Search Results - "Ferrer, Manel"

A prospective, international, bicentric study to evaluate PremiCron suture material for cardiac valve surgery - PREMIVALVE a cohort study by Rufa, Magdalena, Ursulescu, Adrian, Baumann, Petra, Ferrer, Manel T

“…The most common age-related heart valve diseases include aortic valve stenosis and mitral valve insufficiency. The suture material is not the focus of most…”
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Revascularization and outcomes in ischaemic left ventricular dysfunction after heart failure admission: The RevascHeart study by Moliner-Abós, Carlos, Calvo-Barceló, Maria, Solé-Gonzalez, Eduard, Borrellas Martín, Andrea, Fluvià-Brugués, Paula, Sánchez-Vega, Jesús, Vime-Jubany, Joan, Vallverdú, Maria Ferré, Taurón Ferrer, Manel, Tobias-Castillo, Pablo E, de la Fuente Mancera, Juan Carlos, Vilardell-Rigau, Pau, Vila-Olives, Rosa, Diez-López, Carles, Bayés-Genís, Antoni, Arzamendi Aizpurua, Dabit, Ferreira-Gonzalez, Ignacio, Mirabet Pérez, Sònia

“…Despite numerous trials on revascularization in patients with heart failure (HF) and ischaemic left ventricular (LV) dysfunction, its role remains unsettled…”
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Optilene, a new non-absorbable monofilament is safe and effective for CABG anastomosis. OPTICABG - A prospective international, multi-centric, cohort study by Ursulescu, Adrian, Baumann, Petra, Ferrer, Manel Tauron, Contino, Monica, Romagnoni, Claudia, Antona, Carlo, Padró Fernández, Josep Maria

“…Coronary artery bypass grafting (CABG) is performed to improve quality of life and to reduce cardiac-related mortality and morbidity in patients with coronary…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence times by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Eastwood, Paul R., Esteve, Cristina, Ferrer, Manel, Forns, Pilar, Gómez, Elena, González, Jacob, Lozoya, Estrella, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere

“…The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for…”
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Severe community-acquired pneumonia: Characteristics and prognostic factors in ventilated and non-ventilated patients by Ferrer, Miquel, Travierso, Chiara, Cilloniz, Catia, Gabarrus, Albert, Ranzani, Otavio T, Polverino, Eva, Liapikou, Adamantia, Blasi, Francesco, Torres, Antoni

“…Patients with severe community-acquired pneumonia (SCAP) and life-threatening acute respiratory failure may require invasive mechanical ventilation (IMV)…”
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A modular synthesis of novel 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones as PDE4 inhibitors by Ferrer, Manel, Roberts, Richard S., Sevilla, Sara

“…A versatile, modular synthetic route to a series of 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones has been developed. These compounds represent a novel…”
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4‑Amino-7,8-dihydro-1,6-naphthyridin-5(6H)‑ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure–Activity Relationships by Roberts, Richard S, Sevilla, Sara, Ferrer, Manel, Taltavull, Joan, Hernández, Begoña, Segarra, Victor, Gràcia, Jordi, Lehner, Martin D, Gavaldà, Amadeu, Andrés, Miriam, Cabedo, Judit, Vilella, Dolors, Eichhorn, Peter, Calama, Elena, Carcasona, Carla, Miralpeix, Montserrat

“…Rational design of a novel template of naphthyridinones rapidly led to PDE4 inhibitors with subnanomolar enzymatic potencies. X-ray crystallography confirmed…”
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Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure–Activity Relationships by Gràcia, Jordi, Buil, Maria Antonia, Castro, Jordi, Eichhorn, Peter, Ferrer, Manel, Gavaldà, Amadeu, Hernández, Begoña, Segarra, Victor, Lehner, Martin D, Moreno, Imma, Pagès, Lluís, Roberts, Richard S, Serrat, Jordi, Sevilla, Sara, Taltavull, Joan, Andrés, Miriam, Cabedo, Judit, Vilella, Dolors, Calama, Elena, Carcasona, Carla, Miralpeix, Montserrat

“…Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists by Andrés, Miriam, Buil, Maria Antonia, Calbet, Marta, Casado, Oscar, Castro, Jordi, Eastwood, Paul R., Eichhorn, Peter, Ferrer, Manel, Forns, Pilar, Moreno, Imma, Petit, Silvia, Roberts, Richard S.

“…Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed…”
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Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists by Buil, Maria Antonia, Calbet, Marta, Castillo, Marcos, Castro, Jordi, Esteve, Cristina, Ferrer, Manel, Forns, Pilar, González, Jacob, López, Sara, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere

“…Monocyclic and bicyclic ring systems were investigated as the “core” section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists…”
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2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists by Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castillo, Marcos, Castro, Jordi, Eichhorn, Peter, Ferrer, Manel, Lehner, Martin D., Moreno, Imma, Roberts, Richard S., Sevilla, Sara

“…In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimization by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Calbet, Marta, Eastwood, Paul R., Eichhorn, Peter, Esteve, Cristina, Ferrer, Manel, Gómez, Elena, González, Jacob, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere, Zanuy, Miriam

“…Extensive structure–activity relationship (SAR) and structure–kinetic relationship (SKR) studies in the bicyclic heteroaromatic series of CRTh2 antagonists led…”
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2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists by Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Domènech, Teresa, Eichhorn, Peter, Ferrer, Manel, Gómez, Elena, Lehner, Martin D., Moreno, Imma, Roberts, Richard S., Sevilla, Sara

“…High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR…”
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Severe Combined Right Ventricular and Respiratory Failure. Treatment Options With Mechanical Assist Devices by Koller, Tobias, Miralles Bagán, Jordi, Durán-Cambra, Albert, Mirabet Pérez, Sonia, Tauron Ferrer, Manel, Galán Serrano, Josefina

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Disfunción ventricular derecha acompañada de insuficiencia respiratoria grave. Opciones terapéuticas con dispositivos de asistencia mecánica by Koller, Tobias, Miralles Bagán, Jordi, Durán-Cambra, Albert, Mirabet Pérez, Sonia, Tauron Ferrer, Manel, Galán Serrano, Josefina

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Solid-phase syntheses of N-substituted carbamates. Reaction monitoring by gel-phase 13C NMR using a 13C enriched BAL-linker by Fernández-Forner, Dolors, Huerta, Josep M, Ferrer, Manel, Casals, Gaspar, Ryder, Hamish, Giralt, Ernest, Albericio, Fernando

“…The solid-phase synthesis of N-substituted carbamates using the tris(alkoxy)benzyl (BAL) resin is reported. The incorporation of the primary amine was carried…”
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