Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors

Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors

The renin‐angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity‐associated metabolic effects. On t...

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Published in:Journal of cellular physiology Vol. 239; no. 6; pp. e31265 - n/a
Main Authors: Proença, Ana Beatriz, Medeiros, Gabriela Rodrigues, Reis, Guilherme dos Santos, Losito, Luiza da França, Ferraz, Luiza Mazzali, Bargut, Thereza Cristina Lonzetti, Soares, Nícia Pedreira, Alexandre‐Santos, Beatriz, Campagnole‐Santos, Maria Jose, Magliano, D'Angelo Carlo, Nobrega, Antonio Claudio Lucas da, Santos, Robson Augusto Souza, Frantz, Eliete Dalla Corte
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-06-2024
Subjects:
Adipogenesis
Adipose tissue
Adipose tissue (brown)
Adipose Tissue - metabolism
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Angiotensin AT1 receptors
Angiotensin receptors
Animals
beige adipocytes
Body fat
brown adipose tissue (BAT)
Endocrine system
Energy balance
Energy Metabolism
Homeostasis
Humans
Inflammation
Lipolysis
Mas receptor
Metabolism
MrgD receptor
Obesity
Obesity - metabolism
Obesity - pathology
Plastic foam
Plastic properties
Plasticity
Proto-Oncogene Mas
Receptors
Receptors, G-Protein-Coupled - metabolism
Renin
Renin-Angiotensin System - physiology
renin‐angiotensin system (RAS)
Signal Transduction
Thermogenesis
Thermogenesis - physiology
white adipose tissue (WAT)
renin‐angiotensin system (RAS)
Mas receptor
brown adipose tissue (BAT)
white adipose tissue (WAT)
MrgD receptor
beige adipocytes
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Summary:The renin‐angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity‐associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation of two receptors, the G protein‐coupled receptor (MasR) and Mas‐related receptor type D (MrgD). The local RAS in adipose organ has prompted extensive research into white adipose tissue and brown adipose tissue (BAT), with a key role in regulating the cellular and metabolic plasticity of these tissues. The MasR activation favors the brown plasticity signature in the adipose organ by improve the thermogenesis, adipogenesis, and lipolysis, decrease the inflammatory state, and overall energy homeostasis. The MrgD metabolic effects are related to the maintenance of BAT functionality, but the signaling remains unexplored. This review provides a summary of RAS counterregulatory actions triggered by Mas and MrgD receptors on adipose tissue plasticity. Focus on the effects related to the morphology and function of adipose tissue, especially from animal studies, will be given targeting new avenues for treatment of obesity‐associated metabolic effects.
Bibliography:Ana Beatriz Proença and Gabriela Rodrigues Medeiros contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0021-9541
1097-4652
1097-4652
DOI:10.1002/jcp.31265