Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension

The antihypertensive effect of crude stevioside obtained from the leaves of Stevia rebaudiana (Bertoni) Bertoni (Compositae) on previously untreated mild hypertensive patients was examined. Patients with essential hypertension were submitted to a placebo phase for 4 weeks. The volunteers selected in...

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Bibliographic Details
Published in:	Phytotherapy research Vol. 20; no. 9; pp. 732 - 736
Main Authors:	Ferri, Letícia A. F., Alves-Do-Prado, Wilson, Yamada, Sergio S., Gazola, Sebastião, Batista, Marcia R., Bazotte, Roberto B.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-09-2006 Wiley
Subjects:	Adult Antihypertensive Agents - analysis Antihypertensive Agents - therapeutic use Biological and medical sciences blood pressure clinical trial Diterpenes, Kaurane - adverse effects Diterpenes, Kaurane - therapeutic use Double-Blind Method Female General pharmacology Glucosides - adverse effects Glucosides - therapeutic use Humans Hypertension - drug therapy Male Medical sciences Middle Aged Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy placebo effect Prospective Studies Stevia - adverse effects Stevia - chemistry Stevia rebaudiana (Bertoni) Bertoni stevioside Human Hypertension Pharmacognosy Oral administration Cardiovascular disease Stevioside Compositae Medicinal plant placebo effect Dicotyledones Angiospermae Plant origin Stevia rebaudiana (Bertoni) Bertoni Antihypertensive agent Clinical trial Arterial pressure Spermatophyta Blood pressure Stevia rebaudiana Hemodynamics
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Summary:	The antihypertensive effect of crude stevioside obtained from the leaves of Stevia rebaudiana (Bertoni) Bertoni (Compositae) on previously untreated mild hypertensive patients was examined. Patients with essential hypertension were submitted to a placebo phase for 4 weeks. The volunteers selected in this phase were randomly assigned to receive either capsules containing placebo during 24 weeks or crude stevioside 3.75 mg/kg/day (7 weeks), 7.5 mg/kg/day (11 weeks) and 15.0 mg/kg/day (6 weeks). All capsules were prescribed twice a daily (b.i.d.), i.e. before lunch and before dinner. After the placebo phase and after each dose of crude stevioside, body mass index, electrocardiogram and laboratory tests were performed. During the investigation blood pressure (BP) was measured biweekly and the remaining data were collected at the end of each stevioside dose step. All adverse events were prospectively recorded but no major adverse clinical effects were observed during the trial. Systolic and diastolic BP decreased (p < 0.05) during the treatment with crude stevioside, but a similar effect was observed in the placebo group. Therefore, crude stevioside up to 15.0 mg/kg/day did not show an antihypertensive effect. Moreover, the results suggest that oral crude stevioside is safe and supports the well‐established tolerability during long term use as a sweetener in Brazil. Copyright © 2006 John Wiley & Sons, Ltd.
Bibliography:	ark:/67375/WNG-5FWGNWMP-T Brazilian Government CNPq - No. 400075/2002-0 ArticleID:PTR1944 istex:9AF54BA427DCB68CF77446AA4970487ED9DF1FB9
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1944