Search Results - "Ferre, Elise M.N."

Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance by Fujikado, Noriyuki, Mann, Alexander O., Bansal, Kushagra, Romito, Kimberly R., Ferre, Elise M.N., Rosenzweig, Sergio D., Lionakis, Michail S., Benoist, Christophe, Mathis, Diane

“…Aire’s primary mechanism of action is to regulate transcription of a battery of genes in medullary thymic epithelial cells (mTECs) and, consequently, negative…”
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Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome by Besnard, Marine, Sérazin, Céline, Ossart, Jason, Moreau, Anne, Vimond, Nadège, Flippe, Léa, Sein, Hanna, Smith, Grace A, Pittaluga, Stefania, Ferré, Elise Mn, Usal, Claire, Anegon, Ignacio, Ranki, Annamari, Lionakis, Michail S, Peterson, Pärt, Guillonneau, Carole

“…Targeted monoclonal antibody (mAb) therapies show great promise for the treatment of transplant rejection and autoimmune diseases by inducing more specific…”
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Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function by Sampaio, Elizabeth P., Ding, Li, Rose, Stacey R., Cruz, Phillip, Hsu, Amy P., Kashyap, Anuj, Rosen, Lindsey B., Smelkinson, Margery, Tavella, Tatyana A., Ferre, Elise M.N., Wierman, Meredith K., Zerbe, Christa S., Lionakis, Michail S., Holland, Steven M.

“…Sumoylation is a posttranslational reversible modification of cellular proteins through the conjugation of small ubiquitin-related modifier (SUMO) and…”
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Successful Treatment of Paecilomyces variotii Pneumonia and Lupus Nephritis With Posaconazole-Cyclophosphamide Co-administration Without Drug Interaction–Induced Toxicity by Pechacek, Joseph, Webb, Taura, Ferré, Elise M N, Schmitt, Monica M, DiMaggio, Thomas, Kobrin, Dale, Rajasimhan, Suraj, Colton, Ben, Lewis, Russell E, Andes, David, Herrera, Alejandro, Hammoud, Dima, Seyedmousavi, Seyedmojtaba, Hasni, Sarfaraz, Bolaños, Jonathan, Afzali, Behdad, Lionakis, Michail S

“…Abstract Paecilomyces variotii is an opportunistic mold that causes pulmonary infections in immunosuppressed humans that are often treated with triazole…”
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Early recognition of the APECED rash can accelerate the diagnosis of APECED by Ferré, Elise M.N., Lee, Chyi-Chia R., Lionakis, Michail S.

“…•The APECED rash is a common, early manifestation of APECED syndrome.•The APECED rash is an urticarial eruption characterized histologically by…”
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Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes by Oftedal, Bergithe E., Assing, Kristian, Baris, Safa, Safgren, Stephanie L., Johansen, Isik S., Jakobsen, Marianne Antonius, Babovic-Vuksanovic, Dusica, Agre, Katherine, Klee, Eric W., Majcic, Emina, Ferré, Elise M.N., Schmitt, Monica M., DiMaggio, Tom, Rosen, Lindsey B., Rahman, Muhammad Obaidur, Chrysis, Dionisios, Giannakopoulos, Aristeidis, Garcia, Maria Tallon, González-Granado, Luis Ignacio, Stanley, Katherine, Galant-Swafford, Jessica, Suwannarat, Pim, Meyts, Isabelle, Lionakis, Michail S., Husebye, Eystein S.

“…Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity…”
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NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy–Like Disease by Zhu, Feng, Willette-Brown, Jami, Zhang, Jian, Ferre, Elise M.N., Sun, Zhonghe, Wu, Xiaolin, Lionakis, Michail S., Hu, Yinling

“…Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy show diverse endocrine and nonendocrine manifestations initiated by self-reactive…”
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Fatal autoimmune pneumonitis requiring bilobectomy and omental flap repair in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) by Kubala, Stephanie A., Do, Huy M., Ferré, Elise M.N., Schrump, David S., Olivier, Kenneth N., Walls, Jeffrey G., Lionakis, Michail S., Folio, Les R.

“…We present a severe case of progressive autoimmune pneumonitis requiring surgical intervention in a patient with the monogenic syndrome, autoimmune…”
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CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System by Drummond, Rebecca A, Collar, Amanda L, Swamydas, Muthulekha, Rodriguez, Carlos A, Lim, Jean K, Mendez, Laura M, Fink, Danielle L, Hsu, Amy P, Zhai, Bing, Karauzum, Hatice, Mikelis, Constantinos M, Rose, Stacey R, Ferre, Elise M N, Yockey, Lynne, Lemberg, Kimberly, Kuehn, Hye Sun, Rosenzweig, Sergio D, Lin, Xin, Chittiboina, Prashant, Datta, Sandip K, Belhorn, Thomas H, Weimer, Eric T, Hernandez, Michelle L, Hohl, Tobias M, Kuhns, Douglas B, Lionakis, Michail S

“…Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in the…”
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Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions by Martin-Fernandez, Marta, Bravo García-Morato, María, Gruber, Conor, Murias Loza, Sara, Malik, Muhammad Nasir Hayat, Alsohime, Fahad, Alakeel, Abdullah, Valdez, Rita, Buta, Sofija, Buda, Guadalupe, Marti, Marcelo A., Larralde, Margarita, Boisson, Bertrand, Feito Rodriguez, Marta, Qiu, Xueer, Chrabieh, Maya, Al Ayed, Mohammed, Al Muhsen, Saleh, Desai, Jigar V., Ferre, Elise M.N., Rosenzweig, Sergio D., Amador-Borrero, Blanca, Bravo-Gallego, Luz Yadira, Olmer, Ruth, Merkert, Sylvia, Bret, Montserrat, Sood, Amika K., Al-rabiaah, Abdulkarim, Temsah, Mohamad Hani, Halwani, Rabih, Hernandez, Michelle, Pessler, Frank, Casanova, Jean-Laurent, Bustamante, Jacinta, Lionakis, Michail S., Bogunovic, Dusan

“…Most monogenic disorders have a primary clinical presentation. Inherited ISG15 deficiency, however, has manifested with two distinct presentations to date:…”
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VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice by Break, Timothy J, Desai, Jigar V, Healey, Kelley R, Natarajan, Mukil, Ferre, Elise M N, Henderson, Christina, Zelazny, Adrian, Siebenlist, Ulrich, Yates, Christopher M, Cohen, Oren J, Schotzinger, Robert J, Perlin, David S, Garvey, Edward P, Lionakis, Michail S

“…Chronic mucocutaneous candidiasis (CMC) treatment often induces drug resistance, posing long-term challenges. A novel broad-spectrum fungal CYP51 inhibitor,…”
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Impact of periprocedural subcutaneous parathyroid hormone on control of hypocalcaemia in APS‐1/APECED patients undergoing invasive procedures by Winer, Karen K., Schmitt, Monica M., Ferre, Elise M. N., Fennelly, Kevin P., Olivier, Kenneth N., Heller, Theo, Lionakis, Michail S.

“…Context The monogenic disorder autoimmune polyendocrine syndrome type 1 (APS‐1) or autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy (APECED)…”
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AIRE expression controls the peripheral selection of autoreactive B cells by Sng, Joel, Ayoglu, Burcu, Chen, Jeff W, Schickel, Jean-Nicolas, Ferre, Elise M N, Glauzy, Salomé, Romberg, Neil, Hoenig, Manfred, Cunningham-Rundles, Charlotte, Utz, Paul J, Lionakis, Michail S, Meffre, Eric

“…Autoimmune regulator (AIRE) mutations result in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome characterized by defective…”
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VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans by Break, Timothy J, Desai, Jigar V, Natarajan, Mukil, Ferre, Elise M N, Henderson, Christina, Zelazny, Adrian M, Siebenlist, Ulrich, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P, Lionakis, Michail S

“…Candida albicans, the most common human fungal pathogen, causes chronic mucosal infections in patients with inborn errors of IL-17 immunity that rely heavily…”
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Autoantibody repertoire characterization provides insight into the pathogenesis of monogenic and polygenic autoimmune diseases by Clarke, Thomas, Du, Pan, Kumar, Satyendra, Okitsu, Shinji L, Schuette, Mark, An, Qi, Zhang, Jinyang, Tzvetkov, Evgeni, Jensen, Mark A, Niewold, Timothy B, Ferre, Elise M N, Nardone, Julie, Lionakis, Michail S, Vlach, Jaromir, DeMartino, Julie, Bender, Andrew T

“…Autoimmune diseases vary in the magnitude and diversity of autoantibody profiles, and these differences may be a consequence of different types of breaks in…”
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Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B by Pechacek, Joseph, Schmitt, Monica M, Ferrè, Elise M N, Webb, Taura, Goldberg, Joel, Pathan, Sabina, Banerjee, Camellia, Barber, Princess, DiMaggio, Thomas, Quinn, Anne, Matkovits, Theresa, Castelo-Soccio, Leslie, Nussenblatt, Veronique, Lionakis, Michail S

“…Abstract Prototheca wickerhamii is a rare cause of cutaneous and systemic infection that requires long treatment courses with potentially toxic medications. We…”
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Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes by Zimmerman, Ofer, Rosen, Lindsey B, Swamydas, Muthulekha, Ferre, Elise M N, Natarajan, Mukil, van de Veerdonk, Frank, Holland, Steven M, Lionakis, Michail S

“…Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by biallelic autoimmune…”
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Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' by Landegren, Nils, Rosen, Lindsey B, Freyhult, Eva, Eriksson, Daniel, Fall, Tove, Smith, Gustav, Ferre, Elise M N, Brodin, Petter, Sharon, Donald, Snyder, Michael, Lionakis, Michail, Anderson, Mark, Kämpe, Olle

“…The gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with…”
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The homozygous CX3CR1-M280 mutation impairs human monocyte survival by Collar, Amanda L, Swamydas, Muthulekha, O'Hayre, Morgan, Sajib, Md Sanaullah, Hoffman, Kevin W, Singh, Satya P, Mourad, Ahmad, Johnson, Melissa D, Ferre, Elise Mn, Farber, Joshua M, Lim, Jean K, Mikelis, Constantinos M, Gutkind, J Silvio, Lionakis, Michail S

“…Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a mouse model…”
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Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019 by Shaw, Elana R, Rosen, Lindsey B, Cheng, Aristine, Dobbs, Kerry, Delmonte, Ottavia M, Ferré, Elise M N, Schmitt, Monica M, Imberti, Luisa, Quaresima, Virginia, Lionakis, Michail S, Notarangelo, Luigi D, Holland, Steven M, Su, Helen C

“…Abstract Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly…”
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