Search Results - "Ffrench, Charlie B."
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Desmoglein-2 is important for islet function and β-cell survival
Published in Cell death & disease (29-10-2022)“…Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune…”
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Desmoglein-2 as a cancer modulator: friend or foe?
Published in Frontiers in oncology (2023)“…Desmoglein-2 (DSG2) is a calcium-binding single pass transmembrane glycoprotein and a member of the large cadherin family. Until recently, DSG2 was thought to…”
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Overcoming the Fibrotic Fortress in Pancreatic Ductal Adenocarcinoma: Challenges and Opportunities
Published in Cancers (18-04-2023)“…An overabundance of desmoplasia in the tumour microenvironment (TME) is one of the defining features that influences pancreatic ductal adenocarcinoma (PDAC)…”
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Abstract A073: Desmoglein-2 is a regulator of pancreatic ductal adenocarcinoma progression
Published in Cancer research (Chicago, Ill.) (15-09-2024)“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a dismal 5-year survival rate of <13%. We have discovered that…”
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