Search Results - "Fey, Sigrid K."

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response by McGregor, Grace H, Campbell, Andrew D, Fey, Sigrid K, Tumanov, Sergey, Sumpton, David, Blanco, Giovanny Rodriguez, Mackay, Gillian, Nixon, Colin, Vazquez, Alexei, Sansom, Owen J, Kamphorst, Jurre J

“…Statins are widely prescribed inhibitors of the mevalonate pathway, acting to lower systemic cholesterol levels. The mevalonate pathway is critical for…”
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Dark force rising: Reawakening and targeting of fetal-like stem cells in colorectal cancer by Fey, Sigrid K., Vaquero-Siguero, Nuria, Jackstadt, Rene

“…Stem cells play pivotal roles in maintaining intestinal homeostasis, orchestrating regeneration, and in key steps of colorectal cancer (CRC) initiation and…”
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KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo by Najumudeen, Arafath K., Fey, Sigrid K., Millett, Laura M., Ford, Catriona A., Gilroy, Kathryn, Gunduz, Nuray, Ridgway, Rachel A., Anderson, Eve, Strathdee, Douglas, Clark, William, Nixon, Colin, Morton, Jennifer P., Campbell, Andrew D., Sansom, Owen J.

“…Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic…”
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Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition by Sharbeen, George, McCarroll, Joshua A, Akerman, Anouschka, Kopecky, Chantal, Youkhana, Janet, Kokkinos, John, Holst, Jeff, Boyer, Cyrille, Erkan, Mert, Goldstein, David, Timpson, Paul, Cox, Thomas R, Pereira, Brooke A, Chitty, Jessica L, Fey, Sigrid K, Najumudeen, Arafath K, Campbell, Andrew D, Sansom, Owen J, Ignacio, Rosa Mistica C, Naim, Stephanie, Liu, Jie, Russia, Nelson, Lee, Julia, Chou, Angela, Johns, Amber, Gill, Anthony J, Gonzales-Aloy, Estrella, Gebski, Val, Guan, Yi Fang, Pajic, Marina, Turner, Nigel, Apte, Minoti V, Davis, Thomas P, Morton, Jennifer P, Haghighi, Koroush S, Kasparian, Jorjina, McLean, Benjamin J, Setargew, Yordanos F, Phillips, Phoebe A

“…Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the generation…”
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KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition by Fey, Sigrid K, Najumudeen, Arafath K, Watt, Dale M, Millett, Laura M, Ford, Catriona A, Gilroy, Kathryn, Simpson, Rosalin J, McLay, Kathy, Upstill-Goddard, Rosanna, Chang, David, Clark, William, Nixon, Colin, Birch, Joanna L, Barry, Simon T, Morton, Jennifer P, Campbell, Andrew D, Sansom, Owen J

“…Pancreatic cancer is characterized by the prevalence of oncogenic mutations in KRAS. Previous studies have reported that altered KRAS gene dosage drives…”
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The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer by Najumudeen, Arafath K., Ceteci, Fatih, Fey, Sigrid K., Hamm, Gregory, Steven, Rory T., Hall, Holly, Nikula, Chelsea J., Dexter, Alex, Murta, Teresa, Race, Alan M., Sumpton, David, Vlahov, Nikola, Gay, David M., Knight, John R. P., Jackstadt, Rene, Leach, Joshua D. G., Ridgway, Rachel A., Johnson, Emma R., Nixon, Colin, Hedley, Ann, Gilroy, Kathryn, Clark, William, Malla, Sudhir B., Dunne, Philip D., Rodriguez-Blanco, Giovanny, Critchlow, Susan E., Mrowinska, Agata, Malviya, Gaurav, Solovyev, Dmitry, Brown, Gavin, Lewis, David Y., Mackay, Gillian M., Strathdee, Douglas, Tardito, Saverio, Gottlieb, Eyal, Takats, Zoltan, Barry, Simon T., Goodwin, Richard J. A., Bunch, Josephine, Bushell, Martin, Campbell, Andrew D., Sansom, Owen J.

“…Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most…”
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Abstract A004: KRAS allelic imbalance drives an epithelial MAPK-dependent tumor initiation program that is inefficient in provoking metastasis in colorectal cancer in vivo by Najumudeen, Arafath K., Fey, Sigrid K., Campbell, Andrew D., Sansom, Owen J.

“…Abstract Allelic imbalance is reported to be a frequent event in cancers and a common feature associated with oncogenes such as KRAS and BRAF. However the…”
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