Search Results - "Ferrer Gago, Fernando J"

Functionalized Resins for the Synthesis of Peptide Alcohols by Ferrer‐Gago, Fernando J., Koh, Li Quan, Lane, David P.

“…Peptide alcohols are clinically important compounds that are underexplored in structure–activity relationship (SAR) studies in drug discovery. One reason for…”
Get full text

Methods and Approaches for the Solid‐Phase Synthesis of Peptide Alcohols by Ferrer‐Gago, Fernando J., Koh, Li Quan

“…Many methods have been developed for attaching an alcohol functionality to a solid support. However, not all of these methods are used to obtain peptide…”
Get full text

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles by Yuen, Tsz Ying, Brown, Christopher J, Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J, Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W, Verma, Chandra S, Lane, David P, Johannes, Charles W

“…All-hydrocarbon, i , i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged as promising new leads for cancer therapy. Typical chemical…”
Get full text

Synthesis of C‐terminal glycine‐rich o‐aminoanilide peptides without overacylation for use in benzotriazole‐mediated native chemical ligation by Ferrer‐Gago, Fernando J., Koh, Li Quan

“…Native chemical ligation (NCL) requires the constant development of methods that facilitate the efficient synthesis of C‐terminal peptide thioesters, which are…”
Get full text

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits by Ng, Simon, Juang, Yu-Chi, Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Ferrer-Gago, Fernando J, Lee, Xue’Er Cheryl, Liew, Xi, Johannes, Charles W, Brown, Christopher J, Kannan, Srinivasaraghavan, Aronica, Pietro G, Berglund, Nils A, Verma, Chandra S, Liu, Lijuan, Stoeck, Alexander, Sawyer, Tomi K, Partridge, Anthony W, Lane, David P

“…Nonspecific promiscuous compounds can mislead researchers and waste significant resources. This phenomenon, though well-documented for small molecules, has not…”
Get full text

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma by Johansson, Patrik, Krona, Cecilia, Kundu, Soumi, Doroszko, Milena, Baskaran, Sathishkumar, Schmidt, Linnéa, Vinel, Claire, Almstedt, Elin, Elgendy, Ramy, Elfineh, Ludmila, Gallant, Caroline, Lundsten, Sara, Ferrer Gago, Fernando J., Hakkarainen, Aleksi, Sipilä, Petra, Häggblad, Maria, Martens, Ulf, Lundgren, Bo, Frigault, Melanie M., Lane, David P., Swartling, Fredrik J., Uhrbom, Lene, Nestor, Marika, Marino, Silvia, Nelander, Sven

“…Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the…”
Get full text

NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay by Peier, Andrea, Ge, Lan, Boyer, Nicolas, Frost, John, Duggal, Ruchia, Biswas, Kaustav, Edmondson, Scott, Hermes, Jeffrey D, Yan, Lin, Zimprich, Chad, Sadruddin, Ahmad, Kristal Kaan, Hung Yi, Chandramohan, Arun, Brown, Christopher J, Thean, Dawn, Lee, Xue Er, Yuen, Tsz Ying, Ferrer-Gago, Fernando J, Johannes, Charles W, Lane, David P, Sherborne, Brad, Corona, Cesear, Robers, Matthew B, Sawyer, Tomi K, Partridge, Anthony W

“…Macrocyclic peptides open new opportunities to target intracellular protein–protein interactions (PPIs) that are often considered nondruggable by traditional…”
Get full text

Macrocyclization of an all- d linear α-helical peptide imparts cellular permeability by Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.

“…Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of…”
Get full text

Cover Feature: Functionalized Resins for the Synthesis of Peptide Alcohols (Chem. Eur. J. 2/2020) by Ferrer‐Gago, Fernando J., Koh, Li Quan, Lane, David P.

“…The resin's beads (in the column) are a polymer, such as polystyrene (PS) or polyethylene glycol (PEG), that can be functionalized with several linkers (e.g.,…”
Get full text

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01456j by Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W.

“…Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate E / Z ratios and access saturated analogues…”
Get full text

Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h by Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.

“…Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Peptide-based molecules hold great…”
Get full text

Macrocyclization of an all- linear α-helical peptide imparts cellular permeability by Kannan, Srinivasaraghavan, Aronica, Pietro G. A, Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J, Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J, Johannes, Charles W, Henry, Brian, Lane, David P, Sawyer, Tomi K, Verma, Chandra S, Partridge, Anthony W

“…Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein-protein interactions (PPIs). Indeed, the vast diversity of…”
Get full text