Toll-like receptor-4 expression in infants with pertussis infection

Toll-like receptor-4 expression in infants with pertussis infection

Purpose Our aim was to evaluate the expression of Toll-like receptor-4 (TLR-4) and the level of interferon-gamma (IFN-γ) and interleukin-10 (IL-10) in young infants infected by Bordetella pertussis and B. parapertussis . Methods Twenty-two infants under the age of 3.5 months with the clinical suspic...

Full description

Saved in:
Bibliographic Details
Published in:Infection Vol. 41; no. 1; pp. 195 - 198
Main Authors: Vadasz, Z., Bamberger, E., Ben-Tikva, K., Feterman, M., Srugo, I., Kessel, A.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-02-2013
Springer Nature B.V
Subjects:
Bordetella parapertussis - genetics
Bordetella pertussis - genetics
Brief Report
Family Medicine
Female
General Practice
Humans
Infant
Infant, Newborn
Infants
Infectious Diseases
Interferon-gamma - blood
Internal Medicine
Laboratory tests
Male
Medicine
Medicine & Public Health
Monocytes - metabolism
Respiratory tract
Toll-Like Receptor 4 - blood
Toll-Like Receptor 4 - metabolism
Whooping Cough - blood
Whooping Cough - diagnosis
Whooping Cough - metabolism
Pertussis
Interferon-gamma
Toll-like receptor-4
Interleukin-10
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Our aim was to evaluate the expression of Toll-like receptor-4 (TLR-4) and the level of interferon-gamma (IFN-γ) and interleukin-10 (IL-10) in young infants infected by Bordetella pertussis and B. parapertussis . Methods Twenty-two infants under the age of 3.5 months with the clinical suspicion of pertussis were enrolled in the study. Nasopharyngeal secretions were obtained for laboratory testing, and blood samples were obtained for flow cytometry and cytokine level analysis. Results Six infants had positive PCR results for pertussis; the other 16 infants had infections attributable to another causal agent and were used as the control group. The mean fluorescence index, used as a measure of TLR-4 expression by monocytes, was significantly lower in infants with pertussis than in the control group infants (34.32 ± 18.58 vs. 63.14 ± 28, respectively; p  = 0.041). The serum IFN-γ level was also significantly lower in infants with pertussis than in the control group patients (0.41 ± 0.58 vs. 1.36 ± 1.87, respectively; p  = 0.04). No differences were found in the levels of IL-10. Conclusions Based on these results, we suggest that TL4 expression by monocytes and serum INF-γ levels are lower in infants with positive PCR results for pertussis than in infants with a non-pertussis upper respiratory tract infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-012-0288-8