Search Results - "Fesko, Kateryna"

Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions by Fesko, Kateryna

“…Most of biochemical and mutagenesis studies performed with L-threonine aldolases were done with respect to natural activity, the cleavage of L-threonine and…”
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Biocatalytic Methods for CC Bond Formation by Fesko, Kateryna, Gruber-Khadjawi, Mandana

“…Carbon‐carbon bond formation is among the most challenging transformations in the organic synthetic chemistry. Enzymes capable to perform this reaction are of…”
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Threonine aldolases: perspectives in engineering and screening the enzymes with enhanced substrate and stereo specificities by Fesko, Kateryna

“…Threonine aldolases have emerged as a powerful tool for asymmetric carbon-carbon bond formation. These enzymes catalyse the unnatural aldol condensation of…”
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Threonine aldolases—an emerging tool for organic synthesis by Steinreiber, Johannes, Fesko, Kateryna, Reisinger, Christoph, Schürmann, Martin, van Assema, Friso, Wolberg, Michael, Mink, Daniel, Griengl, Herfried

“…In a systematic study, 21 ring-substituted benzaldehydes were reacted with glycine under catalysis with a l-threonine aldolase ( lTA) from Pseudomonas putida…”
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Overcoming Thermodynamic and Kinetic Limitations of Aldolase-Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations by Steinreiber, Johannes, Schürmann, Martin, Wolberg, Michael, van Assema, Friso, Reisinger, Christoph, Fesko, Kateryna, Mink, Daniel, Griengl, Herfried

“…Dynamic and successful: The asymmetric synthesis of 2‐amino‐1‐phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes…”
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Editorial: PLP-Dependent Enzymes: Extraordinary Versatile Catalysts and Ideal Biotechnological Tools for the Production of Unnatural Amino Acids and Related Compounds by Di Salvo, Martino L, Fesko, Kateryna, Phillips, Robert S, Contestabile, Roberto

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Biocatalytic Methods for CC Bond Formation by Fesko, Kateryna, Gruber-Khadjawi, Mandana

“…Carbon-carbon bond formation is among the most challenging transformations in the organic synthetic chemistry. Enzymes capable to perform this reaction are of…”
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Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiary α-amino acids by Fesko, Kateryna, Strohmeier, Gernot A, Breinbauer, Rolf

“…The direct biochemical synthesis of tertiary α-amino acids with a wide range of diversity was recently reported using natural threonine aldolases LTA from…”
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Bioinformatic analysis of the fold type I PLP‐dependent enzymes reveals determinants of reaction specificity in l‐threonine aldolase from Aeromonas jandaei by Fesko, Kateryna, Suplatov, Dmitry, Švedas, Vytas

“…Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern…”
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Biocatalytic Access to α,α-Dialkyl-α-amino Acids by a Mechanism-Based Approach by Fesko, Kateryna, Uhl, Michael, Steinreiber, Johannes, Gruber, Karl, Griengl, Herfried

“…New donors—new products: Threonine aldolases (L‐TA, D‐TA) have now been found to accept donors other than glycine. In a simple asymmetric biocatalytic aldol…”
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Application of Threonine Aldolases for the Asymmetric Synthesis of α‐Quaternary α‐Amino Acids by Blesl, Julia, Trobe, Melanie, Anderl, Felix, Breinbauer, Rolf, Strohmeier, Gernot A., Fesko, Kateryna

“…We report the synthesis of diverse β‐hydroxy‐α,α‐dialkyl‐α‐amino acids with perfect stereoselectivity for the α‐quaternary center through the action of l‐ and…”
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Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiary [alpha]-amino acids by Fesko, Kateryna, Strohmeier, Gernot A, Breinbauer, Rolf

“…The direct biochemical synthesis of tertiary [alpha]-amino acids with a wide range of diversity was recently reported using natural threonine aldolases LTA…”
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Investigation of one-enzyme systems in the ω-transaminase-catalyzed synthesis of chiral amines by Fesko, Kateryna, Steiner, Kerstin, Breinbauer, Rolf, Schwab, Helmut, Schürmann, Martin, Strohmeier, Gernot A.

“…•(S)- and (R)-aromatic amines were synthesized using ω-transaminases.•Good to excellent conversions and e.e.-values of the amine products were…”
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Synthesis of β-hydroxy-α-amino acids with a reengineered alanine racemase by Fesko, Kateryna, Giger, Lars, Hilvert, Donald

“…The Y265A mutant of alanine racemase catalyzes the stereoselective condensation of glycine or alanine with a range of aromatic aldehydes. The Y265A mutant of…”
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Exploring the new threonine aldolases with broad donor specificity by Lypetska (Fesko), Kateryna, Strohmeier, Gernot, Breinbauer, Rolf

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Synthesis of γ-halogenated and long-chain β-hydroxy-α-amino acids and 2-amino-1,3-diols using threonine aldolases by Steinreiber, Johannes, Fesko, Kateryna, Mayer, Clemens, Reisinger, Christoph, Schürmann, Martin, Griengl, Herfried

“…The l- and d-threonine aldolase catalyzed formation of γ-halogenated and long-chain l- and d-3-alkylserine-derivatives 1– 12, respectively, was shown starting…”
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Four types of threonine aldolases: Similarities and differences in kinetics/thermodynamics by Fesko, Kateryna, Reisinger, Christoph, Steinreiber, Johannes, Weber, Hansjörg, Schürmann, Martin, Griengl, Herfried

“…Four types of threonine aldolases (TAs) with different stereospecificities were tested on the aldol synthesis of phenylserine (PS) starting from benzaldehyde…”
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efficient plasmid vector for expression cloning of large numbers of PCR fragments in Escherichia coli by Reisinger, Christoph, Kern, Alexander, Fesko, Kateryna, Schwab, Helmut

“…The described plasmid pEamTA was designed for parallel polymerase chain reaction (PCR) cloning of open reading frames (ORFs) in Escherichia coli. It relies on…”
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Synthesis of Aromatic 1,2-Amino Alcohols Utilizing a Bienzymatic Dynamic Kinetic Asymmetric Transformation by Steinreiber, Johannes, Schürmann, Martin, van Assema, Friso, Wolberg, Michael, Fesko, Kateryna, Reisinger, Christoph, Mink, Daniel, Griengl, Herfried

“…The applicability of the recent published bienzymatic protocol for the synthesis of (R)‐2‐amino‐1‐phenylethanol was tested using L‐threonine aldolase from…”
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Biocatalytic Access to α,α-Dialkyl-α-amino Acids by a Mechanism-Based Approach by Fesko, Kateryna, Uhl, Michael, Steinreiber, Johannes, Gruber, Karl, Griengl, Herfried

“…Neue Donoren – neue Produkte: Threonin‐Aldolasen (L‐TA, D‐TA) akzeptieren auch andere Donoren als Glycin. In einer einfachen asymmetrischen biokatalytischen…”
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