Search Results - "Fidock, DA"

Antimalarial drug discovery: efficacy models for compound screening by Fidock, David A, Rosenthal, Philip J, Croft, Simon L, Brun, Reto, Nwaka, Solomon

“…Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to develop safe and affordable new drugs to counter the spread of…”
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum by Gulati, Sonia, Ekland, Eric H., Ruggles, Kelly V., Chan, Robin B., Jayabalasingham, Bamini, Zhou, Bowen, Mantel, Pierre-Yves, Lee, Marcus C.S., Spottiswoode, Natasha, Coburn-Flynn, Olivia, Hjelmqvist, Daisy, Worgall, Tilla S., Marti, Matthias, Di Paolo, Gilbert, Fidock, David A.

“…During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids. Consistent…”
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pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum by Sidhu, Amar Bir Singh, Valderramos, Stephanie Gaw, Fidock, David A.

“…Summary The emergence and spread of multidrug resistant Plasmodium falciparum has severely limited the therapeutic options for the treatment of malaria. With…”
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Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin by Sidhu, Amar Bir Singh, Uhlemann, Anne-Catrin, Valderramos, Stephanie G., Valderramos, Juan-Carlos, Krishna, Sanjeev, Fidock, David A.

“…The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)–based combination therapies for…”
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Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations by Amar Bir Singh Sidhu, Verdier-Pinard, Dominik, Fidock, David A.

“…Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies…”
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In Vivo Selection of Plasmodium falciparum Parasites Carrying the Chloroquine-Susceptible pfcrt K76 Allele after Treatment with Artemether-Lumefantrine in Africa by Sisowath, Christin, Petersen, Ines, Veiga, M. Isabel, Mårtensson, Andreas, Premji, Zul, Björkman, Anders, Fidock, David A., Gil, José P.

“…BackgroundArtemether-lumefantrine (AL) is a major and highly effective artemisinin-based combination therapy that is becoming increasingly important as a new…”
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Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport by Calçada, Carla, Silva, Miguel, Baptista, Vitória, Thathy, Vandana, Silva-Pedrosa, Rita, Granja, Diana, Ferreira, Pedro Eduardo, Gil, José Pedro, Fidock, David A, Veiga, Maria Isabel

“…Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by…”
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Recent highlights in antimalarial drug resistance and chemotherapy research by Fidock, David A, Eastman, Richard T, Ward, Stephen A, Meshnick, Steven R

“…This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and…”
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Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance by Fidock, David A., Nomura, Takashi, Talley, Angela K., Cooper, Roland A., Dzekunov, Sergey M., Ferdig, Michael T., Ursos, Lyann M.B., bir Singh Sidhu, Amar, Naudé, Bronwen, Deitsch, Kirk W., Su, Xin-zhuan, Wootton, John C., Roepe, Paul D., Wellems, Thomas E.

“…The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This…”
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Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance by Bray, Patrick G., Martin, Rowena E., Tilley, Leann, Ward, Stephen A., Kirk, Kiaran, Fidock, David A.

“…Summary Recent studies have highlighted the importance of a parasite protein referred to as the chloroquine resistance transporter (PfCRT) in the molecular…”
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A Molecular Marker for Chloroquine-Resistant Falciparum Malaria by Djimdé, Abdoulaye, Doumbo, Ogobara K, Doumbo, Safi, Cortese, Joseph F, Kayentao, Kassoum, Diourté, Yacouba, Coulibaly, Drissa, Dicko, Alassane, Su, Xin-zhuan, Nomura, Takashi, Fidock, David A, Wellems, Thomas E, Plowe, Christopher V

“…Falciparum malaria remains a major cause of disease and death among children and pregnant women in sub-Saharan Africa. During the second half of the 20th…”
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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance by Lakshmanan, Viswanathan, Bray, Patrick G, Verdier-Pinard, Dominik, Johnson, David J, Horrocks, Paul, Muhle, Rebecca A, Alakpa, George E, Hughes, Ruth H, Ward, Steve A, Krogstad, Donald J, Sidhu, Amar Bir Singh, Fidock, David A

“…Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT. However, the…”
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Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents by Johnson, David J., Fidock, David A., Mungthin, Mathirut, Lakshmanan, Viswanathan, Sidhu, Amar Bir Singh, Bray, Patrick G., Ward, Stephen A.

“…Chloroquine resistance in Plasmodium falciparum is primarily conferred by mutations in pfcrt. Parasites resistant to chloroquine can display hypersensitivity…”
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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data by Kuo, Mack R, Morbidoni, Hector R, Alland, David, Sneddon, Scott F, Gourlie, Brian B, Staveski, Mark M, Leonard, Marina, Gregory, Jill S, Janjigian, Andrew D, Yee, Christopher, Musser, James M, Kreiswirth, Barry, Iwamoto, Hiroyuki, Perozzo, Remo, Jacobs, Jr, William R, Sacchettini, James C, Fidock, David A

“…Tuberculosis and malaria together result in an estimated 5 million deaths annually. The spread of multidrug resistance in the most pathogenic causative agents,…”
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Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase by Kuo, Mack R., Morbidoni, Hector R., Alland, David, Sneddon, Scott F., Gourlie, Brian B., Staveski, Mark M., Leonard, Marina, Gregory, Jill S., Janjigian, Andrew D., Yee, Christopher, Musser, James M., Kreiswirth, Barry, Iwamoto, Hiroyuki, Perozzo, Remo, Jacobs, William R., Sacchettini, James C., Fidock, David A.

“…Tuberculosis and malaria together result in an estimated 5 million deaths annually. The spread of multidrug resistance in the most pathogenic causative agents,…”
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Transformation with Human Dihydrofolate Reductase Renders Malaria Parasites Insensitive to WR99210 but does not Affect the Intrinsic Activity of Proguanil by Fidock, David A., Wellems, Thomas E.

“…Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors pyrimethamine and cycloguanil…”
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Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase by Perozzo, Remo, Kuo, Mack, Sidhu, Amar bir Singh, Valiyaveettil, Jacob T., Bittman, Robert, Jacobs, William R., Fidock, David A., Sacchettini, James C.

“…The human malaria parasite Plasmodium falciparum synthesizes fatty acids using a type II pathway that is absent in humans. The final step in fatty acid…”
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Evidence for a pfcrt-Associated Chloroquine Efflux System in the Human Malarial Parasite Plasmodium falciparum by Sanchez, Cecilia P, McLean, Jeremy E, Rohrbach, Petra, Fidock, David A, Stein, Wilfred D, Lanzer, Michael

“…Resistance to the antimalarial drug chloroquine has been linked with polymorphisms within a gene termed pfcrt in the human malarial parasite Plasmodium…”
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Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum by Cooper, Roland A, Ferdig, Michael T, Su, Xin-Zhuan, Ursos, Lyann M B, Mu, Jianbing, Nomura, Takashi, Fujioka, Hisashi, Fidock, David A, Roepe, Paul D, Wellems, Thomas E

“…Chloroquine resistance (CQR) in Plasmodium falciparum is associated with multiple mutations in the digestive vacuole membrane protein PfCRT. The…”
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Genetic Disruption of the Plasmodium falciparum Digestive Vacuole Plasmepsins Demonstrates Their Functional Redundancy by Omara-Opyene, A. Levi, Moura, Pedro A., Sulsona, Carlos R., Bonilla, J. Alfredo, Yowell, Charles A., Fujioka, Hisashi, Fidock, David A., Dame, John B.

“…The digestive vacuole plasmepsins PfPM1, PfPM2, PfPM4, and PfHAP (a histoaspartic proteinase) are 4 aspartic proteinases among 10 encoded in the Plasmodium…”
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