Search Results - "Ferreira, Natália Noronha"
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Ionic Cross-Linking as a Strategy to Modulate the Properties of Oral Mucoadhesive Microparticles Based on Polysaccharide Blends
Published in Pharmaceutics (19-03-2021)“…Polymer blends of gellan gum (GG)/retrograded starch(RS) and GG/pectin (P) were cross-linked with calcium, aluminum, or both to prepare mucoadhesive…”
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Modulating Fingolimod (FTY720) Anti-SARS-CoV‑2 Activity Using a PLGA-Based Drug Delivery System
Published in ACS applied bio materials (18-07-2022)“…COVID-19 has resulted in more than 490 million people being infected worldwide, with over 6 million deaths by April 05th, 2022. Even though the development of…”
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Computational and experimental approaches for chitosan-based nano PECs design: Insights on a deeper comprehension of nanostructure formation
Published in Carbohydrate polymers (15-02-2021)“…[Display omitted] •Chitosan-based nano PECs were rationally designed for methotrexate delivery.•pH effect on ionization degree of materials was estimated by…”
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Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review
Published in European journal of pharmaceutics and biopharmaceutics (01-08-2020)“…[Display omitted] Cancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die…”
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Design of mucoadhesive gellan gum and chitosan nanoparticles intended for colon-specific delivery of peptide drugs
Published in Colloids and surfaces. A, Physicochemical and engineering aspects (05-11-2021)“…Nanotechnology has been widely used in the development of polymer nanocarriers for the oral delivery of biomolecules. The use of nanostructured systems can…”
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Alginate-Based Delivery Systems for Bevacizumab Local Therapy: In Vitro Structural Features and Release Properties
Published in Journal of pharmaceutical sciences (01-04-2019)“…Alginate-based polyelectrolyte complexes (PECs) and hydrogel were engineered as platforms for local bevacizumab (BVZ) therapy. This study provides deep…”
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Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol
Published in Drug development and industrial pharmacy (01-02-2020)“…Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES). Their impact on drug release rates and…”
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Solid dispersions based on chitosan/hypromellose phthalate blends to modulate pharmaceutical properties of zidovudine
Published in Pharmaceutical development and technology (28-05-2022)“…Zidovudine (AZT) has been widely used alone or in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus. Its erratic…”
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Development and validation of a rapid RP-HPLC method for simultaneous quantification of paclitaxel and cetuximab in immunoliposomes
Published in Talanta (Oxford) (01-04-2021)“…The development of rational therapies against complex diseases, such as cancer, has increased in the past few years due to the advances of ‘omics’…”
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A novel pH-responsive hydrogel-based on calcium alginate engineered by the previous formation of polyelectrolyte complexes (PECs) intended to vaginal administration
Published in Drug development and industrial pharmacy (03-10-2017)“…This work aimed to develop a calcium alginate hydrogel as a pH responsive delivery system for polymyxin B (PMX) sustained-release through the vaginal route…”
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Rational design of nanocarriers based on gellan gum/retrograded starch exploiting polyelectrolyte complexation and ionic cross-linking processes: A potential technological platform for oral delivery of bevacizumab
Published in Journal of drug delivery science and technology (01-12-2021)“…The structural fragility of monoclonal antibodies (mAbs), such as bevacizumab (BVZ), is a critical parameter for oral administration and can limit the use of…”
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Gellan Gum/Pectin Beads Are Safe and Efficient for the Targeted Colonic Delivery of Resveratrol
Published in Polymers (08-01-2018)“…This work addresses the establishment and characterization of gellan gum:pectin (GG:P) biodegradable mucoadhesive beads intended for the colon-targeted…”
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Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy
Published in Frontiers in bioengineering and biotechnology (02-02-2023)“…Cell membrane-covered biomimetic nanosystems have allowed the development of homologous nanostructures to bestow nanoparticles with enhanced biointerfacing…”
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Multilayered polymer coating modulates mucoadhesive and biological properties of camptothecin-loaded lipid nanocapsules
Published in International journal of pharmaceutics (25-03-2023)“…[Display omitted] •High CPT loading in the nanocapsules was achieved.•Polymer coating provided mucoadhesiveness to nanocapsules.•Polymer coating modulated CPT…”
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A SARS-CoV-2 impedimetric biosensor based on the immobilization of ACE-2 receptor-containing entire cell membranes as the biorecognition element
Published in Talanta (Oxford) (01-02-2023)“…A SARS-CoV-2 biosensor based on the biorecognition of the spike protein to the angiotensin-converting enzyme 2 (ACE-2) transmembrane receptor was developed…”
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Humic Substances: Possibility of New Therapeutic Application
Published in Revista Brasileira Multidisciplinar (01-12-2015)“…Humic substances (HS) are heterogeneous molecular aggregates, which have no defined structure and constitute the principal fraction of natural organic matter…”
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