Search Results - "Ferrara, Katherine"

Driving delivery vehicles with ultrasound by Ferrara, Katherine W.

“…Therapeutic applications of ultrasound have been considered for over 40 years, with the mild hyperthermia and associated increases in perfusion produced by…”
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Ultrasound localization microscopy to image and assess microvasculature in a rat kidney by Foiret, Josquin, Zhang, Hua, Ilovitsh, Tali, Mahakian, Lisa, Tam, Sarah, Ferrara, Katherine W.

“…The recent development of ultrasound localization microscopy, where individual microbubbles (contrast agents) are detected and tracked within the vasculature,…”
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Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment by Zhang, Nisi, Wang, James, Foiret, Josquin, Dai, Zhifei, Ferrara, Katherine W.

“…[Display omitted] Due to the ease of use and excellent safety profile, ultrasound is a promising technique for both diagnosis and site-specific therapy…”
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Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering by Qin, Shengping, Caskey, Charles F, Ferrara, Katherine W

“…Microbubble contrast agents and the associated imaging systems have developed over the past 25 years, originating with manually-agitated fluids introduced for…”
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Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery by Ferrara, Katherine, Pollard, Rachel, Borden, Mark

“…This review offers a critical analysis of the state of the art of medical microbubbles and their application in therapeutic delivery and monitoring. When…”
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Multiplexed ultrasound beam summation for side lobe reduction by Ilovitsh, Asaf, Ilovitsh, Tali, Ferrara, Katherine W.

“…Two-way focusing, which relies on sweeping a focused beam across a field of view, is the conventional method for performing high-quality ultrasound imaging…”
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Ultrasound Molecular Imaging of Tumor Angiogenesis With an Integrin Targeted Microbubble Contrast Agent by Anderson, Christopher R, Hu, Xiaowen, Zhang, Hua, Tlaxca, Jose, Declèves, Anne-Emilie, Houghtaling, Robert, Sharma, Kumar, Lawrence, Michael, Ferrara, Katherine W, Rychak, Joshua J

“…RATIONALE AND OBJECTIVES:Ultrasound molecular imaging is an emerging technique for sensitive detection of intravascular targets. Molecular imaging of…”
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Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE–/– Mice by Kheirolomoom, Azadeh, Kim, Chan Woo, Seo, Jai Woong, Kumar, Sandeep, Son, Dong Ju, Gagnon, M. Karen J, Ingham, Elizabeth S, Ferrara, Katherine W, Jo, Hanjoong

“…The current study presents an effective and selective multifunctional nanoparticle used to deliver antiatherogenic therapeutics to inflamed pro-atherogenic…”
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Improving plane wave ultrasound imaging through real-time beamformation across multiple arrays by Foiret, Josquin, Cai, Xiran, Bendjador, Hanna, Park, Eun-Yeong, Kamaya, Aya, Ferrara, Katherine W.

“…Ultrasound imaging is a widely used diagnostic tool but has limitations in the imaging of deep lesions or obese patients where the large depth to aperture size…”
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Nonviral ultrasound-mediated gene delivery in small and large animal models by Bez, Maxim, Foiret, Josquin, Shapiro, Galina, Pelled, Gadi, Ferrara, Katherine W., Gazit, Dan

“…Ultrasound-mediated gene delivery (sonoporation) is a minimally invasive, nonviral and clinically translatable method of gene therapy. This method offers a…”
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Spatial and Temporal Control of Hyperthermia Using Real Time Ultrasonic Thermal Strain Imaging with Motion Compensation, Phantom Study by Foiret, Josquin, Ferrara, Katherine W

“…Mild hyperthermia has been successfully employed to induce reversible physiological changes that can directly treat cancer and enhance local drug delivery. In…”
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Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging by Wang, Zhongling, Xue, Xiangdong, Lu, Hongwei, He, Yixuan, Lu, Ziwei, Chen, Zhijie, Yuan, Ye, Tang, Na, Dreyer, Courtney A., Quigley, Lizabeth, Curro, Nicholas, Lam, Kit S., Walton, Jeffrey H., Lin, Tzu-yin, Louie, Angelique Y., Gilbert, Dustin A., Liu, Kai, Ferrara, Katherine W., Li, Yuanpei

“…Distance-dependent magnetic resonance tuning (MRET) technology enables the sensing and quantitative imaging of biological targets in vivo, with the advantage…”
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Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis by Zhang, Guodong, Panigrahy, Dipak, Mahakian, Lisa M., Yang, Jun, Liu, Jun-Yan, Lee, Kin Sing Stephen, Wettersten, Hiromi I., Ulu, Arzu, Hu, Xiaowen, Tam, Sarah, Hwang, Sung Hee, Ingham, Elizabeth S., Kieran, Mark W., Weiss, Robert H., Ferrara, Katherine W., Hammock, Bruce D.

“…Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil) reduce the risks of macular degeneration and cancers, but the…”
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The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis by Son, Dong Ju, Kumar, Sandeep, Takabe, Wakako, Woo Kim, Chan, Ni, Chih-Wen, Alberts-Grill, Noah, Jang, In-Hwan, Kim, Sangok, Kim, Wankyu, Won Kang, Sang, Baker, Andrew H., Woong Seo, Jai, Ferrara, Katherine W., Jo, Hanjoong

“…MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is still unclear. Here we identify…”
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In situ T-cell transfection by anti-CD3-conjugated lipid nanoparticles leads to T-cell activation, migration, and phenotypic shift by Kheirolomoom, Azadeh, Kare, Aris J., Ingham, Elizabeth S., Paulmurugan, Ramasamy, Robinson, Elise R., Baikoghli, Mo, Inayathullah, Mohammed, Seo, Jai W., Wang, James, Fite, Brett Z., Wu, Bo, Tumbale, Spencer K., Raie, Marina N., Cheng, R. Holland, Nichols, Lisa, Borowsky, Alexander D., Ferrara, Katherine W.

“…Ex vivo programming of T cells can be efficacious but is complex and expensive; therefore, the development of methods to transfect T cells in situ is…”
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ω-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer by Wang, Weicang, Zhu, Julia, Lyu, Fei, Panigrahy, Dipak, Ferrara, Katherine W., Hammock, Bruce, Zhang, Guodong

“…Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to…”
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Sonogenetic control of multiplexed genome regulation and base editing by Liu, Pei, Foiret, Josquin, Situ, Yinglin, Zhang, Nisi, Kare, Aris J., Wu, Bo, Raie, Marina N., Ferrara, Katherine W., Qi, Lei S.

“…Manipulating gene expression in the host genome with high precision is crucial for controlling cellular function and behavior. Here, we present a precise,…”
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Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer by Fite, Brett Z., Wang, James, Kare, Aris J., Ilovitsh, Asaf, Chavez, Michael, Ilovitsh, Tali, Zhang, Nisi, Chen, Weiyu, Robinson, Elise, Zhang, Hua, Kheirolomoom, Azadeh, Silvestrini, Matthew T., Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah M., Davis, Ryan R., Tepper, Clifford G., Borowsky, Alexander D., Ferrara, Katherine W.

“…High intensity focused ultrasound (HIFU) rapidly and non-invasively destroys tumor tissue. Here, we sought to assess the immunomodulatory effects of MR-guided…”
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CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols by Seo, Jai Woong, Tavaré, Richard, Mahakian, Lisa M., Silvestrini, Matthew T., Tam, Sarah, Ingham, Elizabeth S., Salazar, Felix B., Borowsky, Alexander D., Wu, Anna M., Ferrara, Katherine W.

“…Abstract Purpose: Noninvasive and quantitative tracking of CD8+ T cells by PET has emerged as a potential technique to gauge response to immunotherapy. We…”
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Complete regression of local cancer using temperature-sensitive liposomes combined with ultrasound-mediated hyperthermia by Kheirolomoom, Azadeh, Lai, Chun-Yen, Tam, Sarah M., Mahakian, Lisa M., Ingham, Elizabeth S., Watson, Katherine D., Ferrara, Katherine W.

“…The development of treatment protocols that result in a complete response to chemotherapy has been hampered by free drug toxicity and the low bioavailability…”
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