Search Results - "Ferreira, Valerie"

Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy by Ferreira, Valerie, Twisk, Jaap, Kwikkers, Karin, Aronica, Eleonora, Brisson, Diane, Methot, Julie, Petry, Harald, Gaudet, Daniel

“…Cellular immune responses to adeno-associated viral (AAV) vectors used for gene therapy have been linked to attenuated transgene expression and loss of…”
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Clinical Considerations for Capsid Choice in the Development of Liver-Targeted AAV-Based Gene Transfer by Pipe, Steven, Leebeek, Frank W.G., Ferreira, Valerie, Sawyer, Eileen K., Pasi, John

“…As gene transfer with adeno-associated virus (AAV) vectors is starting to enter clinical practice, this review examines the impact of vector capsid choice in…”
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Cell-Based Tracers as Trojan Horses for Image-Guided Surgery by Sier, Vincent Q, de Vries, Margreet R, van der Vorst, Joost R, Vahrmeijer, Alexander L, van Kooten, Cornelis, Cruz, Luis J, de Geus-Oei, Lioe-Fee, Ferreira, Valerie, Sier, Cornelis F M, Alves, Frauke, Muthana, Munitta

“…Surgeons rely almost completely on their own vision and palpation to recognize affected tissues during surgery. Consequently, they are often unable to…”
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Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates by Salas, David, Kwikkers, Karin L., Zabaleta, Nerea, Bazo, Andrea, Petry, Harald, van Deventer, Sander J., Aseguinolaza, Gloria Gonzalez, Ferreira, Valerie

“…Adeno-associated virus (AAV)–based liver gene therapy has been shown to be clinically successful. However, the presence of circulating neutralizing antibodies…”
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Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5 ch and AAV1 by Majowicz, Anna, Salas, David, Zabaleta, Nerea, Rodríguez-Garcia, Estefania, González-Aseguinolaza, Gloria, Petry, Harald, Ferreira, Valerie

“…In the gene therapy field, re-administration of adeno-associated virus (AAV) is an important topic because a decrease in therapeutic protein expression might…”
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Enhanced Factor IX Activity following Administration of AAV5-R338L “Padua” Factor IX versus AAV5 WT Human Factor IX in NHPs by Spronck, Elisabeth A., Liu, Ying Poi, Lubelski, Jacek, Ehlert, Erich, Gielen, Sander, Montenegro-Miranda, Paula, de Haan, Martin, Nijmeijer, Bart, Ferreira, Valerie, Petry, Harald, van Deventer, Sander J.

“…Gene therapy for severe hemophilia B is advancing and offers sustained disease amelioration with a single treatment. We have reported the efficacy and safety…”
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Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis by van der Marel, Sander, Majowicz, Anna, Kwikkers, Karin, van Logtenstein, Richard, te Velde, Anje A, De Groot, Anne S, Meijer, Sybren L, van Deventer, Sander J, Petry, Harald, Hommes, Daniel W, Ferreira, Valerie

“…AIM：To explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of Tregitope 167 in an experimental colitis model.METHODS：The…”
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Teaching tolerance: New approaches to enzyme replacement therapy for Pompe disease by Cousens, Leslie P., Mingozzi, Federico, van der Marel, Sander, Su, Yan, Garman, Richard, Ferreira, Valerie, Martin, William, Scott, David W., De Groot, Anne S

“…Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human…”
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Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo by Majowicz, Anna, van der Marel, Sander, te Velde, Anje A, Meijer, Sybren L, Petry, Harald, van Deventer, Sander J, Ferreira, Valerie

“…Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg cells…”
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Nuclear Receptors Nur77, Nurr1, and NOR-1 Expressed in Atherosclerotic Lesion Macrophages Reduce Lipid Loading and Inflammatory Responses by Bonta, Peter I, van Tiel, Claudia M, Vos, Mariska, Pols, Thijs W.H, van Thienen, Johannes V, Ferreira, Valérie, Arkenbout, E Karin, Seppen, Jurgen, Spek, C Arnold, van der Poll, Tom, Pannekoek, Hans, de Vries, Carlie J.M

“…OBJECTIVE—Atherosclerosis is an inflammatory disease in which macrophage activation and lipid loading play a crucial role. In this study, we investigated…”
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Current use of benzodiazepines in anxiety disorders by Cloos, Jean-Marc, Ferreira, Valérie

“…PURPOSE OF REVIEWThe aim of this study is to provide a review of articles published between July 2007 and August 2008 on the current use and rationale of…”
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Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients by Gil-Farina, Irene, Fronza, Raffaele, Kaeppel, Christine, Lopez-Franco, Esperanza, Ferreira, Valerie, D'Avola, Delia, Benito, Alberto, Prieto, Jesus, Petry, Harald, Gonzalez-Aseguinolaza, Gloria, Schmidt, Manfred

“…Recombinant adeno-associated viral vectors (rAAV) currently constitute a real therapeutic strategy for the sustained correction of diverse genetic conditions…”
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VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis by Hawinkels, Lukas J.A.C, Zuidwijk, Kim, Verspaget, Hein W, de Jonge-Muller, Eveline S.M, Duijn, Wim van, Ferreira, Valérie, Fontijn, Ruud D, David, Guido, Hommes, Daniel W, Lamers, Cornelis B.H.W, Sier, Cornelis F.M

“…Abstract Angiogenesis is crucial for the progression of colorectal carcinomas in which the bioavailability of Vascular Endothelial Growth Factor (VEGF) plays a…”
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Gene and cell therapy based treatment strategies for inflammatory bowel diseases by van der Marel, Sander, Majowicz, Anna, van Deventer, Sander, Petry, Harald, Hommes, Daniel W, Ferreira, Valerie

“…Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young adults.Currently available therapies can result in…”
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701. Successful In Vivo Re-Administration of AAV with the Use of Two-Step AAV Injection by Majowicz, Anna, Petry, Harald, Ferreira, Valerie

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Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside by Ferreira, Valerie, Petry, Harald, Salmon, Florence

“…Alipogene tiparvovec (Glybera(®)) is an adeno-associated virus serotype 1 (AAV1)-based gene therapy that has been developed for the treatment of patients with…”
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Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs by Majowicz, Anna, Nijmeijer, Bart, Lampen, Margit H., Spronck, Lisa, de Haan, Martin, Petry, Harald, van Deventer, Sander J., Meyer, Christian, Tangelder, Marco, Ferreira, Valerie

“…Currently, individuals with pre-existing neutralizing antibodies (NABs) against adeno-associated virus (AAV) above titer of 5 are excluded from systemic…”
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Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial by Gaudet, D, Méthot, J, Déry, S, Brisson, D, Essiembre, C, Tremblay, G, Tremblay, K, de Wal, J, Twisk, J, van den Bulk, N, Sier-Ferreira, V, van Deventer, S

“…We describe the 2-year follow-up of an open-label trial (CT-AMT-011–01) of AAV1-LPL S447X gene therapy for lipoprotein lipase (LPL) deficiency (LPLD), an…”
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THU-365-Adeno-associated virus-serotype-specific transduction patterns in mice and non-human primates liver tissue: Implications for therapeutic efficacy by Majowicz, Anna, Schwarz, Lukas, Laat, Johannes de, Deventer, Sander van, Ferreira, Valerie

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele by Carmeliet, Peter, Ferreira, Valérie, Breier, Georg, Pollefeyt, Saskia, Kieckens, Lena, Gertsenstein, Marina, Fahrig, Michaela, Vandenhoeck, Ann, Harpal, Kendraprasad, Eberhardt, Carmen, Declercq, Cathérine, Pawling, Judy, Moons, Lieve, Collen, Désiré, Risau, Werner, Nagy, Andras

“…The endothelial cell-specific vascular endothelial growth factor (VEGF) and its cellular receptors Flt-1 and Flk-1 have been implicated in the formation of the…”
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