADMA/DDAH Pathway Regulates VEGF-Mediated Angiogenesis by Fiedler, Lorna R, Bachetti, Tiziana, Leiper, James, Zachary, Ian, Chen, Lihua, Renné, Thomas, Wojciak-Stothard, Beata

“…OBJECTIVES—Asymmetrical dimethylarginine (ADMA) is a nitric oxide synthase (NOS) inhibitor and cardiovascular risk factor associated with angiogenic disorders…”
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Rac1 regulates cardiovascular development and postnatal function of endothelium by Fiedler, Lorna R.

“…Rac1 is a member of the small Rho GTPase family, which controls actin cytoskeleton and focal adhesion dynamics in cellular protrusions. While Rac1 therefore…”
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Titin-truncating variants affect heart function in disease cohorts and the general population by Schafer, Sebastian, de Marvao, Antonio, Adami, Eleonora, Fiedler, Lorna R, Ng, Benjamin, Khin, Ester, Rackham, Owen J L, van Heesch, Sebastiaan, Pua, Chee J, Kui, Miao, Walsh, Roddy, Tayal, Upasana, Prasad, Sanjay K, Dawes, Timothy J W, Ko, Nicole S J, Sim, David, Chan, Laura L H, Chin, Calvin W L, Mazzarotto, Francesco, Barton, Paul J, Kreuchwig, Franziska, de Kleijn, Dominique P V, Totman, Teresa, Biffi, Carlo, Tee, Nicole, Rueckert, Daniel, Schneider, Valentin, Faber, Allison, Regitz-Zagrosek, Vera, Seidman, Jonathan G, Seidman, Christine E, Linke, Wolfgang A, Kovalik, Jean-Paul, O'Regan, Declan, Ware, James S, Hubner, Norbert, Cook, Stuart A

“…Stuart Cook and colleagues study the role of TTN (titin)-truncating variants using a combination of heart physiology experiments in rats and genomic analysis…”
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Decorin regulates endothelial cell-matrix interactions during angiogenesis by Fiedler, Lorna R., Eble, Johannes A.

“…Interactions between endothelial cells and the surrounding extracellular matrix are continuously adapted during angiogenesis, from early sprouting through to…”
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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo by Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

“…Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no…”
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Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo by Zhou, Jin, Ng, Benjamin, Ko, Nicole S J, Fiedler, Lorna R, Khin, Ester, Lim, Andrea, Sahib, Norliza E, Wu, Yajun, Chothani, Sonia P, Schafer, Sebastian, Bay, Boon-Huat, Sinha, Rohit A, Cook, Stuart A, Yen, Paul M

“…Titin-truncating variants (TTNtv) are the most common genetic cause of dilated cardiomyopathy. TTNtv occur in ~1% of the general population and causes…”
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Decorin Regulates Endothelial Cell Motility on Collagen I through Activation of Insulin-like Growth Factor I Receptor and Modulation of α2β1 Integrin Activity by Fiedler, Lorna R., Schönherr, Elke, Waddington, Rachel, Niland, Stephan, Seidler, Daniela G., Aeschlimann, Daniel, Eble, Johannes A.

“…The proteoglycan decorin is expressed by sprouting but not quiescent endothelial cells, and angiogenesis is dysregulated in its absence. Previously, we have…”
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Mouse models of heart failure: cell signaling and cell survival by Fiedler, Lorna R, Maifoshie, Evie, Schneider, Michael D

“…Heart failure is one of the paramount global causes of morbidity and mortality. Despite this pandemic need, the available clinical counter-measures have not…”
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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo by Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

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T₁ mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy by Stuckey, Daniel J, McSweeney, Sara J, Thin, May Zaw, Habib, Josef, Price, Anthony N, Fiedler, Lorna R, Gsell, Willy, Prasad, Sanjay K, Schneider, Michael D

“…Diffuse interstitial fibrosis is present in diverse cardiomyopathies and associated with poor prognosis. We investigated whether magnetic resonance…”
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T 1 Mapping Detects Pharmacological Retardation of Diffuse Cardiac Fibrosis in Mouse Pressure-Overload Hypertrophy by Stuckey, Daniel J., McSweeney, Sara J., Thin, May Zaw, Habib, Josef, Price, Anthony N., Fiedler, Lorna R., Gsell, Willy, Prasad, Sanjay K., Schneider, Michael D.

“…Background— Diffuse interstitial fibrosis is present in diverse cardiomyopathies and associated with poor prognosis. We investigated whether magnetic resonance…”
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Decorin Regulates Endothelial Cell Motility on Collagen I through Activation of Insulin-like Growth Factor I Receptor and Modulation of α2β1 Integrin Activity by Lorna R. Fiedler, Elke Schönherr, Rachel Waddington, Stephan Niland, Daniela G. Seidler, Daniel Aeschlimann, Johannes A. Eble

“…The proteoglycan decorin is expressed by sprouting but not quiescent endothelial cells, and angiogenesis is dysregulated in its absence. Previously, we have…”
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Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity by Fiedler, Lorna R, Schönherr, Elke, Waddington, Rachel, Niland, Stephan, Seidler, Daniela G, Aeschlimann, Daniel, Eble, Johannes A

“…The proteoglycan decorin is expressed by sprouting but not quiescent endothelial cells, and angiogenesis is dysregulated in its absence. Previously, we have…”
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Mouse Models of Heart Failure by Fiedler, Lorna R., Maifoshie, Evie, Schneider, Michael D.

“…Heart failure is one of the paramount global causes of morbidity and mortality. Despite this pandemic need, the available clinical counter-measures have not…”
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