Search Results - "Feun, Lynn G."

Single-cell analysis reveals new evolutionary complexity in uveal melanoma by Durante, Michael A., Rodriguez, Daniel A., Kurtenbach, Stefan, Kuznetsov, Jeffim N., Sanchez, Margaret I., Decatur, Christina L., Snyder, Helen, Feun, Lynn G., Livingstone, Alan S., Harbour, J. William

“…Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we…”
Get full text

Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced, unresectable hepatocellular carcinoma by Feun, Lynn G., Li, Ying‐Ying, Wu, Chunjing, Wangpaichitr, Medhi, Jones, Patricia D., Richman, Stephen P., Madrazo, Beatrice, Kwon, Deukwoo, Garcia‐Buitrago, Monica, Martin, Paul, Hosein, Peter J., Savaraj, Niramol

“…Background Checkpoint inhibitors have shown modest activity in patients with advanced hepatocellular carcinoma (HCC). Herein, the authors report a prospective…”
Get full text

First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma by Kim, Richard D, Sarker, Debashis, Meyer, Tim, Yau, Thomas, Macarulla, Teresa, Park, Joong-Won, Choo, Su Pin, Hollebecque, Antoine, Sung, Max W, Lim, Ho-Yeong, Mazzaferro, Vincenzo, Trojan, Joerg, Zhu, Andrew X, Yoon, Jung-Hwan, Sharma, Sunil, Lin, Zhong-Zhe, Chan, Stephen L, Faivre, Sandrine, Feun, Lynn G, Yen, Chia-Jui, Dufour, Jean-Francois, Palmer, Daniel H, Llovet, Josep M, Manoogian, Melissa, Tugnait, Meera, Stransky, Nicolas, Hagel, Margit, Kohl, Nancy E, Lengauer, Christoph, Sherwin, Cori Ann, Schmidt-Kittler, Oleg, Hoeflich, Klaus P, Shi, Hongliang, Wolf, Beni B, Kang, Yoon-Koo

“…Outcomes for patients with advanced hepatocellular carcinoma (HCC) remain poor despite recent progress in drug development. Emerging data implicate FGF19 as a…”
Get more information

Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005 by Ji, Yongli, Rankin, Cathryn, Grunberg, Steven, Sherrod, Andy E, Ahmadi, Jamshid, Townsend, Jeannette J, Feun, Lynn G, Fredericks, Ruth K, Russell, Christy A, Kabbinavar, Fairooz F, Stelzer, Keith J, Schott, Anne, Verschraegen, Claire

“…Progesterone receptors are expressed in approximately 70% of meningiomas. Mifepristone is an oral antiprogestational agent reported to have modest activity in…”
Get full text

Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration by Wangpaichitr, Medhi, Theodoropoulos, George, Nguyen, Dan J M, Wu, Chunjing, Spector, Sydney A, Feun, Lynn G, Savaraj, Niramol

“…The development of drug resistance in tumors is a major obstacle to effective cancer chemotherapy and represents one of the most significant complications to…”
Get full text

Targeting the Proline-Glutamine-Asparagine-Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy by Kuo, Macus Tien, Chen, Helen H W, Feun, Lynn G, Savaraj, Niramol

“…Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the…”
Get full text

Enhancing the Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Signaling and Arginine Deprivation in Melanoma by Wu, Chunjing, You, Min, Nguyen, Dao, Wangpaichitr, Medhi, Li, Ying-Ying, Feun, Lynn G., Kuo, Macus T., Savaraj, Niramol

“…Melanoma as a very aggressive type of cancer is still in urgent need of improved treatment. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and…”
Get full text

The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells by Wangpaichitr, Medhi, Sullivan, Elizabeth J, Theodoropoulos, George, Wu, Chunjing, You, Min, Feun, Lynn G, Lampidis, Theodore J, Kuo, Macus T, Savaraj, Niramol

“…Elimination of cisplatin-resistant lung cancer cells remains a major obstacle. We have shown that cisplatin-resistant tumors have higher reactive oxygen…”
Get full text

Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy by Li, Ying-Ying, Feun, Lynn G, Thongkum, Angkana, Tu, Chiao-Hui, Chen, Shu-Mei, Wangpaichitr, Medhi, Wu, Chunjing, Kuo, Macus T, Savaraj, Niramol

“…Autophagy, a self-eating machinery, has been reported as an adaptive response to maintain metabolic homeostasis when cancer cells encounter stress. It has been…”
Get full text

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors by Kuo, Macus Tien, Long, Yan, Tsai, Wen-Bin, Li, Ying-Ying, Chen, Helen H.W., Feun, Lynn G., Savaraj, Niramol

“…Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1…”
Get full text

Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer by Wu, Chunjing, Spector, Sydney A, Theodoropoulos, George, Nguyen, Dan J M, Kim, Emily Y, Garcia, Ashley, Savaraj, Niramol, Lim, Diane C, Paul, Ankita, Feun, Lynn G, Bickerdike, Michael, Wangpaichitr, Medhi

“…The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have…”
Get full text

Degradation of AMPK‐α1 sensitizes BRAF inhibitor‐resistant melanoma cells to arginine deprivation by Li, Ying‐Ying, Wu, Chunjing, Shah, Sumedh S., Chen, Shu‐Mei, Wangpaichitr, Medhi, Kuo, Macus T., Feun, Lynn G., Han, Xiaoqing, Suarez, Miguel, Prince, Jeffrey, Savaraj, Niramol

“…Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with BRAF inhibitors (BRAFi) despite a high initial response rate…”
Get full text

Pegylated Arginine Deiminase Treatment of Patients With Metastatic Melanoma: Results From Phase I and II Studies by ASCIERTO, Paolo A, SCALA, Stefania, ENSOR, C. Mark, PRESTAYKO, Archie W, HOLTSBERG, Frederick W, BOMALASKI, John S, CLARK, Mike A, SAVARAJ, Niramol, FEUN, Lynn G, LOGAN, Theodore F, CASTELLO, Giuseppe, DAPONTE, Antonio, SIMEONE, Ester, OTTAIANO, Alessandro, BENEDUCE, Gerardo, DE ROSA, Vincenzo, IZZO, Francesco, MELUCCI, Maria Teresa

“…Individuals with metastatic melanoma have a poor prognosis. Many human melanomas are auxotrophic for arginine, and arginine is not an essential amino acid in…”
Get full text

Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy by Chen, Helen H W, Chen, Wen-Chung, Liang, Zhang-Dong, Tsai, Wen-Bin, Long, Yan, Aiba, Isamu, Fu, Siqing, Broaddus, Russell, Liu, Jinsong, Feun, Lynn G, Savaraj, Niramol, Kuo, Macus Tien

“…Platinum (Pt)-based antitumor agents remain important chemotherapeutic agents for treating many human malignancies. Elevated expression of the human…”
Get more information

Topoisomerase I inhibitors in the treatment of primary CNS malignancies: an update on recent trends by Sasine, Joshua P, Savaraj, Niramol, Feun, Lynn G

“…High grade primary CNS gliomas hold some of the worst prognoses of any malignancy, with the vast majority of patients dying within two years of diagnosis, even…”
Get more information

Liver Transplantation for Hepatocellular Carcinoma in the Model for End-Stage Liver Disease Era by Levi, David M., MD, FACS, Tzakis, Andreas G., MD, PhD, FACS, Martin, Paul, MD, Nishida, Seigo, MD, PhD, FACS, Island, Eddie, MD, FACS, Moon, Jang, MD, Selvaggi, Gennaro, MD, Tekin, Akin, MD, Madrazo, Beatrice L., MD, Narayanan, Govindarajan, MD, Garcia, Monica T., MD, Feun, Lynn G., MD, Tryphonopoulos, Panagiotis, MD, Skartsis, Nikolaos, MD, Livingstone, Alan S., MD, FACS

“…Background Since March 2002, the United Network for Organ Sharing liver allocation policy has given extra priority to patients with hepatocellular carcinoma…”
Get full text

Arginine deprivation in cancer therapy by Feun, Lynn G, Kuo, Macus Tien, Savaraj, Niramol

“…PURPOSE OF REVIEWThere has been an increased and renewed interest in metabolic therapy for cancer, particularly Arg deprivation. The purpose of this review is…”
Get full text

Optical coherence tomography imaging of melanoma skin cancer by Rajabi-Estarabadi, Ali, Bittar, Julie M., Zheng, Caiwei, Nascimento, Vanessa, Camacho, Isabella, Feun, Lynn G., Nasiriavanaki, Mohammadreza, Kunz, Michael, Nouri, Keyvan

“…No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to…”
Get full text

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction by Long, Yan, Tsai, Wen-Bin, Wangpaichitr, Medhi, Tsukamoto, Takashi, Savaraj, Niramol, Feun, Lynn G, Kuo, Macus Tien

“…Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the…”
Get full text

Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer by Nguyen, Dan J M, Theodoropoulos, George, Li, Ying-Ying, Wu, Chunjing, Sha, Wei, Feun, Lynn G, Lampidis, Theodore J, Savaraj, Niramol, Wangpaichitr, Medhi

“…Cisplatin resistance is a major barrier in the effective treatment of lung cancer. Cisplatin-resistant (CR) lung cancer cells do not primarily use glucose but…”
Get full text