Search Results - "Fevig, Thomas L."

Radical reactions in natural product synthesis by Jasperse, Craig P, Curran, Dennis P, Fevig, Thomas L

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Design, Synthesis, and in Vitro Evaluation of Cyclic Nitrones as Free Radical Traps for the Treatment of Stroke by Fevig, Thomas L, Bowen, S. Marc, Janowick, David A, Jones, Bryan K, Munson, H. Randall, Ohlweiler, David F, Thomas, Craig E

“…Analogs of the cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4-dihydroisoquinoline N-oxide, a cyclic analog of phenyl-tert-butylnitrone (PBN)) were…”
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A Novel and Expeditious Approach to Thiophene-3-carboxylates by Fevig, Thomas L, Phillips, W. Gary, Lau, Patrick H

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Asymmetric synthesis of ENT-03, the predicted mammalian ortholog of the dog fish shark aminosterol trodusquemine (MSI-1436) by Kinney, William A., Phillip Cox, D., Jones, Stephen R., Hessler, Edward J., Karnes, Harold A., Fevig, Thomas L., Hewitt, Bradley D., Sullivan, Ryan, Tseng, Nai-Wen, Pasion, Edward, Beale, Thomas, Rosner, Thorsten, Crouch, Ian T., D’Ambrosio, Stephen, Wade, Peter, Chen, Hui, Gao, Qi, Thompson, Andrew S., Muzzio, Miguel, Barbut, Denise, Zasloff, Michael A.

“…[Display omitted] ENT-03 was predicted to be the mammalian equivalent of trodusquemine, based on knowledge of the bile acids produced in mammals, such as…”
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A samarium(II) iodide promoted tandem radical cyclization. The total synthesis of (.+-.)-hypnophilin and the formal synthesis of (.+-.)-coriolin by Fevig, Thomas L, Elliott, Richard L, Curran, Dennis P

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Process Research on the Synthesis of Silthiofam:  A Novel Fungicide for Wheat by Phillips, Fevig, Thomas L, Lau, Patrick H, Klemm, George H, Mao, Michael K, Ma, Chun, Gloeckner, James A, Clark, Art S

“…The development of an efficient, low-cost synthesis of the novel wheat fungicide silthiofam (1) is described. Improvements to the original Discovery route…”
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Cyclic Nitrone Free Radical Traps:  Isolation, Identification, and Synthesis of 3,3-Dimethyl-3,4-dihydroisoquinolin-4-ol N-Oxide, a Metabolite with Reduced Side Effects by Thomas, Craig E, Bernardelli, Patrick, Bowen, S. Marc, Chaney, Stephen F, Friedrich, Dirk, Janowick, David A, Jones, Bryan K, Keeley, Frederick J, Kehne, John H, Ketteler, Bert, Ohlweiler, David F, Paquette, Leo A, Robke, David J, Fevig, Thomas L

“…A C-4 hydroxylated metabolite (2, 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide) of the previously described cyclic nitrone free radical trap 1…”
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Enzymatic resolution for an improved enantioselective synthesis of benzofuranyl derivatives: precursors to a class of vitamin E related antioxidants by Ayers, Timothy A., Schnettler, Richard A., Marciniak, Gilbert, Stewart, Kenneth T., Mishra, Rajesh K., Krysan, Damian J., Bernas, Bradley R., Bhardwaj, Poonam, Fevig, Thomas L.

“…Enzymatic resolution of 3-hydroxymethylbenzofurans using Candida rugosa lipase provides an enantioselective synthesis of vitamin E related antioxidants…”
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A short, stereoselective route to 16.alpha.-(substituted-alkyl)estradiol derivatives by Fevig, Thomas L, Katzenellenbogen, John A

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Preparation, receptor binding, and fluorescence properties of hexestrol-fluorophore conjugates: evaluation of site of attachment, fluorophore structure, and fluorophore-ligand spacing by Fevig, Thomas L, Lloyd, John E, Zablocki, Jeffery A, Katzenellenbogen, John A

“…We have undertaken a staged development of certain estrogen-fluorophore conjugates, in order to prepare a fluorescent estrogen suitable for determination of…”
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Estrogen receptor binding tolerance of 16 alpha-substituted estradiol derivatives by Fevig, T L, Mao, M K, Katzenellenbogen, J A

“…In order to examine the tolerance of the estrogen receptor for 16 alpha-substituents in estradiol, we have synthesized various 16 alpha-substituted estrogens…”
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