Search Results - "Ficarro, Scott B"

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding by Twomey, Edward C, Ji, Zhejian, Wales, Thomas E, Bodnar, Nicholas O, Ficarro, Scott B, Marto, Jarrod A, Engen, John R, Rapoport, Tom A

“…The Cdc48 adenosine triphosphatase (ATPase) (p97 or valosin-containing protein in mammals) and its cofactor Ufd1/Npl4 extract polyubiquitinated proteins from…”
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Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes by Park, Eunyoung, Rawson, Shaun, Li, Kunhua, Kim, Byeong-Won, Ficarro, Scott B., Pino, Gonzalo Gonzalez-Del, Sharif, Humayun, Marto, Jarrod A., Jeon, Hyesung, Eck, Michael J.

“…RAF family kinases are RAS-activated switches that initiate signalling through the MAP kinase cascade to control cellular proliferation, differentiation and…”
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Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma by Caro, Pilar, Kishan, Amar U., Norberg, Erik, Stanley, Illana A., Chapuy, Bjoern, Ficarro, Scott B., Polak, Klaudia, Tondera, Daniel, Gounarides, John, Yin, Hong, Zhou, Feng, Green, Michael R., Chen, Linfeng, Monti, Stefano, Marto, Jarrod A., Shipp, Margaret A., Danial, Nika N.

“…Molecular signatures have identified several subsets of diffuse large B cell lymphoma (DLBCL) and rational targets within the B cell receptor (BCR) signaling…”
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LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency by Zhang, Jin, Ratanasirintrawoot, Sutheera, Chandrasekaran, Sriram, Wu, Zhaoting, Ficarro, Scott B., Yu, Chunxiao, Ross, Christian A., Cacchiarelli, Davide, Xia, Qing, Seligson, Marc, Shinoda, Gen, Xie, Wen, Cahan, Patrick, Wang, Longfei, Ng, Shyh-Chang, Tintara, Supisara, Trapnell, Cole, Onder, Tamer, Loh, Yuin-Han, Mikkelsen, Tarjei, Sliz, Piotr, Teitell, Michael A., Asara, John M., Marto, Jarrod A., Li, Hu, Collins, James J., Daley, George Q.

“…The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly…”
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Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II by Suh, Hyunsuk, Ficarro, Scott B., Kang, Un-Beom, Chun, Yujin, Marto, Jarrod A., Buratowski, Stephen

“…Dynamic interactions between RNA polymerase II and various mRNA-processing and chromatin-modifying enzymes are mediated by the changing phosphorylation pattern…”
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Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase by Ji, Zhejian, Li, Hao, Peterle, Daniele, Paulo, Joao A., Ficarro, Scott B., Wales, Thomas E., Marto, Jarrod A., Gygi, Steven P., Engen, John R., Rapoport, Tom A.

“…The hexameric Cdc48 ATPase (p97 or VCP in mammals) cooperates with its cofactor Ufd1/Npl4 to extract polyubiquitinated proteins from membranes or…”
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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C by Hunter, John C., Gurbania, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.

“…Directly targeting oncogenic V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras) with small-molecule inhibitors has historically been considered…”
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Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis by Chu, Nam, Salguero, Antonieta L., Liu, Albert Z., Chen, Zan, Dempsey, Daniel R., Ficarro, Scott B., Alexander, William M., Marto, Jarrod A., Li, Yana, Amzel, L. Mario, Gabelli, Sandra B., Cole, Philip A.

“…Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is activated by C-terminal phosphorylation. The current structural…”
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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype by Olson, Calla M, Liang, Yanke, Leggett, Alan, Park, Woojun D, Li, Lianbo, Mills, Caitlin E, Elsarrag, Selma Z, Ficarro, Scott B, Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A, Sorger, Peter K, Westover, Ken D, Lin, Charles Y, Kwiatkowski, Nicholas, Gray, Nathanael S

“…Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but its precise role remains elusive. We previously described THZ1, a CDK7…”
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BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage by Vohhodina, Jekaterina, Goehring, Liana J., Liu, Ben, Kong, Qing, Botchkarev Jr, Vladimir V., Huynh, Mai, Liu, Zhiqi, Abderazzaq, Fieda O., Clark, Allison P., Ficarro, Scott B., Marto, Jarrod A., Hatchi, Elodie, Livingston, David M.

“…R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause…”
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Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor by Lim, Sang Min, Westover, Kenneth D., Ficarro, Scott B., Harrison, Rane A., Choi, Hwan Geun, Pacold, Michael E., Carrasco, Martin, Hunter, John, Kim, Nam Doo, Xie, Ting, Sim, Taebo, Jänne, Pasi A., Meyerson, Matthew, Marto, Jarrod A., Engen, John R., Gray, Nathanael S.

“…We report the synthesis of a GDP analogue, SML‐8‐73‐1, and a prodrug derivative, SML‐10‐70‐1, which are selective, direct‐acting covalent inhibitors of the…”
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Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation by Joo, Yoo Jin, Ficarro, Scott B, Soares, Luis M, Chun, Yujin, Marto, Jarrod A, Buratowski, Stephen

“…TFIID binds promoter DNA to recruit RNA polymerase II and other basal factors for transcription. Although the TATA-binding protein (TBP) subunit of TFIID is…”
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In vitro analysis of RNA polymerase II elongation complex dynamics by Joo, Yoo Jin, Ficarro, Scott B, Chun, Yujin, Marto, Jarrod A, Buratowski, Stephen

“…RNA polymerase II elongation complexes (ECs) were assembled from nuclear extract on immobilized DNA templates and analyzed by quantitative mass spectrometry…”
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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C by Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W, Ficarro, Scott B, Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M, Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A, Fischer, Eric S, Jänne, Pasi A, Scott, David A, Westover, Kenneth D, Gray, Nathanael S

“…Targeted covalent small molecules have shown promise for cancers driven by KRAS G12C. Allosteric compounds that access an inducible pocket formed by movement…”
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Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1 by Andrawes, Marie Blanke, Xu, Xiang, Liu, Hong, Ficarro, Scott B., Marto, Jarrod A., Aster, Jon C., Blacklow, Stephen C.

“…Notch signaling makes critical contributions to cell fate determination in all metazoan organisms, yet remarkably little is known about the binding affinity of…”
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Accelerating inhibitor discovery for deubiquitinating enzymes by Chan, Wai Cheung, Liu, Xiaoxi, Magin, Robert S., Girardi, Nicholas M., Ficarro, Scott B., Hu, Wanyi, Tarazona Guzman, Maria I., Starnbach, Cara A., Felix, Alejandra, Adelmant, Guillaume, Varca, Anthony C., Hu, Bin, Bratt, Ariana S., DaSilva, Ethan, Schauer, Nathan J., Jaen Maisonet, Isabella, Dolen, Emma K., Ayala, Anthony X., Marto, Jarrod A., Buhrlage, Sara J.

“…Deubiquitinating enzymes (DUBs) are an emerging drug target class of ~100 proteases that cleave ubiquitin from protein substrates to regulate many cellular…”
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Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1 by Tu, Daqi, Zhu, Zehua, Zhou, Alicia Y., Yun, Cai-hong, Lee, Kyung-Eun, Toms, Angela V., Li, Yiqun, Dunn, Gavin P., Chan, Edmond, Thai, Tran, Yang, Shenghong, Ficarro, Scott B., Marto, Jarrod A., Jeon, Hyesung, Hahn, William C., Barbie, David A., Eck, Michael J.

“…Upon stimulation by pathogen-associated inflammatory signals, TANK-binding kinase 1 (TBK1) induces type I interferon expression and modulates nuclear factor κB…”
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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors by Gao, Yang, Zhang, Tinghu, Terai, Hideki, Ficarro, Scott B, Kwiatkowski, Nicholas, Hao, Ming-Feng, Sharma, Bandana, Christensen, Camilla L, Chipumuro, Edmond, Wong, Kwok-Kin, Marto, Jarrod A, Hammerman, Peter S, Gray, Nathanael S, George, Rani E

“…Irreversible inhibition of transcriptional cyclin-dependent kinases (CDKs) provides a therapeutic strategy for cancers that rely on aberrant transcription;…”
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PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair by Hu, Yiduo, Petit, Sarah A, Ficarro, Scott B, Toomire, Kimberly J, Xie, Anyong, Lim, Elgene, Cao, Shiliang A, Park, Eunyoung, Eck, Michael J, Scully, Ralph, Brown, Myles, Marto, Jarrod A, Livingston, David M

“…BRCA1 promotes homologous recombination-mediated DNA repair (HRR). However, HRR must be tightly regulated to prevent illegitimate recombination. We previously…”
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Sub1 and RPA Associate with RNA Polymerase II at Different Stages of Transcription by Sikorski, Timothy W., Ficarro, Scott B., Holik, John, Kim, TaeSoo, Rando, Oliver J., Marto, Jarrod A., Buratowski, Stephen

“…Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their importance during transcription remains unclear. Quantitative…”
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