Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis

Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis

Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats...

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Bibliographic Details
Published in:BioMed research international Vol. 2017; no. 2017; pp. 1 - 7
Main Authors: Pereira, E. C., da Silva, Nicácio Henrique, Santos, N. P. S., Santos, K. R. P., Martins, Monica C. B., Aguiar, G. M., Ferreira, D. K. S., Silva, T. D. S., Marinho, K. S. N., Silva, C. R., Aguiar Júnior, F. C. A.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Acids
Animals
Ascomycota - chemistry
Benzofurans - administration & dosage
Benzofurans - chemistry
Body Weight - drug effects
Cladonia substellata
Dibenzofurans
Drug dosages
Female
Females
Fetal Development - drug effects
Fetus - drug effects
Fetuses
Health aspects
Laboratories
Male
Natural products
Organ Size - drug effects
Organogenesis - drug effects
Pregnancy
Rats
Rodents
Studies
Teratogenesis - drug effects
Teratogenic agents
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Summary:Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy. After 20 days the fetuses were removed and analyzed. A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed. Morphological changes in the litter were visualized as exposure of the eye and atrophy of the limbs at the dose of 25 mg/kg. Histological analysis of the liver of the fetus showed reduction in the number of megakaryocytes between experimental groups and increase in the number of hepatocytes in a dose of 25 mg/kg. The experimental model used in this study reveals teratogenic effect of usnic acid in the period of organogenesis. Since this achievement, the importance of evaluating the toxic effects of natural substances is imperative, in order to elucidate the care in their indication as drug.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Paul M. Tulkens
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/5948936