Search Results - "Ferreira, Ildete L."

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors by Mota, Sandra I., Ferreira, Ildete L., Rego, A. Cristina

“…Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take…”
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Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease by Carvalho da Silva, António M, Lemos, Cristina, Silva, Henrique B, Ferreira, Ildete L, Tomé, Angelo R, Rego, A Cristina, Cunha, Rodrigo A

“…Alzheimer's disease (AD) is characterized by progressive memory deficits accompanied by synaptic and metabolic deficits, namely of mitochondrial function. AD…”
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Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures by Mota, Sandra I, Ferreira, Ildete L, Pereira, Claudia, Oliveira, Catarina R, Rego, A Cristina

“…Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder among the elderly. Nmethyl- D-aspartate receptor (NMDAR) overactivation has…”
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Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease by Toledo, Juan P, Fernández-Pérez, Eduardo J, Ferreira, Ildete L, Marinho, Daniela, Riffo-Lepe, Nicolas O, Pineda-Cuevas, Benjamin N, Pinochet-Pino, Luis F, Burgos, Carlos F, Rego, A Cristina, Aguayo, Luis G

“…Alzheimer's disease (AD) is the most common cause of senile dementia worldwide, characterized by both cognitive and behavioral deficits. Amyloid beta peptide…”
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Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Blood Mononuclear Cells by Ferreira, Ildete L, Costa, Solange, Moraes, Bruno J, Costa, Ana, Fokt, Olga, Marinho, Daniela, Alves, Vera, Baptista, Isabel P, Rego, A Cristina

“…Periodontitis (PDT) and type 2 diabetes (T2D) have demonstrated a bidirectional relationship and imbalanced oxidative stress linked to mitochondrial…”
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Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado–Joseph Disease by Almeida, Filipa, Ferreira, Ildete L., Naia, Luana, Marinho, Daniela, Vilaça-Ferreira, Ana Catarina, Costa, Marta D., Duarte-Silva, Sara, Maciel, Patrícia, Rego, A. Cristina

“…Mitochondrial dysfunction has been described in many neurodegenerative disorders; however, there is less information regarding mitochondrial deficits in…”
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Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model by Ferreiro, Elisabete, Lanzillo, Mariagrazia, Canhoto, Diogo, Carvalho da Silva, António M., Mota, Sandra I., Dias, Inês S., Ferreira, Ildete L., Fontes, Ana R., Mastrella, Giorgia, Pinheiro, Paulo, Valero, Jorge, Rego, A. Cristina

“…During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's…”
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Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells by Ribeiro, Márcio, Rosenstock, Tatiana R., Cunha-Oliveira, Teresa, Ferreira, Ildete L., Oliveira, Catarina R., Rego, A. Cristina

“…Huntington’s disease (HD) is a CAG repeat disorder affecting the HD gene, which encodes for huntingtin (Htt) and is characterized by prominent cell death in…”
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Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N‐methyl‐D‐aspartate receptor in mature hippocampal cultures treated with amyloid‐β oligomers by Costa, Rui O., Lacor, Pascale N., Ferreira, Ildete L., Resende, Rosa, Auberson, Yves P., Klein, William L., Oliveira, Catarina R., Rego, Ana C., Pereira, Cláudia M. F.

“…Summary Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density…”
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OXPHOS dysfunction regulates integrin- beta 1 modifications and enhances cell motility and migration by Nunes, Joana B, Peixoto, Joana, Soares, Paula, Maximo, Valdemar, Carvalho, Sandra, Pinho, Salome S, Vieira, Andre F, Paredes, Joana, Rego, Ana C, Ferreira, Ildete L, Gomez-Lazaro, Maria, Sobrinho-Simoes, Manuel, Singh, Keshav K, Lima, Jorge

“…Mitochondria are central organelles for cellular metabolism. In cancer cells, mitochondrial oxidative phosphorylation (OXPHOS) dysfunction has been shown to…”
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Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease by Silva, Ana C., Ferreira, Ildete L., Hayden, Michael R., Ferreiro, Elisabete, Rego, A. Cristina

“…Huntington's disease (HD) is caused by an expansion of CAG repeats in the HTT gene, leading to expression of mutant huntingtin (mHTT) and selective striatal…”
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Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus — Linking NMDA receptors and the reelin pathway by Mota, Sandra I., Ferreira, Ildete L., Valero, Jorge, Ferreiro, Elisabete, Carvalho, Ana L., Oliveira, Catarina R., Rego, A. Cristina

“…Early cognitive deficits in Alzheimer's disease (AD) have been related to deregulation of N-methyl-d-aspartate receptors (NMDARs) and synaptic dysfunction in…”
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Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease by Mota, Sandra I., Costa, Rui O., Ferreira, Ildete L., Santana, Isabel, Caldeira, Gladys L., Padovano, Carmela, Fonseca, Ana C., Baldeiras, Inês, Cunha, Catarina, Letra, Liliana, Oliveira, Catarina R., Pereira, Cláudia M.F., Rego, Ana Cristina

“…Oxidative stress and endoplasmic reticulum (ER) stress have been associated with Alzheimer's disease (AD) progression. In this study we analyzed whether…”
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Mitochondrial-dependent apoptosis in Huntington's disease human cybrids by Ferreira, Ildete L., Nascimento, Maria V., Ribeiro, Márcio, Almeida, Sandra, Cardoso, Sandra M., Grazina, Manuela, Pratas, João, Santos, Maria João, Januário, Cristina, Oliveira, Catarina R., Rego, A. Cristina

“…We investigated the involvement of mitochondrial-dependent apoptosis in Huntington's disease (HD) vs. control (CTR) cybrids, obtained from the fusion of human…”
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Northeast Portuguese propolis protects against staurosporine and hydrogen peroxide-induced neurotoxicity in primary cortical neurons by Cardoso, Susana M., Ribeiro, Márcio, Ferreira, Ildete L., Cristina Rego, A.

“…► The Northeast Portuguese propolis phenolic extract is neuroprotective. ► The propolis phenolic extract decreases H2O2-stimulated increment of ROS production…”
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Mitochondrial Dysfunction and Decreased Cytochrome Ic/I in Cell and Animal Models of Machado–Joseph Disease by Almeida, Filipa, Ferreira, Ildete L, Naia, Luana, Marinho, Daniela, Vilaça-Ferreira, Ana Catarina, Costa, Marta D, Duarte-Silva, Sara, Maciel, Patrícia, Rego, A. Cristina

“…Mitochondrial dysfunction has been described in many neurodegenerative disorders; however, there is less information regarding mitochondrial deficits in…”
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Chemical ischemia' in cultured retina cells: the role of excitatory amino acid receptors and of energy levels on cell death by Ferreira, Ildete L, Duarte, Carlos B, Carvalho, Arsélio P

“…In this study, we determined whether the retina cell death observed in response to an ischemic-like insult is related to an overactivation of the ionotropic…”
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Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-[beta] oligomers by Costa, Rui O, Lacor, Pascale N, Ferreira, Ildete L, Resende, Rosa, Auberson, Yves P, Klein, William L, Oliveira, Catarina R, Rego, Ana C, Pereira, Cláudia M. F

“…Summary Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density…”
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Mitochondrial-dependent apoptosis in Huntington' s disease human cybrids by Ferreira, Ildete L, Nascimento, Maria V, Ribeiro, Marcio, Almeida, Sandra, Cardoso, Sandra M, Grazina, Manuela, Pratas, Joao, Santos, Maria Joao, Januario, Cristina, Oliveira, Catarina R, Rego, ACristina

“…We investigated the involvement of mitochondrial-dependent apoptosis in Huntington's disease (HD) vs. control (CTR) cybrids, obtained from the fusion of human…”
Get full text

OXPHOS dysfunction regulates integrin-β1 modifications and enhances cell motility and migration by Nunes, Joana B, Peixoto, Joana, Soares, Paula, Maximo, Valdemar, Carvalho, Sandra, Pinho, Salome S, Vieira, Andre F, Paredes, Joana, Rego, Ana C, Ferreira, Ildete L, Gomez-Lazaro, Maria, Sobrinho-Simoes, Manuel, Singh, Keshav K, Lima, Jorge

“…Mitochondria are central organelles for cellular metabolism. In cancer cells, mitochondrial oxidative phosphorylation (OXPHOS) dysfunction has been shown to…”
Get full text