Search Results - "Ferreirinha, Fátima"

β3 Adrenoceptor‐induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release by Silva, Isabel, Magalhães‐Cardoso, M. Teresa, Ferreirinha, Fátima, Moreira, Sílvia, Costa, Ana Filipa, Silva, Diogo, Vieira, Cátia, Silva‐Ramos, Miguel, Correia‐de‐Sá, Paulo

“…Background and Purpose The mechanism by which β3 receptor agonists (e.g. mirabegron) control bladder overactivity may involve adenosine release from human and…”
Get full text

Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension by Bessa-Gonçalves, Mafalda, Bragança, Bruno, Martins-Dias, Eduardo, Vinhas, Adriana, Certal, Mariana, Rodrigues, Tânia, Ferreirinha, Fátima, Costa, Maria Adelina, Correia-de-Sá, Paulo, Fontes-Sousa, Ana Patrícia

“…Sustained pressure overload and fibrosis of the right ventricle (RV) are the leading causes of mortality in pulmonary arterial hypertension (PAH). Although the…”
Get full text

Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation by Pinheiro, Ana Rita, Paramos-de-Carvalho, Diogo, Certal, Mariana, Costa, Cristina, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Costa, Maria Adelina, Correia-de-Sá, Paulo

“…Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve…”
Get full text

Histamine Induces ATP Release from Human Subcutaneous Fibroblasts, via Pannexin-1 Hemichannels, Leading to Ca2+ Mobilization and Cell Proliferation by Pinheiro, Ana Rita, Paramos-de-Carvalho, Diogo, Certal, Mariana, Costa, Maria Adelina, Costa, Cristina, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Sévigny, Jean, Correia-de-Sá, Paulo

“…Changes in the regulation of connective tissue ATP-mediated mechano-transduction and remodeling may be an important link to the pathogenesis of chronic pain…”
Get full text

Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22 by Guerra Leal, Bárbara, Barros-Barbosa, Aurora, Ferreirinha, Fátima, Chaves, João, Rangel, Rui, Santos, Agostinho, Carvalho, Cláudia, Martins-Ferreira, Ricardo, Samões, Raquel, Freitas, Joel, Lopes, João, Ramalheira, João, Lobo, Maria Graça, Martins da Silva, António, Costa, Paulo P., Correia-de-Sá, Paulo

“…Objective : ATP-gated ionotropic P2X7 receptors (P2X7R) actively participate in epilepsy and other neurological disorders. Neocortical nerve terminals of…”
Get full text

Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of post-menopausal women by Bessa-Andrês, Catarina, Pinto-Cardoso, Rui, Tarasova, Karyna, Pereira-Gonçalves, Ana Luísa, Gaio-Ferreira-Castro, Joana Maria, Carvalho, Liliana S, Costa, Maria Adelina, Ferreirinha, Fátima, Canadas-Sousa, Ana, Marinhas, José, Freitas, Rolando, Lemos, Rui, Vilaça, Adélio, Oliveira, António, Correia-de-Sá, Paulo, Noronha-Matos, José Bernardo

“…Mechanical stimulation (MS) significantly increases the release of adenine and uracil nucleotides from bone marrow-derived mesenchymal stem cells (BM-MSCs)…”
Get full text

ADP‐Induced Ca2+ Signaling and Proliferation of Rat Ventricular Myofibroblasts Depend on Phospholipase C‐Linked TRP Channels Activation Within Lipid Rafts by Certal, Mariana, Vinhas, Adriana, Barros‐Barbosa, Aurora, Ferreirinha, Fátima, Costa, Maria Adelina, Correia‐de‐Sá, Paulo

“…Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP…”
Get full text

A survey of spinocerebellar ataxia in South Brazil : 66 new cases with Machado-Joseph disease, SCA7, SCA8, or unidentified disease-causing mutations by JARDIM, Laura Bannach, SILVEIRA, Isabel, PEREIRA, Maria Luiza, FERRO, Anabela, ALONSO, Isabel, DO CEU MOREIRA, Maria, MENDONCA, Pedro, FERREIRINHA, Fatima, SEQUEIROS, Jorge, GIUGLIANI, Roberto

“…The autosomal dominant spinocerebellar ataxias (SCAs) are a clinical and genetically heterogeneous group of debilitating, neurodegenerative diseases, related…”
Get full text

Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors by Noronha-Matos, José Bernardo, Pinto-Cardoso, Rui, Bessa-Andrês, Catarina, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Costa, Maria Adelina, Marinhas, José, Freitas, Rolando, Lemos, Rui, Vilaça, Adélio, Oliveira, António, Pelletier, Julie, Sévigny, Jean, Correia-de-Sá, Paulo

“…Endogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells (BM-MSCs) through the…”
Get full text

Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus by Neiva, Rafael, Caulino-Rocha, Ana, Ferreirinha, Fátima, Lobo, Maria Graça, Correia-de-Sá, Paulo

“…Corticosteroids exert a dual role in eukaryotic cells through their action via (1) intracellular receptors (slow genomic responses), or (2) membrane-bound…”
Get full text

Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts by Certal, Mariana, Vinhas, Adriana, Pinheiro, Ana Rita, Ferreirinha, Fátima, Barros-Barbosa, Aurora Raquel, Silva, Isabel, Costa, Maria Adelina, Correia-de-Sá, Paulo

“…Graphical abstract…”
Get full text

P2X7‐induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow‐derived mesenchymal stem cells by Noronha‐Matos, José Bernardo, Coimbra, João, Sá‐e‐Sousa, Ana, Rocha, Rui, Marinhas, José, Freitas, Rolando, Guerra‐Gomes, Sónia, Ferreirinha, Fátima, Costa, Maria Adelina, Correia‐de‐Sá, Paulo

“…Polymorphisms of the P2X7 receptor have been associated with increased risk of fractures in postmenopausal women. Although both osteoblasts and osteoclasts…”
Get full text

The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy by Bragança, Bruno, Nogueira-Marques, Sílvia, Ferreirinha, Fátima, Fontes-Sousa, Ana Patrícia, Correia-de-Sá, Paulo

“…Background: Mounting evidence indicate that reducing the sinoatrial node (SAN) activity may be a useful therapeutic strategy to control of heart failure…”
Get full text

Up‐regulation of P2X7 receptor–mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex by Barros‐Barbosa, Aurora R., Fonseca, Ana L., Guerra‐Gomes, Sónia, Ferreirinha, Fátima, Santos, Agostinho, Rangel, Rui, Lobo, M. Graça, Correia‐de‐Sá, Paulo, Cordeiro, J. Miguel

“…Summary Objective Thirty percent of patients with epilepsy are refractory to medication. The majority of these patients have mesial temporal lobe epilepsy…”
Get full text

Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus by Vieira, Cátia, Ferreirinha, Fátima, Magalhães-Cardoso, Maria T, Silva, Isabel, Marques, Patrícia, Correia-de-Sá, Paulo

“…Uncoupling between ATP overflow and extracellular adenosine formation changes purinergic signaling in post-inflammatory ileitis. Adenosine neuromodulation…”
Get full text

Lack of endogenous adenosine tonus on sympathetic neurotransmission in spontaneously hypertensive rat mesenteric artery by Sousa, Joana Beatriz, Vieira-Rocha, Maria Sofia, Sá, Carlos, Ferreirinha, Fátima, Correia-de-Sá, Paulo, Fresco, Paula, Diniz, Carmen

“…Increased sympathetic activity has been implicated in hypertension. Adenosine has been shown to play a role in blood flow regulation. In the present study, the…”
Get full text

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers by Herman-de-Sousa, Carina, Pinheiro, Ana Rita, Paramos-de-Carvalho, Diogo, Costa, Maria Adelina, Ferreirinha, Fátima, Magalhães-Cardoso, Teresa, Ribeiro, Severino, Pelletier, Julie, Sévigny, Jean, Correia-de-Sá, Paulo

“…Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the…”
Get full text

Deficits in Endogenous Adenosine Formation by Ecto-5'-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis by Oliveira, Laura, Correia, Alexandra, Cristina Costa, Ana, Guerra-Gomes, Sónia, Ferreirinha, Fátima, Magalhães-Cardoso, Maria Teresa, Vilanova, Manuel, Correia-de-Sá, Paulo

“…AMP dephosphorylation via ecto-5′-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO,…”
Get full text

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis by Correia-de-Sá, Paulo, Pelletier, Julie, Dias, Ana Sofia, Silva, Isabel, Ferreirinha, Fátima, Magalhães-Cardoso, Maria Teresa, Vieira, Cátia, Sévigny, Jean

“…Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for…”
Get full text

A2A receptor-induced overexpression of pannexin-1 channels indirectly mediates adenosine fibrogenic actions by favouring ATP release from human subcutaneous fibroblasts by Herman-de-Sousa, Carina, Costa, Maria Adelina, Silva, Rafaela Pedro, Ferreirinha, Fátima, Ribeiro, Severino, Correia-de-Sá, Paulo

“…AIMSDisorganization of the subcutaneous tissue due to inflammation and fibrosis is a common feature in patients with myofascial pain. Dermal accumulation of…”
Get full text