Search Results - "Ficarra, Paola"
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Enantioselective recognition of 2,3-benzodiazepin-4-one derivatives with anticonvulsant activity on several polysaccharide chiral stationary phases
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (21-06-2006)“…The retention behaviour of racemic 1-(4-aminophenyl)-1,2,3,5-tetrahydro-7,8-methylendioxy-4 H-2,3-benzodiazepin-4-one derivatives with anticonvulsant activity…”
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Improvement in solubility and dissolution rate of flavonoids by complexation with β-cyclodextrin
Published in Journal of pharmaceutical and biomedical analysis (16-04-2004)“…The inclusion into the β-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin…”
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Journal Article Conference Proceeding -
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Amphiphilic cyclodextrins as nanocarriers of genistein: A spectroscopic investigation pointing out the structural properties of the host/drug complex system
Published in Journal of pharmaceutical sciences (01-07-2010)“…Nanoggregates of nonionic amphiphilic cyclodextrin (ACyD) modified with hydrophobic chains of intermediate length…”
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Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with β-cyclodextrin
Published in Bioorganic & medicinal chemistry (15-09-2008)“…The ( R, S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (( R, S)- 1) was previously identified as a potent non-competitive AMPA…”
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Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist
Published in ChemMedChem (16-03-2009)“…2,3‐Benzodiazepine derivatives: 1‐(4‐Aminophenyl)‐3,5‐dihydro‐3‐N‐ethylcarbamoyl‐5‐methyl‐7,8‐methylenedioxy‐4H‐2,3‐benzodiazepin‐4‐one was synthesized, and…”
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Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)‐1‐(4‐aminophenyl)‐7,8‐methylenedioxy‐1,2,3,5‐tetrahydro‐4 H ‐2,3‐benzodiazepin‐4‐one
Published in Chirality (New York, N.Y.) (01-01-2007)“…The resolution of 1‐(4‐aminophenyl)‐7,8‐methylenedioxy‐1,2,3,5‐tetrahydro‐4 H ‐benzodiazepin‐4‐one (±)‐( R , S )‐ 2 was accomplished by chiral HPLC. The…”
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Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one
Published in Chirality (New York, N.Y.) (2007)“…The resolution of 1‐(4‐aminophenyl)‐7,8‐methylenedioxy‐1,2,3,5‐tetrahydro‐4H‐benzodiazepin‐4‐one (±)‐(R,S)‐2 was accomplished by chiral HPLC. The absolute…”
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Variable-ionic strength kinetic experiments in drug stability studies
Published in Journal of pharmaceutical sciences (01-08-2003)“…The dependence of the pseudo-first-order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time,…”
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9th International Meeting on Recent Developments in Pharmaceutical Analysis (RDPA '01)
Published in Journal of pharmaceutical and biomedical analysis (2002)Get full text
Conference Proceeding -
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Temperature-rate profiles by polarimetric variable-temperature kinetic experiments to study racemization reactions
Published in Journal of pharmaceutical and biomedical analysis (01-08-2002)“…The racemization of (−)-adrenaline was followed by polarimetric variable-temperature kinetic experiments obtaining activation parameters and k obs( T) profile…”
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Journal Article Conference Proceeding -
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Nuclear magnetic resonance spectra of psychotherapeutic agents. III.. Stereochemistry of 1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-diones
Published in Journal of heterocyclic chemistry (01-05-1980)“…The stereochemistry of some 1‐methyl‐5‐phenyl‐2,3,4,5‐tetrahydro‐1H‐1,5‐benzodiazepine‐2,4‐diones was determined by proton magnetic resonance using the…”
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Nuclear magnetic resonance spectra of psychotherapeutic agents. III.. Stereochemistry of 1‐methyl‐5‐phenyl‐2,3,4,5‐tetrahydro‐1 H ‐1,5‐benzodiazepine‐2,4‐diones
Published in Journal of heterocyclic chemistry (01-05-1980)“…The stereochemistry of some 1‐methyl‐5‐phenyl‐2,3,4,5‐tetrahydro‐1 H ‐1,5‐benzodiazepine‐2,4‐diones was determined by proton magnetic resonance using the…”
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