Search Results - "Ffrench‐Constant, Charles"

Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain by Bechler, Marie E., Swire, Matthew, ffrench‐Constant, Charles

“…ABSTRACT The concept of adaptive myelination—myelin plasticity regulated by activity—is an important advance for the field. What signals set up the adaptable…”
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Extracellular matrix and the neural stem cell niche by Kazanis, Ilias, ffrench‐Constant, Charles

“…Basal lamina is present in many stem cell niches, but we still have a poor understanding of the role of this and other extracellular matrix (ECM) components…”
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Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes by Seiberlich, Veronika, Bauer, Nina G., Schwarz, Lisa, Ffrench-Constant, Charles, Goldbaum, Olaf, Richter-Landsberg, Christiane

“…Oligodendrocytes, the myelin forming cells of the CNS, are characterized by their numerous membranous extensions, which enwrap neuronal axons and form myelin…”
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Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP‐Dependent Regulation by Ong, William, Marinval, Nicolas, Lin, Junquan, Nai, Mui Hoon, Chong, Yee‐Song, Pinese, Coline, Sajikumar, Sreedharan, Lim, Chwee Teck, Ffrench‐Constant, Charles, Bechler, Marie E., Chew, Sing Yian

“…A key hallmark of many diseases, especially those in the central nervous system (CNS), is the change in tissue stiffness due to inflammation and scarring…”
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Role of the oligodendroglial cytoskeleton in differentiation and myelination by Bauer, Nina G., Richter-Landsberg, Christiane, Ffrench-Constant, Charles

“…Oligodendrocytes, the myelin‐forming cells of the central nervous system, are in culture characterized by an elaborate process network, terminating in flat…”
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The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions by Ulc, Annika, Zeug, Andre, Bauch, Juliane, Leeuwen, Simon, Kuhlmann, Tanja, ffrench‐Constant, Charles, Ponimaskin, Evgeni, Faissner, Andreas

“…The tightly controlled processes of myelination and remyelination require the participation of the cytoskeleton. The reorganization of the cytoskeleton is…”
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Adherens junction domains are split by asymmetric division of embryonic neural stem cells by Marthiens, Véronique, ffrench-Constant, Charles

“…Investigating the mechanisms controlling the asymmetric division of neocortical progenitors that generate neurones in the mammalian brain is crucial for…”
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The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2 by Jarjour, Andrew A., Velichkova, Atanaska N., Boyd, Amanda, Lord, Kathryn M., Torsney, Carole, Henderson, Deborah J., ffrench‐Constant, Charles

“…During axonal ensheathment, noncompact myelin channels formed at lateral edges of the myelinating process become arranged into tight paranodal spirals that…”
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Hypomyelinating leukodystrophies: Translational research progress and prospects by Pouwels, Petra J. W., Vanderver, Adeline, Bernard, Genevieve, Wolf, Nicole I., Dreha-Kulczewksi, Steffi F., Deoni, Sean C. L., Bertini, Enrico, Kohlschütter, Alfried, Richardson, William, ffrench-Constant, Charles, Köhler, Wolfgang, Rowitch, David, Barkovich, A. James

“…Hypomyelinating leukodystrophies represent a genetically heterogeneous but clinically overlapping group of heritable disorders. Current management approaches…”
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PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS by Nieuwenhuis, Bart, Barber, Amanda C, Evans, Rachel S, Pearson, Craig S, Fuchs, Joachim, MacQueen, Amy R, van Erp, Susan, Haenzi, Barbara, Hulshof, Lianne A, Osborne, Andrew, Conceicao, Raquel, Khatib, Tasneem Z, Deshpande, Sarita S, Cave, Joshua, Ffrench‐Constant, Charles, Smith, Patrice D, Okkenhaug, Klaus, Eickholt, Britta J, Martin, Keith R, Fawcett, James W, Eva, Richard

“…Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after…”
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Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway by Czopka, Tim, Von Holst, Alexander, Schmidt, Gudula, Ffrench-Constant, Charles, Faissner, Andreas

“…Membrane formation and the initiation of myelin gene expression are hallmarks of the differentiation of oligodendrocytes from their precursors. Here, we…”
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Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells by Setzu, Anna, Lathia, Justin D., Zhao, Chao, Wells, Karen, Rao, Mahendra S., ffrench-Constant, Charles, Franklin, Robin J. M.

“…Inflammation associated with CNS demyelination provides an important stimulus for the activation of endogenous oligodendrocyte precursor cells (OPCs) and…”
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Patterns of laminins and integrins in the embryonic ventricular zone of the CNS by Lathia, Justin D., Patton, Bruce, Eckley, D. Mark, Magnus, Tim, Mughal, Mohamed R., Sasaki, Takako, Caldwell, Maeve A., Rao, Mahendra S., Mattson, Mark P., ffrench-Constant, Charles

“…The extracellular matrix (ECM) provides both a physical framework and a microenvironment that supplies instructive signals from the earliest stages of…”
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Laminin enhances the growth of human neural stem cells in defined culture media by Hall, Peter E, Lathia, Justin D, Caldwell, Maeve A, Ffrench-Constant, Charles

“…Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and…”
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Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa by Megaw, Roly, Dr, Mellough, Carla, PhD, Wright, Alan, Prof, Lako, Majlinda, Prof, ffrench-Constant, Charles, Prof

“…Abstract Background Retinitis pigmentosa, which affects one in 3000 people, causes blindness and has no treatment. Mutations in the retinitis pigmentosa GTPase…”
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CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes by Bechler, Marie E., Byrne, Lauren, ffrench-Constant, Charles

“…Since Río-Hortega’s description of oligodendrocyte morphologies nearly a century ago, many studies have observed myelin sheath-length diversity between CNS…”
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The microenvironment of the embryonic neural stem cell: Lessons from adult niches? by Lathia, Justin D., Rao, Mahendra S., Mattson, Mark P., ffrench‐Constant, Charles

“…A better understanding of the signals regulating embryonic neural stem cells is clearly an important goal. However, many studies on neural stem cell biology…”
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Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration by Raven, Alexander, Lu, Wei-Yu, Man, Tak Yung, Ferreira-Gonzalez, Sofia, O’Duibhir, Eoghan, Dwyer, Benjamin J., Thomson, John P., Meehan, Richard R., Bogorad, Roman, Koteliansky, Victor, Kotelevtsev, Yuri, ffrench-Constant, Charles, Boulter, Luke, Forbes, Stuart J.

“…Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration…”
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Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis by Falcão, Ana Mendanha, van Bruggen, David, Marques, Sueli, Meijer, Mandy, Jäkel, Sarah, Agirre, Eneritz, Samudyata, Floriddia, Elisa M., Vanichkina, Darya P., ffrench-Constant, Charles, Williams, Anna, Guerreiro-Cacais, André Ortlieb, Castelo-Branco, Gonçalo

“…Multiple sclerosis (MS) is characterized by an immune system attack targeting myelin, which is produced by oligodendrocytes (OLs). We performed single-cell…”
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The extracellular matrix glycoprotein Tenascin-C is expressed by oligodendrocyte precursor cells and required for the regulation of maturation rate, survival and responsiveness to platelet-derived growth factor by Garwood, Jeremy, Garcion, Emmanuel, Dobbertin, Alexandre, Heck, Nicolas, Calco, Valerie, Ffrench-Constant, Charles, Faissner, Andreas

“…Analysis of Tenascin‐C (TN‐C) knockout mice revealed novel roles for this extracellular matrix (ECM) protein in regulation of the developmental programme of…”
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