Search Results - "Ferrell, James E. Jr"

Mechanisms of specificity in protein phosphorylation by Ubersax, Jeffrey A, Ferrell Jr, James E

“…A typical protein kinase must recognize between one and a few hundred bona fide phosphorylation sites in a background of approximately 700,000 potentially…”
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Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle by Chang, Jeremy B., Ferrell Jr, James E.

“…In an in vitro Xenopus extract system that can undergo cell cycles, mitosis spreads through the cytoplasm in ‘trigger waves’ of Cdk1 activation, which may…”
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Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops by Tsai, Tony Yu-Chen, Choi, Yoon Sup, Ma, Wenzhe, Pomerening, Joseph R, Tang, Chao, Ferrell, James E. Jr

“…A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators…”
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Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions by Brandman, Onn, Ferrell, James E, Li, Rong, Meyer, Tobias

“…Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we…”
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Bistability, Bifurcations, and Waddington's Epigenetic Landscape by Ferrell, James E.

“…Waddington's epigenetic landscape is probably the most famous and most powerful metaphor in developmental biology. Cells, represented by balls, roll downhill…”
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Ultrafast distant wound response is essential for whole-body regeneration by Fan, Yuhang, Chai, Chew, Li, Pengyang, Zou, Xinzhi, Ferrell, Jr, James E, Wang, Bo

“…Injury induces systemic responses, but their functions remain elusive. Mechanisms that can rapidly synchronize wound responses through long distances are also…”
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Modeling the Cell Cycle: Why Do Certain Circuits Oscillate? by Ferrell, James E., Tsai, Tony Yu-Chen, Yang, Qiong

“…Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why…”
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The Cdk1–APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch by Yang, Qiong, Ferrell, James E.

“…Frog embryonic cell cycles are driven by oscillations in the activity of cyclin B–Cdk1. This complex activates the E3 ligase APC/C Cdc20 , which in turn causes…”
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A Mechanism for the Evolution of Phosphorylation Sites by Pearlman, Samuel M., Serber, Zach, Ferrell, James E.

“…Protein phosphorylation provides a mechanism for the rapid, reversible control of protein function. Phosphorylation adds negative charge to amino acid side…”
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Identification and Comparative Analysis of Multiple Mammalian Speedy/Ringo Proteins by Cheng, Aiyang, Xiong, Wen, Ferrell, Jr, James E., Solomon, Mark J.

“…In addition to their activation via binding to cyclins, cyclin-dependent kinases (CDKs)can be activated via binding to a novel cell cycle regulator termed…”
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Stepwise oxidations play key roles in the structural and functional regulations of DJ-1 by Song, In-Kang, Kim, Mi-Sun, Ferrell, Jr, James E, Shin, Dong-Hae, Lee, Kong-Joo

“…DJ-1 is known to play neuroprotective roles by eliminating reactive oxygen species (ROS) as an antioxidant protein. However, the molecular mechanism of DJ-1…”
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Robust trigger wave speed in Xenopus cytoplasmic extracts by Huang, Jo-Hsi, Chen, Yuping, Huang, William Y. C., Tabatabaee, Saman, Ferrell, James E.

“…Self-regenerating trigger waves can spread rapidly through the crowded cytoplasm without diminishing in amplitude or speed, providing consistent, reliable,…”
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The nucleus serves as the pacemaker for the cell cycle by Afanzar, Oshri, Buss, Garrison K, Stearns, Tim, Ferrell, Jr, James E

“…Mitosis is a dramatic process that affects all parts of the cell. It is driven by an oscillator whose various components are localized in the nucleus,…”
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Detection of Multistability, Bifurcations, and Hysteresis in a Large Class of Biological Positive-Feedback Systems by Angeli, David, Ferrell, James E., Sontag, Eduardo D., Lebowitz, Joel L.

“…It is becoming increasingly clear that bistability (or, more generally, multistability) is an important recurring theme in cell signaling. Bistability may be…”
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Xenopus laevis Egg Extract Preparation and Live Imaging Methods for Visualizing Dynamic Cytoplasmic Organization by Cheng, Xianrui, Ferrell, Jr, James E

“…Traditionally used for bulk biochemical assays, Xenopus laevis egg extracts have emerged as a powerful imaging-based tool for studying cytoplasmic phenomena,…”
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Spatial Positive Feedback at the Onset of Mitosis by Santos, Silvia D.M., Wollman, Roy, Meyer, Tobias, Ferrell, James E.

“…Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus. Positive feedback loops regulate the…”
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Desynchronizing Embryonic Cell Division Waves Reveals the Robustness of Xenopus laevis Development by Anderson, Graham A., Gelens, Lendert, Baker, Julie C., Ferrell, James E.

“…The early Xenopus laevis embryo is replete with dynamic spatial waves. One such wave, the cell division wave, emerges from the collective cell division timing…”
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Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos by Tsai, Tony Y-C, Theriot, Julie A, Ferrell, Jr, James E

“…During the early development of Xenopus laevis embryos, the first mitotic cell cycle is long (∼85 min) and the subsequent 11 cycles are short (∼30 min) and…”
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The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation by Lockhead, Sarah, Moskaleva, Alisa, Kamenz, Julia, Chen, Yuxin, Kang, Minjung, Reddy, Anay R., Santos, Silvia D.M., Ferrell, James E.

“…Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before…”
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Emi2 at the Crossroads: Where CSF Meets MPF by Hansen, David V., Pomerening, Joseph R., Summers, Matthew K., Miller, Julie J., Ferrell, Jr, James E., Jackson, Peter K.

“…Vertebrate eggs arrest at metaphase of meiosis II due to an activity known as cytostatic factor (CSF). CSF antagonizes the ubiquitin ligase activity of the…”
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