Effects of depression and excess body weight on cognition and functioning in young adults: A population-based study

Effects of depression and excess body weight on cognition and functioning in young adults: A population-based study

•The cognitive impairment was greater in the depression with excess body weight comorbidity group.•Functional impairment is also greater in subjects with depression and excess body weight comorbidity.•Also, depression interacted significantly with excess weight to reveal greater impairment in the co...

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Published in:Journal of affective disorders Vol. 282; pp. 401 - 406
Main Authors: Vieira, Igor Soares, Ferrugem, Sílvia Contreira Rodrigues, Reyes, Amanda Neumann, Branco, Jerônimo Costa, Mondin, Thaíse Campos, Cardoso, Taiane de Azevedo, Kapczinski, Flávio, Souza, Luciano Dias de Mattos, Jansen, Karen, da Silva, Ricardo Azevedo, Pedrotti Moreira, Fernanda
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-03-2021
Subjects:
Body mass index
Body Weight
Cognition
Cross-Sectional Studies
Depression
Depression - epidemiology
Functioning
Humans
Overweight
Psychiatric Status Rating Scales
Young Adult
Body mass index
Depression
Cognition
Overweight
Functioning
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Summary:•The cognitive impairment was greater in the depression with excess body weight comorbidity group.•Functional impairment is also greater in subjects with depression and excess body weight comorbidity.•Also, depression interacted significantly with excess weight to reveal greater impairment in the cognition and functioning of the individual. The purpose of this study is to assess the independent effects of depression and excess body weight (EBW) on cognition and functioning in a community sample of young adults. This was a cross-sectional of 943 young adults. The diagnosis of a current depressive episode was performed using the Mini International Neuropsychiatric Interview (MINI). Cognition and functioning were assessed using the Montreal Cognitive Assessment (MoCA) and the Functional Assessment Short Test (FAST), respectively. The EBW was defined as BMI ≥ 25.0 kg/m2. The independent main effects of depression and EBW, as well as the analysis interaction were performed using two-way analysis of covariance (ANCOVA). The total sample comprised 943 adults, with 75 (8.0%) individuals diagnosed with a current depressive episode and 493 (52,6%) with EBW. Of the 75 subjects with depression, 40 were identified with EBW comorbidity. Subjects with depression and EBW comorbidity reported greater cognitive and functional impairment, as compared to individuals with depression without EBW. There was a significant interaction between depression and EBW on MoCA total (p<0.001) as well as FAST total (p=0.010), work (p=0.002), cognition (p=0.023), finances (p=0.032) and relationships domains (p=0.008). The adverse effects of depression and EBW are independent and cumulative with respect to cognition and functioning of individuals. The understanding of the complex interactions between cognition, functioning, EBW and depression are important for development of preventive and therapeutic strategies.
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ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2020.12.083