Search Results - "Ferrell, J. E."

Thresholds and ultrasensitivity from negative cooperativity by Ha, S. H., Ferrell, J. E.

“…Negative cooperativity is a phenomenon in which the binding of one or more molecules of a ligand to a multimeric receptor makes it more difficult for…”
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Ultrasensitivity in the Mitogen-Activated Protein Kinase Cascade by Huang, Chi-Ying F., Ferrell, James E.

“…The mitogen-activated protein kinase (MAPK) cascade is a highly conserved series of three protein kinases implicated in diverse biological processes. Here we…”
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The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes by Ferrell, James E., Machleder, Eric M.

“…Xenopus oocytes convert a continuously variable stimulus, the concentration of the maturation-inducing hormone progesterone, into an all-or-none biological…”
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The Protein Kinase p90 Rsk as an Essential Mediator of Cytostatic Factor Activity by Bhatt, Ramesh R., Ferrell, James E.

“…Persistent activation of p42 mitogen-activated protein kinase (p42 MAPK) during mitosis induces a "cytostatic factor" arrest, the arrest responsible for…”
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The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes by Bagowski, C P, Myers, J W, Ferrell, Jr, J E

“…The induction of Xenopus laevis oocyte maturation by progesterone is a striking example of a steroid hormone-mediated event that does not require…”
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Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs by Ferrell, James E.

“…Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade…”
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How responses get more switch-like as you move down a protein kinase cascade by Ferrell, James E.

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B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts by YUE, J, XIONG, W, FERRELL, J. E

“…During mitosis, a select pool of MEK1 and p42/p44 MAPK becomes activated at the kinetochores and spindle poles, without substantial activation of the bulk of…”
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Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs by FERRELL, J. E, WU, M, GERHART, J. C, MARTIN, G. S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Xenopus oocyte maturation: new lessons from a good egg by Ferrell Jr, James E.

“…Fully grown Xenopus oocytes can remain in their immature state essentially indefinitely, or, in response to the steroid hormone progesterone, can be induced to…”
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Multisite Phosphorylation and the Countdown to S Phase by Deshaies, Raymond J., Ferrell, James E.

“…Remarkably, SCF Cdc4 ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates (Nash et al., 2001). This numerical wizardry…”
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Requirement for MAPK Activation for Normal Mitotic Progression in Xenopus Egg Extracts by Guadagno, Thomas M., Ferrell, James E.

“…The p42 mitogen-activated protein kinase (MAPK) is required for progression through meiotic M phase in Xenopus oocytes. This report examines whether it also…”
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Tyrosine-Specific Protein Phosphorylation is Regulated by Glycoprotein IIb-IIIa in Platelets by Ferrell, James E., Martin, G. Steven

“…We have previously shown that a number of platelet proteins become phosphorylated at tyrosine residues in response to platelet-activating agents. Here we…”
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Mechanistic Studies of the Dual Phosphorylation of Mitogen-activated Protein Kinase by Ferrell, James E., Bhatt, Ramesh R.

“…Previous work on the responses of mitogen-activated protein (MAP) kinase cascade components in aXenopus oocyte extract system demonstrated that p42 MAP kinase…”
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MAP kinases in mitogenesis and development by Ferrell, Jr, J E

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Platelet tyrosine-specific protein phosphorylation is regulated by thrombin by FERRELL, J. E. JR, MARTIN, G. S

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A Role for Mitogen-Activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells by Wang, Xiao Min, Zhai, Ye, Ferrell, James E.

“…The spindle assembly checkpoint prevents cells whose spindles are defective or chromosomes are misaligned from initiating anaphase and leaving mitosis. Studies…”
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How regulated protein translocation can produce switch-like responses by Ferrell, James E.

“…It is widely appreciated that the regulated translocation of signaling proteins can increase the specificity and speed of signal transduction. It is less…”
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Evidence that Inactive p42 Mitogen-Activated Protein Kinase and Inactive Rsk Exist as a Heterodimer in vivo by Hsiao, Kuang-Ming, Chou, Szu-Yi, Shih, Shian-Jiun, Ferrell, James E.

“…Mitogen-activated protein kinases (MAP kinases) are active only when phosphorylated. Here we examine whether the activation of Xenopus p42 MAP kinase might…”
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Dependence of Mos‐induced Cdc2 activation on MAP kinase function in a cell‐free system by Huang, C. Y., Ferrell, J. E.

“…The progression of G2‐arrested Xenopus laevis oocytes into meiotic M‐phase is accompanied by the nearly simultaneous activation of p42 MAP kinase and…”
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