Search Results - "Ferreira, Leonardo"

HLA-G: At the Interface of Maternal–Fetal Tolerance by Ferreira, Leonardo M.R, Meissner, Torsten B, Tilburgs, Tamara, Strominger, Jack L

“…During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine mucosa without being rejected by the maternal immune system. Several…”
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Next-generation regulatory T cell therapy by Ferreira, Leonardo M. R., Muller, Yannick D., Bluestone, Jeffrey A., Tang, Qizhi

“…Regulatory T cells (T reg cells) are a small subset of immune cells that are dedicated to curbing excessive immune activation and maintaining immune…”
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ADMET modeling approaches in drug discovery by Ferreira, Leonardo L.G., Andricopulo, Adriano D.

“…•ADMET modeling plays a pivotal part in drug discovery.•Chemoinformatics has evolved into robust machine learning approaches.•Comprehensive web-based platforms…”
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Molecular docking and structure-based drug design strategies by Ferreira, Leonardo G, Dos Santos, Ricardo N, Oliva, Glaucius, Andricopulo, Adriano D

“…Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex…”
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Regulation of NADPH oxidases in skeletal muscle by Ferreira, Leonardo F., Laitano, Orlando

“…The only known function of NAD(P)H oxidases is to produce reactive oxygen species (ROS). Skeletal muscles express three isoforms of NAD(P)H oxidases (Nox1,…”
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Cancer metabolism: The Warburg effect today by Ferreira, Leonardo M.R.

“…One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells…”
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Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9 by Mandal, Pankaj K., Ferreira, Leonardo M.R., Collins, Ryan, Meissner, Torsten B., Boutwell, Christian L., Friesen, Max, Vrbanac, Vladimir, Garrison, Brian S., Stortchevoi, Alexei, Bryder, David, Musunuru, Kiran, Brand, Harrison, Tager, Andrew M., Allen, Todd M., Talkowski, Michael E., Rossi, Derrick J., Cowan, Chad A.

“…Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in…”
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Time series clustering via community detection in networks by Ferreira, Leonardo N., Zhao, Liang

“…In this paper, we propose a technique for time series clustering using community detection in complex networks. Firstly, we present a method to transform a set…”
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Approaches to advance drug discovery for neglected tropical diseases by Ferreira, Leonardo L.G., de Moraes, Josué, Andricopulo, Adriano D.

“…•The R&D pipeline for NTDs has been filled with promising preclinical and clinical candidates.•Leishmaniasis drug discovery programs have led to several novel…”
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Covid-19 and the cardiovascular system: a comprehensive review by Azevedo, Rafael Bellotti, Botelho, Bruna Gopp, Hollanda, João Victor Gonçalves de, Ferreira, Leonardo Villa Leão, Junqueira de Andrade, Letícia Zarur, Oei, Stephanie Si Min Lilienwald, Mello, Tomás de Souza, Muxfeldt, Elizabeth Silaid

“…Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the…”
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Generation of hypoimmunogenic human pluripotent stem cells by Han, Xiao, Wang, Mengning, Duan, Songwei, Franco, Paul J., Kenty, Jennifer Hyoje-Ryu, Hedrick, Preston, Xia, Yulei, Allen, Alana, Ferreira, Leonardo M. R., Strominger, Jack L., Melton, Douglas A., Meissner, Torsten B., Cowan, Chad A.

“…Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate immune surveillance impacts cell engraftment, yet a strategy to control…”
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis by Yu, Haojie, Rimbert, Antoine, Palmer, Alice E., Toyohara, Takafumi, Xia, Yulei, Xia, Fang, Ferreira, Leonardo M.R., Chen, Zhifen, Chen, Tao, Loaiza, Natalia, Horwitz, Nathaniel Brooks, Kacergis, Michael C., Zhao, Liping, Soukas, Alexander A., Kuivenhoven, Jan Albert, Kathiresan, Sekar, Cowan, Chad A.

“…Although human genetic studies have implicated many susceptible genes associated with plasma lipid levels, their physiological and molecular functions are not…”
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Conference report: Advanced Therapies Week 2023 by Ferreira, Leonardo Mr

“…The Advanced Therapies Week 2023 conference took place in Miami, FL, USA. Over the course of 4 days packed with talks, panels, company showcases and networking…”
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Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach by de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Ferreira, Rafaela S, Espinoza Chávez, Rocio Marisol, Ferreira, Leonardo L. G, Slafer, Brian W, Magalhães, Luma G, Krogh, Renata, Oliva, Glaucius, Cruz, Fabio Cardoso, Dias, Luiz Carlos, Andricopulo, Adriano D

“…A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor…”
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Kidney Stones: Treatment and Prevention by Fontenelle, Leonardo Ferreira, Sarti, Thiago Dias

“…Kidney stones are a common disorder, with an annual incidence of eight cases per 1,000 adults. During an episode of renal colic, the first priority is to rule…”
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COVID-19: Small-Molecule Clinical Trials Landscape by Ferreira, Leonardo L G, Andricopulo, Adriano D

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Drugs and vaccines in the 21st century for neglected diseases by Ferreira, Leonardo L G, Andricopulo, Adriano D

“…Fexinidazole entered clinical trials in 2009 and is currently being registered as a treatment for early-stage and late-stage human African trypanosomiasis…”
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Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics by Skartsis, Nikolaos, Muller, Yannick D., Ferreira, Leonardo M.R.

“…Novel biologics are currently being tested in clinical trials for the treatment of autoimmune diseases and the prevention of transplant allograft rejection…”
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Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani by Ortega, Humberto E, Ferreira, Leonardo L G, Melo, Weilan G P, Oliveira, Ana Ligia L, Ramos Alvarenga, René F, Lopes, Norberto P, Bugni, Tim S, Andricopulo, Adriano D, Pupo, Mônica T

“…Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan…”
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Mitochondrial basis for sex-differences in metabolism and exercise performance by Ferreira, Leonardo F

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