Search Results - "Fidler, Aaron"

The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution by Fidler, Aaron L, Boudko, Sergei P, Rokas, Antonis, Hudson, Billy G

“…The cellular microenvironment, characterized by an extracellular matrix (ECM), played an essential role in the transition from unicellularity to…”
Get full text

Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues by Fidler, Aaron L, Darris, Carl E, Chetyrkin, Sergei V, Pedchenko, Vadim K, Boudko, Sergei P, Brown, Kyle L, Gray Jerome, W, Hudson, Julie K, Rokas, Antonis, Hudson, Billy G

“…The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching…”
Get full text

unique covalent bond in basement membrane is a primordial innovation for tissue evolution by Fidler, Aaron L., Vanacore, Roberto M., Chetyrkin, Sergei V., Pedchenko, Vadim K., Bhave, Gautam, Yin, Viravuth P., Stothers, Cody L., Rose, Kristie Lindsey, McDonald, W. Hayes, Clark, Travis A., Borz, Dorin-Bogdan, Steele, Robert E., Ivy, Michael T., Aspirnauts, The, Hudson, Julie K., Hudson, Billy G.

“…Basement membrane, a specialized ECM that underlies polarized epithelium of eumetazoans, provides signaling cues that regulate cell behavior and function in…”
Get full text

A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes by Pedchenko, Vadim, Bauer, Ryan, Pokidysheva, Elena N., Al-Shaer, Alaa, Forde, Nancy R., Fidler, Aaron L., Hudson, Billy G., Boudko, Sergei P.

“…Collagen IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matrix that is essential for animal multicellularity…”
Get full text

Collagen IVα345 dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture’s and Alport diseases by Pokidysheva, Elena N., Seeger, Harald, Pedchenko, Vadim, Chetyrkin, Sergei, Bergmann, Carsten, Abrahamson, Dale, Cui, Zhao Wei, Delpire, Eric, Fervenza, Fernando C., Fidler, Aaron L., Fogo, Agnes B., Gaspert, Ariana, Grohmann, Maik, Gross, Oliver, Haddad, George, Harris, Raymond C., Kashtan, Clifford, Kitching, A. Richard, Lorenzen, Johan M., McAdoo, Stephen, Pusey, Charles D., Segelmark, Marten, Simmons, Alicia, Voziyan, Paul A., Wagner, Timo, Wüthrich, Rudolf P., Zhao, Ming-Hui, Boudko, Sergei P., Kistler, Andreas D., Hudson, Billy G.

“…Diseases of the glomerular basement membrane (GBM), such as Goodpasture’s disease (GP) and Alport syndrome (AS), are a major cause of chronic kidney failure…”
Get full text

Collagen IV of basement membranes: III. Chloride pressure is a primordial innovation that drives and maintains the assembly of scaffolds by Boudko, Sergei P, Pedchenko, Vadim K, Pokidysheva, Elena N, Budko, Alena M, Baugh, Rachel, Coates, Patrick Toby, Fidler, Aaron L, Hudson, Heather M, Ivanov, Sergey V, Luer, Carl, Pedchenko, Tetyana, Preston, Robert L, Rafi, Mohamed, Vanacore, Roberto, Bhave, Gautam, Hudson, Julie K, Hudson, Billy G

“…Collagen IV scaffold is a primordial innovation enabling the assembly of a fundamental architectural unit of epithelial tissues-a basement membrane attached to…”
Get full text

Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein by Darris, Carl, Revert, Fernando, Revert-Ros, Francisco, Gozalbo-Rovira, Roberto, Feigley, Andrew, Fidler, Aaron, Lopez-Pascual, Ernesto, Saus, Juan, Hudson, Billy G.

“…The emergence of the basement membrane (BM), a specialized form of extracellular matrix, was essential in the unicellular transition to multicellularity…”
Get full text

Engagement of Middle School Students in Discovery Science: A strategy to Elevate Achievement and increase public awareness and appreciation of Science in Rural Communities by Fidler, Aaron, Call, Jaxen, Call, Ricco, Jellison, Lucien, Ward, Braeden, Tate, Rhonda, Hudson, Julie, Hudson, Billy

“…Abstract only Science outreach encompasses many different forms, including science cafes, science festivals, public lectures. These activities afford…”
Get full text

The Evolution of Collagen IV and Basement Membrane Enabling Metazoan Multicellularity by Fidler, Aaron Louis

“…Multicellular life has independently evolved over twenty times from fungi to plants to animals, yet none were as successful and explosive as that of the…”
Get full text

Evolutionary Origin of the Sulfilimine Chemical Bond in Basement Membranes by Fidler, Aaron, Vanacore, Roberto, Pedchenko, Vadim, Bhave, Gautam, Chetyrkin, Sergei, Stothers, Cody, McDonald, Hayes, Rose, Kristie, Aspirnauts, the, Hudson, Julie, Hudson, Billy

“…Abstract only Collagen IV is the primary protein constituent of basement membranes, conferring structural integrity to this specialized form of extracellular…”
Get full text