Search Results - "Feyrer, H"
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Optimising in-cell NMR acquisition for nucleic acids
Published in Journal of biomolecular NMR (20-08-2024)“…Understanding the structure and function of nucleic acids in their native environment is crucial to structural biology and one focus of in-cell NMR…”
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Enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR
Published in PloS one (08-07-2022)“…Solution NMR spectroscopy is a well-established tool with unique advantages for structural studies of RNA molecules. However, for large RNA sequences, the NMR…”
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One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts
Published in Molecules (Basel, Switzerland) (04-03-2020)“…There is an increasing demand for efficient and robust production of short RNA molecules in both pharmaceutics and research. A standard method is transcription…”
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Mass Spectrometry of RNA-Binding Proteins during Liquid–Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
Published in Journal of the American Chemical Society (17-05-2023)“…Liquid–liquid phase separation (LLPS) of heterogeneous ribonucleoproteins (hnRNPs) drives the formation of membraneless organelles, but structural information…”
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5
Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage
Published in Biophysical journal (04-06-2019)“…Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have…”
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6
Broadband RF‐amplitude‐dependent flip angle pulses with linear phase slope
Published in Magnetic resonance in chemistry (01-09-2017)“…Pulse sequences in NMR spectroscopy sometimes require the application of pulses with effective flip angles different from 90° and 180°. Previously (Magn…”
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Mass Spectrometry and Molecular Dynamics Simulations Untangles Structure and Function of Protein Condensates
Published in PROTEIN SCIENCE (2023)Get full text
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