Search Results - "Fialho, Maria da Luz Sousa"

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes by Lopez, Colleen A., Al-Siddiqi, Heba Hussain A. A., Purnama, Ujang, Iftekhar, Sonia, Bruyneel, Arne A. N., Kerr, Matthew, Nazir, Rabia, da Luz Sousa Fialho, Maria, Malandraki-Miller, Sophia, Alonaizan, Rita, Kermani, Fatemeh, Heather, Lisa C., Czernuszka, Jan, Carr, Carolyn A.

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their…”
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L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI by Savic, Dragana, Ball, Vicky, Curtis, M Kate, Sousa Fialho, Maria da Luz, Timm, Kerstin N, Hauton, David, West, James, Griffin, Julian, Heather, Lisa C, Tyler, Damian J

“…The diabetic heart is energetically and metabolically abnormal, with increased fatty acid oxidation and decreased glucose oxidation. One factor contributing to…”
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Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease by Sousa Fialho, Maria da Luz, Abd Jamil, Amira H., Stannard, George A., Heather, Lisa C.

“…Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide, necessitating the development of novel treatments and prevention strategies…”
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Chronic High‐Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria by Perbellini, Filippo, Gomes, Renata S.M., Vieira, Silvia, Buchanan, Dougal, Malandraki-Miller, Sophia, Bruyneel, Arne A.N., Sousa Fialho, Maria da Luz, Ball, Vicky, Clarke, Kieran, Faggian, Giuseppe, Carr, Carolyn A.

“…This study examined the effect of a high‐fat diet on mesenchymal cells from cardiac and adipose tissues. It was found that a high‐fat diet did not affect…”
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Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart by Sousa Fialho, Maria da Luz, Purnama, Ujang, Dennis, Kaitlyn M J H, Montes Aparicio, Claudia N, Castro-Guarda, Marcos, Massourides, Emmanuelle, Tyler, Damian J, Carr, Carolyn A, Heather, Lisa C

“…Type 2 diabetes (T2D) impairs hypoxia-inducible factor (HIF)1α activation, a master transcription factor that drives cellular adaptation to hypoxia. Reduced…”
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The challenge of ensuring affordability, sustainability, consistency, and adaptability in the common metrics agenda by Krause, Karolin Rose, Chung, Sophie, Sousa Fialho, Maria da Luz, Szatmari, Peter, Wolpert, Miranda

“…Mental health research grapples with research waste and stunted field progression caused by inconsistent outcome measurement across studies and clinical…”
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Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation by Mansor, Latt S, Sousa Fialho, Maria da Luz, Yea, Georgina, Coumans, Will A, West, James A, Kerr, Matthew, Carr, Carolyn A, Luiken, Joost J F P, Glatz, Jan F C, Evans, Rhys D, Griffin, Julian L, Tyler, Damian J, Clarke, Kieran, Heather, Lisa C

“…The type 2 diabetic heart oxidizes more fat and less glucose, which can impair metabolic flexibility and function. Increased sarcolemmal fatty acid translocase…”
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Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation by Mansor, Latt S., Mehta, Keshavi, Aksentijevic, Dunja, Carr, Carolyn A., Lund, Trine, Cole, Mark A., Page, Lydia Le, Sousa Fialho, Maria da Luz, Shattock, Michael J., Aasum, Ellen, Clarke, Kieran, Tyler, Damian J, Heather, Lisa C.

“…Key points Adaptation to hypoxia makes the heart more oxygen efficient, by metabolising more glucose. In contrast, type 2 diabetes makes the heart metabolise…”
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International consensus on patient-centred outcomes in eating disorders by Austin, Amelia, De Silva, Umanga, Ilesanmi, Christiana, Likitabhorn, Theerawich, Miller, Isabel, Sousa Fialho, Maria da Luz, Austin, S Bryn, Caldwell, Belinda, Chew, Chu Shan Elaine, Chua, Sook Ning, Dooley-Hash, Suzanne, Downs, James, El Khazen Hadati, Carine, Herpertz-Dahlmann, Beate, Lampert, Jillian, Latzer, Yael, Machado, Paulo P P, Maguire, Sarah, Malik, Madeeha, Moser, Carolina Meira, Myers, Elissa, Pastor, Iris Ruth, Russell, Janice, Smolar, Lauren, Steiger, Howard, Tan, Elizabeth, Trujillo-Chi Vacuán, Eva, Tseng, Mei-Chih Meg, van Furth, Eric F, Wildes, Jennifer E, Peat, Christine, Richmond, Tracy K

“…The effectiveness of mental health care can be improved through coordinated and wide-scale outcome measurement. The International Consortium for Health…”
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Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes by Dodd, Michael S., PhD, Sousa Fialho, Maria da Luz, MSc, Montes Aparicio, Claudia N., MSc, Kerr, Matthew, MSc, Timm, Kerstin N., PhD, Griffin, Julian L., PhD, Luiken, Joost J.F.P., PhD, Glatz, Jan F.C., PhD, Tyler, Damian J., PhD, Heather, Lisa C., PhD

“…Visual Abstract…”
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International Consensus on Standard Outcome Measures for Neurodevelopmental Disorders: A Consensus Statement by Mulraney, Melissa, de Silva, Umanga, Joseph, Andria, Sousa Fialho, Maria da Luz, Dutia, Iain, Munro, Natalie, Payne, Jonathan M, Banaschewski, Tobias, de Lima, Cláudia Bandeira, Bellgrove, Mark A, Chamberlain, Samuel R, Chan, Phyllis, Chong, Ivy, Clink, Alison, Cortese, Samuele, Daly, Eileen, Faraone, Stephen V, Gladstone, Melissa, Guastella, Adam J, Järvdike, Juulia, Kaleem, Sidra, Lovell, Mark G, Meller, Tamasin, Nagy, Peter, Newcorn, Jeffrey H, Polanczyk, Guilherme V, Simonoff, Emily, Szatmari, Peter, Tehan, Caroline, Walsh, Karin, Wamithi, Susan, Coghill, David

“…The use of evidence-based standardized outcome measures is increasingly recognized as key to guiding clinical decision-making in mental health. Implementation…”
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Pharmacological manipulation of hypoxic signalling as a therapeutic target to improve metabolism and function in the type 2 diabetic heart by Fialho, Maria da Luz Sousa

“…The work presented in this thesis investigates the metabolic and functional benefits of metabolic modulatory treatment strategies in a rodent model of type 2…”
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