Search Results - "Fibbi, G."
-
1
Endothelial Progenitor Cells in Sprouting Angiogenesis: Proteases Pave the Way
Published in Current molecular medicine (01-09-2015)“…Sprouting angiogenesis consists of the expansion and remodelling of existing vessels, where the vascular sprouts connect each other to form new vascular loops…”
Get more information
Journal Article -
2
Type II CRISPR/Cas9 approach in the oncological therapy
Published in Journal of experimental & clinical cancer research (15-06-2017)“…CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect…”
Get full text
Journal Article -
3
u-PAR expression in cancer associated fibroblast: new acquisitions in multiple myeloma progression
Published in BMC cancer (24-03-2017)“…Multiple Myeloma (MM) is a B-cell malignancy in which clonal plasma cells progressively expand within the bone marrow (BM) as effect of complex interactions…”
Get full text
Journal Article -
4
Systemic sclerosis fibroblasts inhibit in vitro angiogenesis by MMP-12-dependent cleavage of the endothelial cell urokinase receptor
Published in The Journal of pathology (01-10-2006)“…Failure of endothelial cells to develop new vessels in response to hypoxia is a distinctive feature of systemic sclerosis (SSc) in the avascular phase. We have…”
Get full text
Journal Article -
5
Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases
Published in Gene therapy (01-04-2005)“…An important factor implicated in tumor cell predisposition for invasion and metastasis is the malignancy-related upregulation of urokinase plasminogen…”
Get full text
Journal Article -
6
Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR-4-dependent up-regulation of urokinase-type plasminogen activator receptor (uPAR, CD87) expression
Published in The Journal of pathology (01-04-2008)“…Here we show the increase of invasion of three breast cancer cell lines (8701-BC, MDA-MB-231 and SKBR3) upon long-term co-incubation with culture medium of…”
Get full text
Journal Article -
7
Deflazacort modulates the fibrinolytic pattern and reduces uPA-dependent chemioinvasion and proliferation in rheumatoid arthritis synoviocytes
Published in Rheumatology (Oxford, England) (01-10-2005)“…Objective. Extracellular fibrinolysis, controlled by the cell-associated fibrinolytic system (urokinase plasminogen activator, uPA; uPA receptor, uPAR;…”
Get full text
Journal Article -
8
Piascledine modulates the production of VEGF and TIMP-1 and reduces the invasiveness of rheumatoid arthritis synoviocytes
Published in Scandinavian journal of rheumatology (01-01-2006)“…Background: In rheumatoid arthritis (RA), hypertrophy of the synovial membrane generates a tumour-like pannus that invades the joint cavity and erodes…”
Get full text
Journal Article -
9
The urokinase-type plasminogen activator system and inflammatory joint diseases
Published in Clinical and experimental rheumatology (01-07-1999)“…Much evidence indicates that the urokinase plasminogen activator (u-PA), the urokinase receptor (u-PAR) and the serpin inhibitors are critical in cell invasion…”
Get full text
Journal Article -
10
Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis
Published in Arthritis research & therapy (01-01-2005)“…Extracellular fibrinolysis, controlled by the membrane-bound fibrinolytic system, is involved in cartilage damage and rheumatoid arthritis (RA) synovitis…”
Get full text
Journal Article -
11
Urokinase-urokinase receptor interaction: non-mitogenic signal transduction in human epidermal cells
Published in Biochemical and biophysical research communications (29-01-1993)“…We studied non-mitogenic signal transduction in a human cell line of epidermal origin which is induced to chemotaxis following stimulation with human…”
Get more information
Journal Article -
12
Transforming Growth Factor Beta-1 Stimulates Invasivity of Hepatic Stellate Cells by Engagement of the Cell-associated Fibrinolytic System
Published in Growth factors (Chur, Switzerland) (2001)“…The activation of hepatic stellate cells (HSC) during liver fibrogenesis has been shown to be mediated by paracrine and autocrine loops involving transforming…”
Get full text
Journal Article -
13
Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells
Published in Experimental cell research (01-12-1988)“…On the basis of 125I-labeled plasminogen activator binding analysis we have found that bovine adrenal capillary endothelial cells have specific receptors for…”
Get more information
Journal Article -
14
-
15
Antisense targeting of the urokinase receptor blocks urokinase-dependent proliferation, chemoinvasion, and chemotaxis of human synovial cells and chondrocytes in vitro
Published in Proceedings of the Association of American Physicians (01-07-1998)“…Proliferation and invasion of synovial pannus in rheumatoid arthritis and cartilage remodeling in osteoarthritis are key events in development of disability of…”
Get more information
Journal Article -
16
Control of the chondrocyte fibrinolytic balance by the drug piroxicam: relevance to the osteoarthritic process
Published in Journal of rheumatology (01-12-1994)“…Since the plasminogen activator [PA/plasminogen activator inhibitor (PAI) system is believed to be involved in a breakdown of articular cartilage in…”
Get more information
Journal Article -
17
Interaction of urokinase A chain with the receptor of human keratinocytes stimulates release of urokinase-like plasminogen activator
Published in Experimental cell research (01-03-1990)“…On the basis of a fibrinolytic assay with 125I-fibrin, zymography, and immunoprobing with anti-human urokinase antibody, we have observed that the in vitro…”
Get more information
Journal Article -
18
Plasminogen activator and receptor in osteoarthritis
Published in Journal of rheumatology. Supplement (01-02-1995)“…Evidence indicates that breakdown of articular cartilage resulting in the loss of normal joint function is the distinctive feature of osteoarthritis…”
Get more information
Journal Article -
19
bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity
Published in The Journal of biological chemistry (20-02-2004)“…We have previously demonstrated that Bcl-2 overexpression in human breast carcinoma and melanoma cells synergizes with hypoxia to increase angiogenesis through…”
Get full text
Journal Article -
20
Multiple pathways of cell invasion are regulated by multiple families of serine proteases
Published in Clinical & experimental metastasis (01-01-2002)“…The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease…”
Get full text
Journal Article