Search Results - "Ferreira, José Maria"

Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators by M F Gonçalves, Bruno, S P Cardoso, David, U Ferreira, Maria-José

“…Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the…”
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Molecular Docking Characterizes Substrate-Binding Sites and Efflux Modulation Mechanisms within P‑Glycoprotein by Ferreira, Ricardo J, Ferreira, Maria-José U, dos Santos, Daniel J. V. A

“…P-Glycoprotein (Pgp) is one of the best characterized ABC transporters, often involved in the multidrug-resistance phenotype overexpressed by several cancer…”
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BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer by Raimundo, Liliana, Paterna, Angela, Calheiros, Juliana, Ribeiro, Joana, Cardoso, David S. P., Piga, Ilaria, Neto, Susana Junqueira, Hegan, Denise, Glazer, Peter M., Indraccolo, Stefano, Mulhovo, Silva, Costa, José Luís, Ferreira, Maria‐José U., Saraiva, Lucília

“…Background and Purpose Advances in the treatment of triple‐negative breast and ovarian cancer remain challenging. In particular, resistance to the available…”
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Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells by Ramalhete, Cátia, Mulhovo, Silva, Lage, Hermann, Ferreira, Maria-José U

“…The collateral sensitivity effect is among the most promising strategies for overcoming multidrug resistance in cancer. In this work, 28 cucurbitane-type…”
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Natural products in drug discovery and human health by Ferreira, Maria-José U.

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Insights on P-Glycoprotein’s Efflux Mechanism Obtained by Molecular Dynamics Simulations by Ferreira, Ricardo J, Ferreira, Maria-José U, dos Santos, Daniel J. V. A

“…P-Glycoprotein (P-gp) is often involved in multidrug resistance (MDR) to the pharmacological action of a wide number of anticancer agents. In this article, a…”
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Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers by Ferreira, Ricardo J, Kincses, Annamária, Gajdács, Márió, Spengler, Gabriella, dos Santos, Daniel J. V. A, Molnár, Joseph, Ferreira, Maria-José U

“…The phytochemical study of Euphorbia pedroi led to the isolation of a new tetracyclic triterpenoid with an unusual spiro scaffold, spiropedroxodiol (1), along…”
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Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells by Sancha, Shirley A R, Szemerédi, Nikoletta, Spengler, Gabriella, Ferreira, Maria-José U

“…Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Aiming at generating a small library of anticancer compounds for overcoming MDR,…”
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Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells by Silva, Cristina Duarte, Ramalhete, Cátia, Spengler, Gabriella, Mulhovo, Silva, Molnar, Joseph, Ferreira, Maria-José U.

“…Aiming at overcoming multidrug resistance (MDR) in cancer, we have been studying Momordica balsamina, a vegetable known as African pumpkin. Five undescribed…”
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Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies by Ferreira, Ricardo J., Bonito, Cátia A., Cordeiro, M. Natália D. S., Ferreira, Maria-José U., dos Santos, Daniel J. V. A.

“…Efflux pumps of the ATP-binding cassette transporters superfamily (ABC transporters) are frequently involved in the multidrug-resistance (MDR) phenomenon in…”
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Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer by Ferreira, Ricardo J., Gajdács, Márió, Kincses, Annamária, Spengler, Gabriella, dos Santos, Daniel J.V.A., Ferreira, Maria-José U.

“…[Display omitted] Naringenin (1), isolated from Euphorbia pedroi, was previously derivatized yielding compounds 2–13. In this study, aiming at expanding the…”
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Monoterpene indole alkaloids as leads for targeting multidrug resistant cancer cells from the African medicinal plant Tabernaemontana elegans by Ferreira, Maria-José U., Paterna, Angela

“…Multidrug resistance (MDR) is the main challenge in cancer treatment. Several mechanisms of MDR have been proposed, such as an increased drug efflux due to the…”
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Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells by Cardoso, David S.P., Kincses, Annamária, Nové, Márta, Spengler, Gabriella, Mulhovo, Silva, Aires-de-Sousa, João, dos Santos, Daniel J.V.A., Ferreira, Maria-José U.

“…Aiming at generating a series of monoterpene indole alkaloids with enhanced multidrug resistance (MDR) reversing activity in cancer, two major epimeric…”
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Reversal of P-glycoprotein-mediated multidrug resistance by natural N-alkylated indole alkaloid derivatives in KB-ChR-8-5 drug-resistant cancer cells by Bharathiraja, Pradhapsingh, Cardoso, David S P, Rajendra Prasad, N, Mulhovo, Silva, Lakra, Deepa S, Ferreira, Maria-José U

“…Multidrug resistance (MDR) remains a significant challenge in cancer chemotherapy due to the overexpression of ATP-binding cassette drug-efflux transporters,…”
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Vobasinyl–Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells by Paterna, Angela, Gomes, Sofia E, Borralho, Pedro M, Mulhovo, Silva, Rodrigues, Cecília M. P, Ferreira, Maria-José U

“…Phytochemical investigation of the roots of the African medicinal plant Tabernaemontana elegans led to the isolation of three new (1–3) and two known (4 and 5)…”
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Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance by Ramalhete, Cátia, Mulhovo, Silva, Molnar, Joseph, Ferreira, Maria-José U.

“…[Display omitted] •Thirty natural and semi-synthetic triterpenoids were evaluated as ABCB1 modulators.•Most of the natural compounds displayed strong MDR…”
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Monoterpene indole alkaloid azine derivatives as MDR reversal agents by Paterna, Angela, Khonkarn, Ruttiros, Mulhovo, Silva, Moreno, Alexis, Madeira Girio, Patricia, Baubichon-Cortay, Hélène, Falson, Pierre, Ferreira, Maria-José U.

“…[Display omitted] •Twenty-four indole alkaloid derivatives were evaluated as MDR reversers.•Compounds bearing an aromatic azine moiety showed the best anti-MDR…”
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Jatrophane diterpenes and cancer multidrug resistance – ABCB1 efflux modulation and selective cell death induction by Reis, Mariana Alves, Ahmed, Omar Bauomy, Spengler, Gabriella, Molnár, Joseph, Lage, Hermann, Ferreira, Maria-José U

“…Modulation of P-glycoprotein (ABCB1) and evaluation of the collateral sensitivity effect are among the most promising approaches to overcome multidrug…”
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Exploring Jolkinol D Derivatives To Overcome Multidrug Resistance in Cancer by Reis, Mariana A, Ahmed, Omar B, Spengler, Gabriella, Molnár, Joseph, Lage, Hermann, Ferreira, Maria-José U

“…Macrocyclic monoacyl lathyrane derivatives bearing a benzoyl moiety were previously found to be strong ABCB1 modulators. To explore the effects of different…”
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Lycorine and homolycorine derivatives for chemo-sensitizing resistant human ovarian adenocarcinoma cells by Sancha, Shirley A.R., Dobiasová, Simona, Nejedlý, Tomáš, Strnad, Ondřej, Viktorová, Jitka, Ferreira, Maria-José U.

“…•A set of lycorine and homolycorine-type e alkaloid derivatives was prepared.•Compounds were evaluated as MDR reversers in resistant breast and ovarian cancer…”
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