Search Results - "Ferreira, Leonardo L."

Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach by de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Ferreira, Rafaela S, Espinoza Chávez, Rocio Marisol, Ferreira, Leonardo L. G, Slafer, Brian W, Magalhães, Luma G, Krogh, Renata, Oliva, Glaucius, Cruz, Fabio Cardoso, Dias, Luiz Carlos, Andricopulo, Adriano D

“…A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor…”
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Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani by Ortega, Humberto E, Ferreira, Leonardo L G, Melo, Weilan G P, Oliveira, Ana Ligia L, Ramos Alvarenga, René F, Lopes, Norberto P, Bugni, Tim S, Andricopulo, Adriano D, Pupo, Mônica T

“…Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan…”
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H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies by Xavier, Rogério P, Mengarda, Ana C, Silva, Marcos P, Roquini, Daniel B, Salvadori, Maria C, Teixeira, Fernanda S, Pinto, Pedro L, Morais, Thiago R, Ferreira, Leonardo L G, Andricopulo, Adriano D, de Moraes, Josué

“…Schistosomiasis is a socioeconomically devastating parasitic infection afflicting hundreds of millions of people and animals worldwide. It is the most…”
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Neglected Tropical Diseases: A Chemoinformatics Approach for the Use of Biodiversity in Anti-Trypanosomatid Drug Discovery by Valli, Marilia, Döring, Thiago H, Marx, Edgard, Ferreira, Leonardo L G, Medina-Franco, José L, Andricopulo, Adriano D

“…The development of new treatments for neglected tropical diseases (NTDs) remains a major challenge in the 21st century. In most cases, the available drugs are…”
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2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling by Ferreira, Rafael Augusto Alves, Junior, Celso de Oliveira Rezende, Martinez, Pablo David Grigol, Koovits, Paul John, Soares, Bruna Miranda, Ferreira, Leonardo L G, Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D, Galuppo, Mariana K, Uliana, Silvia R B, Matheeussen, An, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz Carlos

“…Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this…”
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Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies by Machado, Valkiria, Cenci, Arthur R, Teixeira, Kerolain F, Sens, Larissa, Tizziani, Tiago, Nunes, Ricardo J, Ferreira, Leonardo L. G, Yunes, Rosendo A, Sandjo, Louis P, Andricopulo, Adriano D, de Oliveira, Aldo S

“…Alzheimer's disease (AD) is a neurodegenerative disease that is characterized as the main dementia in the elderly. Eighteen pyrazolines were synthesized and…”
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Hierarchical Clustering and Target-Independent QSAR for Antileishmanial Oxazole and Oxadiazole Derivatives by Teles, Henrique R., Ferreira, Leonardo L. G., Valli, Marilia, Coelho, Fernando, Andricopulo, Adriano D.

“…Leishmaniasis is a neglected tropical disease that kills more than 20,000 people each year. The chemotherapy available for the treatment of the disease is…”
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ADMET modeling approaches in drug discovery by Ferreira, Leonardo L.G., Andricopulo, Adriano D.

“…•ADMET modeling plays a pivotal part in drug discovery.•Chemoinformatics has evolved into robust machine learning approaches.•Comprehensive web-based platforms…”
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Editorial: Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design, Volume II by Ferreira, Leonardo L. G., Andricopulo, Adriano D.

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Susceptibility of Angiostrongylus cantonensis Larvae to Anthelmintic Drugs by Roquini, Daniel B., Silva, Gabriel L., Ferreira, Leonardo L. G., Andricopulo, Adriano D., Wilairatana, Polrat, De Moraes, Josué

“…Human helminthiasis affects approximately one in five people in the world and disproportionally affects the poorest and most deprived communities. Human…”
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Chemoinformatics Strategies for Leishmaniasis Drug Discovery by Ferreira, Leonardo L G, Andricopulo, Adriano D

“…Leishmaniasis is a fatal neglected tropical disease (NTD) that is caused by more than 20 species of parasites. The disease kills approximately 20,000 people…”
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Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents by Koovits, Paul J, Dessoy, Marco A, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G, Chelucci, Rafael C, Michelan-Duarte, Simone, Andricopulo, Adriano D, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz C

“…A series of benzene sulphonamides with good potency and selectivity against Leishmania spp. intracellular amastigotes was identified by high-throughput…”
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Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors by Araujo, Sheila C, Maltarollo, Vinicius G, Almeida, Michell O, Ferreira, Leonardo L G, Andricopulo, Adriano D, Honorio, Kathia M

“…Activin-like kinase 5 (ALK-5) is involved in the physiopathology of several conditions, such as pancreatic carcinoma, cervical cancer and liver hepatoma…”
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Quantitative Structure-Activity Relationships for Structurally Diverse Chemotypes Having Anti- Trypanosoma cruzi Activity by de Souza, Anacleto S, Ferreira, Leonardo L G, de Oliveira, Aldo S, Andricopulo, Adriano D

“…Small-molecule compounds that have promising activity against macromolecular targets from occasionally fail when tested in whole-cell phenotypic assays. This…”
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Editorial: Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design by Ferreira, Leonardo L G, Andricopulo, Adriano D

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Approaches to advance drug discovery for neglected tropical diseases by Ferreira, Leonardo L.G., de Moraes, Josué, Andricopulo, Adriano D.

“…•The R&D pipeline for NTDs has been filled with promising preclinical and clinical candidates.•Leishmaniasis drug discovery programs have led to several novel…”
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Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol by de Oliveira, Aldo S., Llanes, Luana C., Nunes, Ricardo J., Nucci-Martins, Catharina, de Souza, Anacleto S., Palomino-Salcedo, David L., Dávila-Rodríguez, María J., Ferreira, Leonardo L. G., Santos, Adair R. S., Andricopulo, Adriano D.

“…The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported…”
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Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics by Pauli, Ivani, Rezende, Jr, Celso de O, Slafer, Brian W, Dessoy, Marco A, de Souza, Mariana L, Ferreira, Leonardo L G, Adjanohun, Abraham L M, Ferreira, Rafaela S, Magalhães, Luma G, Krogh, Renata, Michelan-Duarte, Simone, Del Pintor, Ricardo Vaz, da Silva, Fernando B R, Cruz, Fabio C, Dias, Luiz C, Andricopulo, Adriano D

“…Cruzain, the main cysteine protease of , plays key roles in all stages of the parasite's life cycle, including nutrition acquisition, differentiation, evasion…”
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Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors by Medeiros, Alex R, Ferreira, Leonardo L G, de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Espinoza-Chávez, Rocío Marisol, Dias, Luiz Carlos, Andricopulo, Adriano D

“…Natural products based on imidazole scaffolds have inspired the discovery of a wide variety of bioactive compounds. Herein, a series of imidazoles that act as…”
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Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti- Trypanosoma cruzi Activity by Ferreira, Rafael A A, Pauli, Ivani, Sampaio, Thiago S, de Souza, Mariana L, Ferreira, Leonardo L G, Magalhães, Luma G, Rezende, Jr, Celso de O, Ferreira, Rafaela S, Krogh, Renata, Dias, Luiz C, Andricopulo, Adriano D

“…Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective…”
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