Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state

In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB i...

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Bibliographic Details
Published in:	Brazilian journal of microbiology Vol. 53; no. 2; pp. 795 - 799
Main Authors:	Barcelos Valiatti, Tiago, Silva Carvalho, Tatiane, Fernandes Santos, Fernanda, Silva Nodari, Carolina, Cayô, Rodrigo, da Silva, Juliana Thalita Paulino, da Silva, Cicileia Correia, Ferreira, Jacqueline Andrade, Moura, Lorena Brandhuber, dos Santos, Levy Assis, Gales, Ana Cristina
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-06-2022 Springer Nature B.V
Subjects:	Acinetobacter baumannii - genetics Acinetobacter Infections - epidemiology Acinetobacter Infections - microbiology Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Proteins - genetics beta-Lactamases - genetics Biomedical and Life Sciences Carbapenems Clinical Microbiology - Short Communication Clone Cells Drug Resistance, Multiple, Bacterial - genetics Epidemiology Food Microbiology Humans Life Sciences Medical Microbiology Microbial Ecology Microbial Genetics and Genomics Microbial Sensitivity Tests Microbiology Minocycline Multidrug resistance Multidrug resistant organisms Mycology Overcrowding Phenotypes Polymyxins Carbapenemase Northern region spp Non-fermenter bacilli International clones Acinetobacter spp
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Summary:	In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried bla OXA-23 and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1517-8382 1678-4405
DOI:	10.1007/s42770-022-00706-4