Search Results - "Fidler, Trevor P."

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein by Yalcinkaya, Mustafa, Liu, Wenli, Islam, Mohammad N., Kotini, Andriana G., Gusarova, Galina A., Fidler, Trevor P., Papapetrou, Eirini P., Bhattacharya, Jahar, Wang, Nan, Tall, Alan R.

“…Despite the initial success of some drugs and vaccines targeting COVID-19, understanding the mechanism underlying SARS-CoV-2 disease pathogenesis remains…”
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Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis by Liu, Wenli, Östberg, Nataliya K, Yalcinkaya, Mustafa, Dou, Huijuan, Endo-Umeda, Kaori, Tang, Yang, Hou, Xintong, Xiao, Tong, Filder, Trevor, Abramowicz, Sandra, Yang, Yong-Guang, Soehnlein, Oliver, Tall, Alan R, Wang, Nan

“…Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases…”
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Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function by Fidler, Trevor P., Campbell, Robert A., Funari, Trevor, Dunne, Nicholas, Balderas Angeles, Enrique, Middleton, Elizabeth A., Chaudhuri, Dipayan, Weyrich, Andrew S., Abel, E. Dale

“…Anucleate platelets circulate in the blood to facilitate thrombosis and diverse immune functions. Platelet activation leading to clot formation correlates with…”
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Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes by Moore, Chad D, Roberts, Jessica K, Orton, Christopher R, Murai, Takahiro, Fidler, Trevor P, Reilly, Christopher A, Ward, Robert M, Yost, Garold S

“…Asthma is one of the most prevalent diseases in the world, for which the mainstay treatment has been inhaled glucocorticoids (GCs). Despite the widespread use…”
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Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function by Fidler, Trevor P., Campbell, Robert A., Funari, Trevor, Dunne, Nicholas, Balderas Angeles, Enrique, Middleton, Elizabeth A., Chaudhuri, Dipayan, Weyrich, Andrew S., Abel, E. Dale

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Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function by Fidler, Trevor P., Campbell, Robert A., Funari, Trevor, Dunne, Nicholas, Balderas Angeles, Enrique, Middleton, Elizabeth A., Chaudhuri, Dipayan, Weyrch, Andrew S., Abel, E. Dale

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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis by Fidler, Trevor P., Xue, Chenyi, Yalcinkaya, Mustafa, Hardaway, Brian, Abramowicz, Sandra, Xiao, Tong, Liu, Wenli, Thomas, David G., Hajebrahimi, Mohammad Ali, Pircher, Joachim, Silvestre-Roig, Carlos, Kotini, Andriana G., Luchsinger, Larry L., Wei, Ying, Westerterp, Marit, Snoeck, Hans-Willem, Papapetrou, Eirini P., Schulz, Christian, Massberg, Steffen, Soehnlein, Oliver, Ebert, Benjamin, Levine, Ross L., Reilly, Muredach P., Libby, Peter, Wang, Nan, Tall, Alan R.

“…Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic…”
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Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis by Hsu, Cheng-Chieh, Fidler, Trevor P, Kanter, Jenny E, Kothari, Vishal, Kramer, Farah, Tang, Jingjing, Tall, Alan R, Bornfeldt, Karin E

“…Serum apolipoprotein C3 (APOC3) predicts incident cardiovascular events in people with type 1 diabetes, and silencing of APOC3 prevents both lesion initiation…”
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Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging by Sonkar, Vijay K., Eustes, Alicia S., Ahmed, Azaj, Jensen, Melissa, Solanki, Mitali V., Swamy, Jagadish, Kumar, Rahul, Fidler, Trevor P., Houtman, Jon C.D., Allen, Bryan G., Spitz, Douglas R., Abel, E. Dale, Dayal, Sanjana

“…Reactive oxygen species (ROS) contribute to platelet hyperactivation during aging. Several oxidative pathways and antioxidant enzymes have been implicated;…”
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Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes by Fidler, Trevor P, Marti, Alex, Gerth, Katelyn, Middleton, Elizabeth A, Campbell, Robert A, Rondina, Matthew T, Weyrich, Andrew S, Abel, E Dale

“…Patients with type 1 diabetes mellitus (T1DM) have increased thrombosis and platelet activation. The mechanisms for platelet hyperactivation in diabetes are…”
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Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk by Yu, Zhi, Fidler, Trevor P, Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J Brett, Zekavat, Seyedeh M, Gibson, Christopher J, Griffin, Gabriel K, Wang, Yuxuan, Peloso, Gina M, Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S, Aguet, François, Ardlie, Kristin G, Taylor, Kent D, Rich, Stephen S, Rotter, Jerome I, Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L, Bick, Alexander G, Tall, Alan R, Natarajan, Pradeep

“…Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome…”
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An epigenetic switch in macrophages promotes fibrosis in the failing heart by Tall, Alan R, Fidler, Trevor P

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Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation by Fidler, Trevor P, Middleton, Elizabeth A, Rowley, Jesse W, Boudreau, Luc H, Campbell, Robert A, Souvenir, Rhonda, Funari, Trevor, Tessandier, Nicolas, Boilard, Eric, Weyrich, Andrew S, Abel, E Dale

“…OBJECTIVE—On activation, platelets increase glucose uptake, glycolysis, and glucose oxidation and consume stored glycogen. This correlation between glucose…”
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Improved Coiled-Coil Design Enhances Interaction with Bcr-Abl and Induces Apoptosis by Dixon, Andrew S, Miller, Geoffrey D, Bruno, Benjamin J, Constance, Jonathan E, Woessner, David W, Fidler, Trevor P, Robertson, James C, Cheatham, Thomas E, Lim, Carol S

“…The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML). , The…”
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Correction to “Improved Coiled-Coil Design Enhances Interaction with Bcr-Abl and Induces Apoptosis” by Dixon, Andrew S, Miller, Geoffrey D, Bruno, Benjamin J, Constance, Jonathan E, Woessner, David W, Fidler, Trevor P, Robertson, James C, Cheatham, Thomas E, Lim, Carol S

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Abstract 108: Il-1β Inhibition Promotes Fibrous Cap Thickening and Accumulation of Fibroblast Like Cells in Atheromas in Clonal Hematopoiesis by Fidler, Trevor P, Kim, Eunyoung, Hardaway, Brian, Xue, Chenyi, Abramowicz, Sandra, Xiao, Tong, Maegdefessel, Lars, Wang, Nan, Tall, Alan

“…Abstract only Clonal hematopoiesis (CH), a highly prevalent condition in the elderly, arises from somatic mutations that endow a survival advantage to…”
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Abstract 143: Il-1β Antagonism Promotes SMC Differentiation And Accumulation In Fibrous Caps In Jak2 V617f Clonal Hematopoiesis by Fidler, Trevor P, Kim, Eunyoung, Xue, Chenyi, Hardaway, Brian, Abramowicz, Sandra, Wang, Nan, Reilly, Muredach P, Tall, Alan

“…Abstract only Patients with JAK2 V617F (JAK2 VF ) clonal hematopoiesis (CH) have increased JAK/STATsignaling that imparts an increased risk of premature…”
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Abstract 143: Il-1β Antagonism Promotes SMC Differentiation And Accumulation In Fibrous Caps In Jak2V617f Clonal Hematopoiesis by Fidler, Trevor P, Kim, Eunyoung, Xue, Chenyi, Hardaway, Brian, Abramowicz, Sandra, Wang, Nan, Reilly, Muredach P, Tall, Alan

“…Patients with JAK2V617F (JAK2VF) clonal hematopoiesis (CH) have increased JAK/STATsignaling that imparts an increased risk of premature coronary heart disease…”
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Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging by Sonkar, Vijay K., Eustes, Alicia S., Ahmed, Azaj, Jensen, Melissa, Solanki, Mitali V., Swamy, Jagadish, Kumar, Rahul, Fidler, Trevor P., Houtman, Jon C.D., Allen, Bryan G., Spitz, Douglas R., Abel, E. Dale, Dayal, Sanjana

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Erythroid lineage [Jak2.sup.V617F] expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis by Liu, Wenli, Ostberg, Nataliya, Yalcinkaya, Mustafa, Dou, Huijuan, Endo-Umeda, Kaori, Tang, Yang, Hou, Xintong, Xiao, Tong, Fidler, Trevor P, Abramowicz, Sandra, Yang, Yong-Guang, Soehnlein, Oliver, Tall, Alan R, Wang, Nan

“…Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The [JAK2.sup.V617F] ([JAK2.sup.VF]) mutation…”
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