Highly sensitive voltammetric determination of hydrochlorothiazide using a glassy carbon electrode modified with Super P carbon black nanoparticles

Hydrochlorothiazide is an extremely important diuretic that regulates body functions, which can prevent several diseases. However, the abuse of this diuretic is concerning since it does not require a medical prescription, particularly for aesthetic purposes such as weight loss, which can lead to var...

Full description

Saved in:

Bibliographic Details
Published in:	Analytical methods Vol. 16; no. 36; p. 6271
Main Authors:	Santos-Neto, Domingos R, Lopes, Carlos E C, Silva, Gabrielly P, Castro, Lizandra N, Silva, João Pedro C, Ferreira, Dianderson C M, Silva, Luiz Ricardo G, Dantas, Luiza M F, da Silva, Iranaldo S
Format:	Journal Article
Language:	English
Published:	England 19-09-2024
Subjects:	Carbon - chemistry Diuretics - analysis Diuretics - chemistry Diuretics - urine Electrochemical Techniques - instrumentation Electrochemical Techniques - methods Electrodes Hydrochlorothiazide - analysis Hydrochlorothiazide - chemistry Hydrochlorothiazide - urine Limit of Detection Nanoparticles - chemistry Soot - chemistry Tablets
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Hydrochlorothiazide is an extremely important diuretic that regulates body functions, which can prevent several diseases. However, the abuse of this diuretic is concerning since it does not require a medical prescription, particularly for aesthetic purposes such as weight loss, which can lead to various health problems, including ventricular arrhythmia. The present work aims to use a glassy carbon electrode modified with Super P carbon black (SPCB/GCE) to quantify hydrochlorothiazide through Linear Sweep Adsorptive Stripping Voltammetry (LSAdSV). The modification of the GCE with SPCB significantly improved the response of hydrochlorothiazide. Furthermore, due to the adsorptive nature of charge transport, applying preconcentration time enhanced sensitivity. The optimized system provided a linear range of 0.5 to 30.0 μmol L with a detection limit of 0.083 μmol L . Pharmaceutical tablet analyses indicated approximately 25 mg per tablet, which was confirmed by the UV-vis and in agreement with that indicated by the manufacturer. Furthermore, analyses of the tea, synthetic urine, tap water and lake water samples indicated recovery values close to 100%, demonstrating that there was no matrix effect. Therefore, it is possible to infer that the proposed method together with the sensor modified with carbon black nanoparticles presented excellent results, demonstrating that it can be an alternative method of monitoring this drug in different samples.
ISSN:	1759-9679
DOI:	10.1039/d4ay00900b