Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they c...

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Bibliographic Details
Published in:Frontiers in aging neuroscience Vol. 10; p. 16
Main Authors: Cascella, Marco, Bimonte, Sabrina, Barbieri, Antonio, Del Vecchio, Vitale, Muzio, Maria Rosaria, Vitale, Andrea, Benincasa, Giulio, Ferriello, Anna Bella, Azzariti, Amalia, Arra, Claudio, Cuomo, Arturo
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 09-02-2018
Frontiers Media S.A
Subjects:
Alzheimer's disease
Animal cognition
Brain research
Cancer
Cognitive ability
Dementia
Fatty acids
Functional foods & nutraceuticals
Hippocampus
Inflammation
Ischemia
Memory
natural compounds
Neurodegeneration
Neurodegenerative diseases
Neuroprotection
Neuroprotective agents
Neuroscience
Neurosciences
Nigella sativa
Oxidative stress
Pathogenesis
Roles
thymoquinone
Tumor necrosis factor-TNF
Italy
thymoquinone
natural compounds
Nigella sativa
Alzheimer's disease
oxidative stress
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Summary:Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they could represent effective neuroprotective agents. The purpose of this manuscript is to analyze and to recapitulate the results of and studies on the potential role of NS/TQ in AD's prevention and treatment. The level of evidence for each included animal study has been assessed by using a modified CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) 10-item checklist. We used MEDLINE and EMBASE databases to screen relevant articles published up to July 2017. A manual search was also performed. The database search yielded 38 studies, of which 18 were included in this manuscript. Results from these approaches suggest that NS or TQ could represent an effective strategy against AD due to the balancing of oxidative processes and the binding to specific intracellular targets. The overall effects mainly regard the prevention of hippocampal pyramidal cell loss and the increased cognitive functions.
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Reviewed by: Jordi Olloquequi, Universidad Autónoma de Chile, Chile; Daniel Ortuño-Sahagún, University of Guadalajara, Mexico
These authors have contributed equally to this work.
Edited by: Antonio Camins, University of Barcelona, Spain
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2018.00016