Search Results - "Fialho, Luz Sousa"
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1
Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes
Published in Scientific reports (08-04-2021)“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their…”
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2
Balancing adaptability and standardisation: insights from 27 routinely implemented ICHOM standard sets
Published in BMC health services research (28-11-2022)“…Healthcare systems around the world experience increasing pressure to control future growth of healthcare expenditures. Among other initiatives, quality and…”
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3
Standard set of patient-reported outcomes for personality disorder
Published in Quality of life research (01-12-2021)“…Purpose The purpose of the article is to present standard set of outcomes for people with personality disorder (PD), in order to facilitate patient outcome…”
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4
Developing an International Standard Set of Patient-Reported Outcome Measures for Psychotic Disorders
Published in Psychiatric services (Washington, D.C.) (01-03-2022)“…Objective:The objective of this project was to develop a set of patient-reported outcome measures for adolescents and adults who meet criteria for a psychotic…”
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5
Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Adults with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations
Published in Epilepsia (Copenhagen) (01-07-2024)“…At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. Therefore, the International…”
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Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Infants, Children, and Adolescents with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations
Published in Epilepsia (Copenhagen) (01-07-2024)“…At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. The International Consortium for…”
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7
L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI
Published in Metabolites (23-03-2021)“…The diabetic heart is energetically and metabolically abnormal, with increased fatty acid oxidation and decreased glucose oxidation. One factor contributing to…”
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An International, Multidisciplinary Consensus Set of Patient-Centered Outcome Measures for Substance-Related and Addictive Disorders
Published in Journal of clinical medicine (01-04-2024)“…In 1990, the United States' Institute of Medicine promoted the principles of outcomes monitoring in the alcohol and other drugs treatment field to improve the…”
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9
Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease
Published in Biochimica et biophysica acta. Molecular basis of disease (01-04-2019)“…Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide, necessitating the development of novel treatments and prevention strategies…”
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10
Chronic High‐Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria
Published in Stem cells translational medicine (01-12-2015)“…This study examined the effect of a high‐fat diet on mesenchymal cells from cardiac and adipose tissues. It was found that a high‐fat diet did not affect…”
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11
Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart
Published in Diabetes (New York, N.Y.) (01-11-2021)“…Type 2 diabetes (T2D) impairs hypoxia-inducible factor (HIF)1α activation, a master transcription factor that drives cellular adaptation to hypoxia. Reduced…”
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12
The challenge of ensuring affordability, sustainability, consistency, and adaptability in the common metrics agenda
Published in The Lancet. Psychiatry (01-12-2021)“…Mental health research grapples with research waste and stunted field progression caused by inconsistent outcome measurement across studies and clinical…”
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13
Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation
Published in Cardiovascular research (01-06-2017)“…The type 2 diabetic heart oxidizes more fat and less glucose, which can impair metabolic flexibility and function. Increased sarcolemmal fatty acid translocase…”
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14
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation
Published in The Journal of physiology (15-01-2016)“…Key points Adaptation to hypoxia makes the heart more oxygen efficient, by metabolising more glucose. In contrast, type 2 diabetes makes the heart metabolise…”
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15
International consensus on patient-centred outcomes in eating disorders
Published in The Lancet. Psychiatry (01-12-2023)“…The effectiveness of mental health care can be improved through coordinated and wide-scale outcome measurement. The International Consortium for Health…”
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16
Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes
Published in JACC. Basic to translational science (01-08-2018)“…Visual Abstract…”
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17
International Consensus on Standard Outcome Measures for Neurodevelopmental Disorders: A Consensus Statement
Published in JAMA network open (03-06-2024)“…The use of evidence-based standardized outcome measures is increasingly recognized as key to guiding clinical decision-making in mental health. Implementation…”
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Development of an international standard set of outcome measures for patients with venous thromboembolism: an International Consortium for Health Outcomes Measurement consensus recommendation
Published in The Lancet. Haematology (01-09-2022)“…The International Consortium for Health Outcomes Measurement assembled an international working group of venous thromboembolism experts and patient…”
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19
Pharmacological manipulation of hypoxic signalling as a therapeutic target to improve metabolism and function in the type 2 diabetic heart
Published 01-01-2018“…The work presented in this thesis investigates the metabolic and functional benefits of metabolic modulatory treatment strategies in a rodent model of type 2…”
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Dissertation